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Items: 1 to 20 of 122

1.

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Sen NE, Arsovic A, Meierhofer D, Brodesser S, Oberschmidt C, Canet-Pons J, Kaya ZE, Halbach MV, Gispert S, Sandhoff K, Auburger G.

Int J Mol Sci. 2019 Nov 21;20(23). pii: E5854. doi: 10.3390/ijms20235854.

2.

Emerging mechanisms of drug-induced phospholipidosis.

Breiden B, Sandhoff K.

Biol Chem. 2019 Dec 18;401(1):31-46. doi: 10.1515/hsz-2019-0270. Review.

PMID:
31408430
3.

Lysosomal Glycosphingolipid Storage Diseases.

Breiden B, Sandhoff K.

Annu Rev Biochem. 2019 Jun 20;88:461-485. doi: 10.1146/annurev-biochem-013118-111518.

PMID:
31220974
4.

Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs.

Anheuser S, Breiden B, Sandhoff K.

Mol Genet Metab. 2019 Sep - Oct;128(1-2):75-83. doi: 10.1016/j.ymgme.2019.04.007. Epub 2019 May 4.

PMID:
31097363
5.

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles.

Anheuser S, Breiden B, Sandhoff K.

J Lipid Res. 2019 Jun;60(6):1099-1111. doi: 10.1194/jlr.M092551. Epub 2019 Apr 15.

PMID:
30988135
6.

Ganglioside Metabolism and Its Inherited Diseases.

Breiden B, Sandhoff K.

Methods Mol Biol. 2018;1804:97-141. doi: 10.1007/978-1-4939-8552-4_5. Review.

PMID:
29926406
7.

Emerging concepts of ganglioside metabolism.

Sandhoff R, Sandhoff K.

FEBS Lett. 2018 Dec;592(23):3835-3864. doi: 10.1002/1873-3468.13114. Epub 2018 Jun 16. Review.

8.

Ganglioside Metabolism in Health and Disease.

Sandhoff R, Schulze H, Sandhoff K.

Prog Mol Biol Transl Sci. 2018;156:1-62. doi: 10.1016/bs.pmbts.2018.01.002. Epub 2018 Mar 28. Review.

PMID:
29747811
9.

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.

Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze JL, Dörmann P, Hartmann D, Bauer R, Willecke K.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):734-749. doi: 10.1016/j.bbalip.2018.04.006. Epub 2018 Apr 10.

PMID:
29653252
10.

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements.

Sociale M, Wulf AL, Breiden B, Klee K, Thielisch M, Eckardt F, Sellin J, Bülow MH, Löbbert S, Weinstock N, Voelzmann A, Schultze J, Sandhoff K, Bauer R.

Cell Rep. 2018 Jan 23;22(4):967-978. doi: 10.1016/j.celrep.2017.12.090. Epub 2018 Jan 28.

11.

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants.

Bülow MH, Wingen C, Senyilmaz D, Gosejacob D, Sociale M, Bauer R, Schulze H, Sandhoff K, Teleman AA, Hoch M, Sellin J.

Mol Biol Cell. 2018 Feb 15;29(4):396-407. doi: 10.1091/mbc.E17-08-0535. Epub 2017 Dec 27.

12.

Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases.

Sellin J, Schulze H, Paradis M, Gosejacob D, Papan C, Shevchenko A, Psathaki OE, Paululat A, Thielisch M, Sandhoff K, Hoch M.

Dis Model Mech. 2017 Jun 1;10(6):737-750. doi: 10.1242/dmm.027953. Epub 2017 Apr 7.

13.

Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D.

Graf CGF, Schulz C, Schmälzlein M, Heinlein C, Mönnich M, Perkams L, Püttner M, Boos I, Hessefort M, Lombana Sanchez JN, Weyand M, Steegborn C, Breiden B, Ross K, Schwarzmann G, Sandhoff K, Unverzagt C.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5252-5257. doi: 10.1002/anie.201701362. Epub 2017 Apr 5.

PMID:
28378443
14.

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.

Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D.

J Biol Chem. 2017 Apr 14;292(15):6177-6189. doi: 10.1074/jbc.M116.762831. Epub 2017 Mar 3.

15.

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.

Abdul-Hammed M, Breiden B, Schwarzmann G, Sandhoff K.

J Lipid Res. 2017 Mar;58(3):563-577. doi: 10.1194/jlr.M073510. Epub 2017 Jan 26.

16.

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism.

Sandhoff K.

Biochimie. 2016 Nov;130:146-151. doi: 10.1016/j.biochi.2016.05.004. Epub 2016 May 5. Review.

PMID:
27157270
17.

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer.

Schwarzmann G, Breiden B, Sandhoff K.

J Lipid Res. 2015 Oct;56(10):1861-79. doi: 10.1194/jlr.M056929. Epub 2015 Aug 11.

18.

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

Anheuser S, Breiden B, Schwarzmann G, Sandhoff K.

J Lipid Res. 2015 Sep;56(9):1747-61. doi: 10.1194/jlr.M061036. Epub 2015 Jul 14.

19.

Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics.

Raju D, Schonauer S, Hamzeh H, Flynn KC, Bradke F, Vom Dorp K, Dörmann P, Yildiz Y, Trötschel C, Poetsch A, Breiden B, Sandhoff K, Körschen HG, Wachten D.

PLoS Genet. 2015 Mar 24;11(3):e1005063. doi: 10.1371/journal.pgen.1005063. eCollection 2015 Mar.

20.

Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification.

Gantner M, Schwarzmann G, Sandhoff K, Kolter T.

J Lipid Res. 2014 Dec;55(12):2692-704. doi: 10.1194/jlr.D054734. Epub 2014 Oct 22.

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