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World J Gastroenterol. 2006 Feb 7;12(5):791-5.

Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer.

Author information

1
Hepatogastroenterology Unit, 2nd Department of Internal Medicine, Attikon University General Hospital, 23 Sisini Street, 11528 Athens, Greece.

Abstract

AIM:

To evaluate the omeprazole maintenance therapy in patients with recurrent ulcer bleeding after surgery for duodenal ulcer.

METHODS:

We studied 15 consecutive patients with recurrent ulcer bleeding after surgery for duodenal ulcer. Omeprazole (20 mg/d) maintenance therapy was given after ulcer healing. In addition to clinical follow-up, ambulatory 24-h gastric pH assay was performed before and during omeprazole therapy in those patients and controls with previous duodenal ulcer surgery but no ulcer recurrence.

RESULTS:

All the 15 ulcers were healed after being treated with omeprazole (40 mg/d) for 2 mo. Eleven patients with two (1-9) episodes of recurrent ulcer bleeding completed the follow-up (43, 12-72 mo). None of them had a bleeding episode while on omeprazole. One patient discontinued the therapy and had recurrent bleeding. The median 24-h fraction time of gastric pH<4 in patients was 80, 46-95%, and was reduced to 32, 13-70% by omeprazole (P=0.002).

CONCLUSION:

Long-term maintenance therapy with omeprazole (20 mg/day) is effective in preventing recurrent ulcer bleeding.

PMID:
16521197
PMCID:
PMC4066134
DOI:
10.3748/wjg.v12.i5.791
[Indexed for MEDLINE]
Free PMC Article

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