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Items: 1 to 20 of 35

1.

Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.

Zhu K, Shao J, Tao H, Yan X, Luo C, Zhang H, Duan W.

J Comput Aided Mol Des. 2019 Jul 16. doi: 10.1007/s10822-019-00214-y. [Epub ahead of print]

PMID:
31312965
2.

Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation.

Jiang CS, Ge YX, Cheng ZQ, Wang YY, Tao HR, Zhu K, Zhang H.

Molecules. 2019 Jul 15;24(14). pii: E2568. doi: 10.3390/molecules24142568.

PMID:
31311169
3.

Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities.

Yang F, Zhao N, Song J, Zhu K, Jiang CS, Shan P, Zhang H.

Molecules. 2019 Jul 15;24(14). pii: E2569. doi: 10.3390/molecules24142569.

PMID:
31311163
4.

Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α.

Zheng BN, Ding CH, Chen SJ, Zhu K, Shao J, Feng J, Xu WP, Cai LY, Zhu CP, Duan W, Ding J, Zhang X, Luo C, Xie WF.

Theranostics. 2019 Apr 13;9(9):2606-2617. doi: 10.7150/thno.32344. eCollection 2019.

5.

Secondary metabolites from the mangrove sediment-derived fungus Penicillium pinophilum SCAU037.

He F, Li X, Yu JH, Zhang X, Nong X, Chen G, Zhu K, Wang YY, Bao J, Zhang H.

Fitoterapia. 2019 Jul;136:104177. doi: 10.1016/j.fitote.2019.104177. Epub 2019 May 22.

PMID:
31128244
6.

Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation.

Jiang CS, Ge YX, Cheng ZQ, Song JL, Wang YY, Zhu K, Zhang H.

J Comput Aided Mol Des. 2019 May;33(5):521-530. doi: 10.1007/s10822-019-00202-2. Epub 2019 Apr 15.

PMID:
30989573
7.

Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations.

Tao H, Yan X, Zhu K, Zhang H.

Chem Pharm Bull (Tokyo). 2019;67(4):382-388. doi: 10.1248/cpb.c18-00980.

8.

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

Shao J, Zhu K, Du D, Zhang Y, Tao H, Chen Z, Jiang H, Chen K, Luo C, Duan W.

Eur J Med Chem. 2019 Feb 15;164:317-333. doi: 10.1016/j.ejmech.2018.12.065. Epub 2018 Dec 26.

PMID:
30605830
9.

Development of hydroxamate-based histone deacetylase inhibitors containing 1,2,4-oxadiazole moiety core with antitumor activities.

Yang F, Shan P, Zhao N, Ge D, Zhu K, Jiang CS, Li P, Zhang H.

Bioorg Med Chem Lett. 2019 Jan 1;29(1):15-21. doi: 10.1016/j.bmcl.2018.11.027. Epub 2018 Nov 14.

PMID:
30455152
10.

Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors.

Zhu K, Song JL, Tao HR, Cheng ZQ, Jiang CS, Zhang H.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3693-3699. doi: 10.1016/j.bmcl.2018.10.026. Epub 2018 Oct 19.

PMID:
30366617
11.

Total synthesis, structural revision and biological evaluation of γ-elemene-type sesquiterpenes.

Yuan C, Zhong S, Li X, Wang Y, Xun MM, Bai Y, Zhu K.

Org Biomol Chem. 2018 Oct 31;16(42):7843-7850. doi: 10.1039/c8ob02005a.

PMID:
30303229
12.

Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer.

Mao J, Ma L, Shen Y, Zhu K, Zhang R, Xi W, Ruan Z, Luo C, Chen Z, Xi X, Chen S.

Cell Death Dis. 2018 Sep 20;9(10):963. doi: 10.1038/s41419-018-0998-7.

13.

Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations.

Zhu K, Tao H, Song JL, Jin L, Zhang Y, Liu J, Chen Z, Jiang CS, Luo C, Zhang H.

Bioorg Chem. 2018 Dec;81:289-298. doi: 10.1016/j.bioorg.2018.08.021. Epub 2018 Aug 20.

PMID:
30172110
14.
15.

Current Strategies and Applications for Precision Drug Design.

Wang C, Xu P, Zhang L, Huang J, Zhu K, Luo C.

Front Pharmacol. 2018 Jul 18;9:787. doi: 10.3389/fphar.2018.00787. eCollection 2018. Review.

16.

New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa.

Song XQ, Zhu K, Yu JH, Zhang Q, Zhang Y, He F, Cheng ZQ, Jiang CS, Bao J, Zhang H.

Molecules. 2018 Jul 14;23(7). pii: E1723. doi: 10.3390/molecules23071723.

17.

Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008.

Bao J, Zhai H, Zhu K, Yu JH, Zhang Y, Wang Y, Jiang CS, Zhang X, Zhang Y, Zhang H.

Mar Drugs. 2018 May 22;16(5). pii: E174. doi: 10.3390/md16050174.

18.

Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy.

Jiang CS, Zhuang CL, Zhu K, Zhang J, Muehlmann LA, Figueiró Longo JP, Azevedo RB, Zhang W, Meng N, Zhang H.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):833-841. doi: 10.1080/14756366.2018.1461856.

19.

Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.

Zhu K, Jiang C, Tao H, Liu J, Zhang H, Luo C.

Bioorg Med Chem Lett. 2018 May 15;28(9):1476-1483. doi: 10.1016/j.bmcl.2018.03.087. Epub 2018 Mar 30.

PMID:
29628326
20.

Phenolic bisabolane sesquiterpenoids from a Thai mangrove endophytic fungus, Aspergillus sp. xy02.

Wang P, Yu JH, Zhu K, Wang Y, Cheng ZQ, Jiang CS, Dai JG, Wu J, Zhang H.

Fitoterapia. 2018 Jun;127:322-327. doi: 10.1016/j.fitote.2018.02.031. Epub 2018 Mar 12.

PMID:
29544761

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