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Items: 1 to 20 of 319

1.

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity.

Beom JY, Jung JA, Lee KT, Hwangbo A, Song MC, Lee Y, Lee SJ, Oh JH, Ha SJ, Nam SJ, Cheong E, Bahn YS, Yoon YJ.

J Nat Prod. 2019 Aug 23;82(8):2078-2086. doi: 10.1021/acs.jnatprod.9b00144. Epub 2019 Jul 19.

PMID:
31321978
2.

Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators.

Hassan AHE, Yoo SY, Lee KW, Yoon YM, Ryu HW, Jeong Y, Shin JS, Kang SY, Kim SY, Lee HH, Park BY, Lee KT, Lee YS.

Eur J Med Chem. 2019 Oct 15;180:253-267. doi: 10.1016/j.ejmech.2019.07.030. Epub 2019 Jul 9.

PMID:
31310917
3.

Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats.

Lee JY, Choi HY, Park CS, Jang C, Lee KT, Lee JY, Youn I, Yune TY.

Int Immunopharmacol. 2019 Oct;75:105738. doi: 10.1016/j.intimp.2019.105738. Epub 2019 Jul 12.

PMID:
31306980
4.

A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models.

Lee HH, Moon Y, Shin JS, Lee JH, Kim TW, Jang C, Park C, Lee J, Kim Y, Kim Y, Werz O, Park BY, Lee JY, Lee KT.

Prostaglandins Other Lipid Mediat. 2019 Jun 20;144:106347. doi: 10.1016/j.prostaglandins.2019.106347. [Epub ahead of print]

PMID:
31229523
5.

Caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one isolated from the leaves of Olinia usambarensis attenuates LPS-induced inflammatory mediators by inactivating AP-1 and NF-κB.

Kang SY, Shin JS, Kim SY, Noh YS, Lee SJ, Hwang H, Deyou T, Jang YP, Lee KT.

Chem Biol Interact. 2019 Aug 25;309:108718. doi: 10.1016/j.cbi.2019.06.031. Epub 2019 Jun 15.

PMID:
31211952
6.

A safety, pharmacokinetic, pharmacogenomic and population pharmacokinetic analysis of the third-generation EGFR TKI, olmutinib (HM61713), after single oral administration in healthy volunteers.

Noh YS, Yoon S, Kim SR, Lee KT, Jang IJ.

Basic Clin Pharmacol Toxicol. 2019 Oct;125(4):370-381. doi: 10.1111/bcpt.13262. Epub 2019 Jun 28.

PMID:
31125491
7.

Pharmacokinetic Analysis and Biomarker-Assisted Safety Assessment of Acetaminophen in Combination With Ojeok-san Compared With Acetaminophen Alone.

Park SI, Park JY, Lee JH, Park MS, Lee KT, Yim SV, Yoon YR, Kim BH.

J Clin Pharmacol. 2019 May 14. doi: 10.1002/jcph.1439. [Epub ahead of print]

PMID:
31090078
8.

Chemical Constituents from Leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblasts.

Shin JS, Han HS, Lee SB, Myung DB, Lee K, Lee SH, Kim HJ, Lee KT.

Biol Pharm Bull. 2019;42(3):424-431. doi: 10.1248/bpb.b18-00742.

9.

Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice.

Han HS, Shin JS, Myung DB, Ahn HS, Lee SH, Kim HJ, Lee KT.

Nutrients. 2019 Mar 1;11(3). pii: E533. doi: 10.3390/nu11030533.

10.

Pharmacokinetics and bioequivalence of two fenofibrate choline formulations in healthy subjects under fed and fasted condition
.

Park JM, Chae SI, Noh YS, Lee SJ, Shim WS, Yoon JM, Hwang SJ, Lee KT, Chung EK.

Int J Clin Pharmacol Ther. 2019 Apr;57(4):217-228. doi: 10.5414/CP203353.

PMID:
30802201
11.

Corrigendum to "Antiadipogenic Effects of Aster glehni Extract: In Vivo and In Vitro Effects".

Lee HM, Yang G, Ahn TG, Kim MD, Nugroho A, Park HJ, Lee KT, Park W, An HJ.

Evid Based Complement Alternat Med. 2019 Jan 10;2019:2459192. doi: 10.1155/2019/2459192. eCollection 2019.

12.

Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects.

Lee DH, Shin JS, Lee JS, Kang SY, Han HS, Ryu SM, Lee KT, Lee D, Jang DS.

Arch Pharm Res. 2019 Sep;42(9):766-772. doi: 10.1007/s12272-019-01117-0. Epub 2019 Feb 5.

PMID:
30721453
13.

Development and Validation of Simple LC-MS-MS Assay for the Quantitative Determination of Ticagrelor in Human Plasma: its Application to a Bioequivalence Study.

Chae SI, Yoo HJ, Lee SY, Chung EK, Shim WS, Lee KT.

J Chromatogr Sci. 2019 Apr 1;57(4):331-338. doi: 10.1093/chromsci/bmz001.

PMID:
30715279
14.

EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.

Elkamhawy A, Hassan AHE, Paik S, Sup Lee Y, Lee HH, Shin JS, Lee KT, Roh EJ.

Bioorg Chem. 2019 May;86:112-118. doi: 10.1016/j.bioorg.2019.01.017. Epub 2019 Jan 12.

PMID:
30685642
15.
16.

23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells.

Won JH, Chung KS, Park EY, Lee JH, Choi JH, Tapondjou LA, Park HJ, Nomura M, Hassan AHE, Lee KT.

Molecules. 2018 Dec 13;23(12). pii: E3306. doi: 10.3390/molecules23123306.

17.

Resveratrol analog, N-(4-methoxyphenyl)-3,5-dimethoxybenzamide induces G2/M phase cell cycle arrest and apoptosis in HeLa human cervical cancer cells.

Lee KW, Chung KS, Lee JH, Choi JH, Choi SY, Kim S, Lee JY, Lee KT.

Food Chem Toxicol. 2019 Feb;124:101-111. doi: 10.1016/j.fct.2018.11.062. Epub 2018 Nov 30.

PMID:
30508562
18.

Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects.

Kang WY, Seong SJ, Ohk B, Gwon MR, Kim BK, Cho S, Shim WS, Lee KT, Kim EH, Yang DH, Lee HW, Yoon YR.

Drug Des Devel Ther. 2018 Oct 26;12:3607-3615. doi: 10.2147/DDDT.S161917. eCollection 2018.

20.

Natural products hybrids: 3,5,4'-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells.

Hassan AHE, Choi E, Yoon YM, Lee KW, Yoo SY, Cho MC, Yang JS, Kim HI, Hong JY, Shin JS, Chung KS, Lee JH, Lee KT, Lee YS.

Eur J Med Chem. 2019 Jan 1;161:559-580. doi: 10.1016/j.ejmech.2018.10.062. Epub 2018 Oct 29.

PMID:
30396104

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