Helicity Modulation Improves the Selectivity of Antimicrobial Peptoids.
Nam HY, Choi J, Kumar SD, Nielsen JE, Kyeong M, Wang S, Kang D, Lee Y, Lee J, Yoon MH, Hong S, Lund R, Jenssen H, Shin SY, Seo J.
Nam HY, et al.
ACS Infect Dis. 2020 Oct 9;6(10):2732-2744. doi: 10.1021/acsinfecdis.0c00356. Epub 2020 Sep 15.
ACS Infect Dis. 2020.
PMID: 32865961
Among the moderately helical peptoids, the most dramatic increase in selectivity was observed in peptoid 17, providing more than a 20-fold increase compared to fully helical peptoid 1. Peptoid 17 had potent broad-spectrum antimicrobial activity that included clinically iso …
Among the moderately helical peptoids, the most dramatic increase in selectivity was observed in peptoid 17, providing more than a 20 …