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Items: 1 to 20 of 52

1.

Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.

Simón Serrano S, Grönberg A, Longato L, Rombouts K, Kuo J, Gregory M, Moss S, Elmér E, Mazza G, Gallay P, Pinzani M, Hansson MJ, Massoumi R.

Cells. 2019 Nov 8;8(11). pii: E1409. doi: 10.3390/cells8111409.

2.

Clinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasms.

Laskaratos FM, Mandair D, Hall A, Alexander S, von Stempel C, Bretherton J, Luong T, Watkins J, Ogunbiyi O, Rombouts K, Caplin M, Toumpanakis C.

Endocrine. 2019 Oct 9. doi: 10.1007/s12020-019-02107-4. [Epub ahead of print]

PMID:
31598848
3.

Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.

De Chiara F, Thomsen KL, Habtesion A, Jones H, Davies N, Gracia-Sancho J, Manicardi N, Hall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, Mookerjee RP, Mann J, Jalan R.

Hepatology. 2019 Aug 5. doi: 10.1002/hep.30890. [Epub ahead of print]

PMID:
31378982
4.

Decellularized Human Gut as a Natural 3D Platform for Research in Intestinal Fibrosis.

Giuffrida P, Curti M, Al-Akkad W, Biel C, Crowley C, Frenguelli L, Telese A, Hall A, Tamburrino D, Spoletini G, Fusai G, Tinozzi FP, Pietrabissa A, Corazza GR, De Coppi P, Pinzani M, Di Sabatino A, Rombouts K, Mazza G.

Inflamm Bowel Dis. 2019 Oct 18;25(11):1740-1750. doi: 10.1093/ibd/izz115.

PMID:
31199863
5.

Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis.

Lachowski D, Cortes E, Rice A, Pinato D, Rombouts K, Del Rio Hernandez A.

Sci Rep. 2019 May 13;9(1):7299. doi: 10.1038/s41598-019-43759-6.

6.

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells.

Gentilini A, Caligiuri A, Raggi C, Rombouts K, Pinzani M, Lori G, Correnti M, Invernizzi P, Rovida E, Navari N, Di Matteo S, Alvaro D, Banales JM, Rodrigues P, Raschioni C, Donadon M, Di Tommaso L, Marra F.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2246-2256. doi: 10.1016/j.bbadis.2019.04.020. Epub 2019 May 3.

PMID:
31059778
7.

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.

Becares N, Gage MC, Voisin M, Shrestha E, Martin-Gutierrez L, Liang N, Louie R, Pourcet B, Pello OM, Luong TV, Goñi S, Pichardo-Almarza C, Røberg-Larsen H, Diaz-Zuccarini V, Steffensen KR, O'Brien A, Garabedian MJ, Rombouts K, Treuter E, Pineda-Torra I.

Cell Rep. 2019 Jan 22;26(4):984-995.e6. doi: 10.1016/j.celrep.2018.12.094.

8.

Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.

Cortes E, Lachowski D, Rice A, Thorpe SD, Robinson B, Yeldag G, Lee DA, Ghemtio L, Rombouts K, Del Río Hernández AE.

Oncogene. 2019 Apr;38(16):2910-2922. doi: 10.1038/s41388-018-0631-3. Epub 2018 Dec 21.

9.

Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma.

Bárcena-Varela M, Caruso S, Llerena S, Álvarez-Sola G, Uriarte I, Latasa MU, Urtasun R, Rebouissou S, Alvarez L, Jimenez M, Santamaría E, Rodriguez-Ortigosa C, Mazza G, Rombouts K, San José-Eneriz E, Rabal O, Agirre X, Iraburu M, Santos-Laso A, Banales JM, Zucman-Rossi J, Prósper F, Oyarzabal J, Berasain C, Ávila MA, Fernández-Barrena MG.

Hepatology. 2019 Feb;69(2):587-603. doi: 10.1002/hep.30168. Epub 2019 Jan 4.

PMID:
30014490
10.

Urea cycle dysregulation in non-alcoholic fatty liver disease.

De Chiara F, Heebøll S, Marrone G, Montoliu C, Hamilton-Dutoit S, Ferrandez A, Andreola F, Rombouts K, Grønbæk H, Felipo V, Gracia-Sancho J, Mookerjee RP, Vilstrup H, Jalan R, Thomsen KL.

J Hepatol. 2018 Oct;69(4):905-915. doi: 10.1016/j.jhep.2018.06.023. Epub 2018 Jul 5.

PMID:
29981428
11.

The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells.

Marrone G, De Chiara F, Böttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang Z, Marrali M, Fernández-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K.

Hepatology. 2018 Sep;68(3):1140-1153. doi: 10.1002/hep.30029. Epub 2018 Jul 16.

PMID:
29663481
12.

Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis.

Thomsen KL, De Chiara F, Rombouts K, Vilstrup H, Andreola F, Mookerjee RP, Jalan R.

Med Hypotheses. 2018 Apr;113:91-97. doi: 10.1016/j.mehy.2018.02.010. Epub 2018 Feb 15.

PMID:
29523305
13.

Liver tissue engineering: From implantable tissue to whole organ engineering.

Mazza G, Al-Akkad W, Rombouts K, Pinzani M.

Hepatol Commun. 2017 Dec 21;2(2):131-141. doi: 10.1002/hep4.1136. eCollection 2018 Feb. Review.

14.

MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation.

Böttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong T, Tsochatzis EA, Thorburn D, Pinzani M.

Hepatology. 2018 Jul;68(1):172-186. doi: 10.1002/hep.29782. Epub 2018 May 9.

PMID:
29328499
15.

Neuroendocrine tumors and fibrosis: An unsolved mystery?

Laskaratos FM, Rombouts K, Caplin M, Toumpanakis C, Thirlwell C, Mandair D.

Cancer. 2017 Dec 15;123(24):4770-4790. doi: 10.1002/cncr.31079. Epub 2017 Nov 7. Review.

16.

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.

Lachowski D, Cortes E, Robinson B, Rice A, Rombouts K, Del Río Hernández AE.

FASEB J. 2018 Feb;32(2):1099-1107. doi: 10.1096/fj.201700721R. Epub 2018 Jan 3.

PMID:
29070586
17.

Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.

Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N.

J Biol Chem. 2017 Nov 17;292(46):18961-18972. doi: 10.1074/jbc.M117.793794. Epub 2017 Sep 15.

18.

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Hirschfield GM, Hoek BV, Holm K, Hohenester S, Hov JR, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vila AV, Vries B, Zachou K; International PSC Study Group, The UK PSC Consortium, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK.

Gut. 2018 Aug;67(8):1517-1524. doi: 10.1136/gutjnl-2016-313598. Epub 2017 Aug 4.

19.

TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.

Singh HD, Otano I, Rombouts K, Singh KP, Peppa D, Gill US, Böttcher K, Kennedy PTF, Oben J, Pinzani M, Walczak H, Fusai G, Rosenberg WMC, Maini MK.

Sci Rep. 2017 Jul 17;7(1):5514. doi: 10.1038/s41598-017-05845-5.

20.

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization.

Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, Hall A, Kong K, Frenguelli L, Marrone G, Willacy O, Shaeri M, Burns A, Malago M, Gilbertson J, Rendell N, Moore K, Hughes D, Notingher I, Jell G, Del Rio Hernandez A, De Coppi P, Rombouts K, Pinzani M.

Sci Rep. 2017 Jul 17;7(1):5534. doi: 10.1038/s41598-017-05134-1.

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