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Items: 1 to 20 of 202


Engineering Photorhabdus luminescens toxin complex (PTC) into a recombinant injection nanomachine.

Ng Ang A PN, Ebner JK, Plessner M, Aktories K, Schmidt G.

Life Sci Alliance. 2019 Sep 20;2(5). pii: e201900485. doi: 10.26508/lsa.201900485. Print 2019 Oct.


Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva.

Ebner JK, König GM, Kostenis E, Siegert P, Aktories K, Orth JHC.

Bone. 2019 Oct;127:592-601. doi: 10.1016/j.bone.2019.07.031. Epub 2019 Jul 31.


cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs.

Aktories K, Gierschik P, Heringdorf DMZ, Schmidt M, Schultz G, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392(8):887-911. doi: 10.1007/s00210-019-01650-1. Epub 2019 May 17. Review.


Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H.

FASEB J. 2019 Apr;33(4):5755-5771. doi: 10.1096/fj.201802453R. Epub 2019 Jan 30.


Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K.

FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28.


The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase.

Levanova N, Mattheis C, Carson D, To KN, Jank T, Frankel G, Aktories K, Schroeder GN.

J Biol Chem. 2019 Feb 22;294(8):2862-2879. doi: 10.1074/jbc.RA118.005952. Epub 2018 Dec 20.


A cysteine protease-like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox.

Bogdanovic X, Schneider S, Levanova N, Wirth C, Trillhaase C, Steinemann M, Hunte C, Aktories K, Jank T.

J Biol Chem. 2019 Jan 18;294(3):1035-1044. doi: 10.1074/jbc.RA118.005043. Epub 2018 Nov 26.


Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells.

Ost GS, Ng'ang'a PN, Lang AE, Aktories K.

Cell Microbiol. 2019 Mar;21(3):e12978. doi: 10.1111/cmi.12978. Epub 2018 Dec 2.


Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA.

Levanova N, Steinemann M, Böhmer KE, Schneider S, Belyi Y, Schlosser A, Aktories K, Jank T.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Jan;392(1):69-79. doi: 10.1007/s00210-018-1562-9. Epub 2018 Sep 17.


The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B.

Steinemann M, Schlosser A, Jank T, Aktories K.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585. doi: 10.1073/pnas.1807658115. Epub 2018 Sep 4.


Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin.

Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C.

Nat Commun. 2018 Aug 30;9(1):3524. doi: 10.1038/s41467-018-05850-w.


Involvement of Osteocytes in the Action of Pasteurella multocida Toxin.

Heni H, Ebner JK, Schmidt G, Aktories K, Orth JHC.

Toxins (Basel). 2018 Aug 13;10(8). pii: E328. doi: 10.3390/toxins10080328.


Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.

Brink T, Leiss V, Siegert P, Jehle D, Ebner JK, Schwan C, Shymanets A, Wiese S, Nürnberg B, Hensel M, Aktories K, Orth JHC.

PLoS Pathog. 2018 Aug 13;14(8):e1007248. doi: 10.1371/journal.ppat.1007248. eCollection 2018 Aug.


Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL.

Schorch B, Heni H, Zahaf NI, Brummer T, Mione M, Schmidt G, Papatheodorou P, Aktories K.

Oncotarget. 2018 Mar 27;9(23):16489-16500. doi: 10.18632/oncotarget.24740. eCollection 2018 Mar 27.


Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton.

Aktories K, Papatheodorou P, Schwan C.

Anaerobe. 2018 Oct;53:21-29. doi: 10.1016/j.anaerobe.2018.03.001. Epub 2018 Mar 7. Review.


Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins.

Papatheodorou P, Barth H, Minton N, Aktories K.

Adv Exp Med Biol. 2018;1050:77-96. doi: 10.1007/978-3-319-72799-8_6. Review.


Specific role of RhoC in tumor invasion and metastasis.

Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G.

Oncotarget. 2017 Sep 16;8(50):87364-87378. doi: 10.18632/oncotarget.20957. eCollection 2017 Oct 20.


Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells.

Østevold K, Meléndez AV, Lehmann F, Schmidt G, Aktories K, Schwan C.

Oncotarget. 2017 Sep 11;8(44):76686-76698. doi: 10.18632/oncotarget.20805. eCollection 2017 Sep 29.


Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.

Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K.

J Biol Chem. 2017 Sep 29;292(39):16014-16023. doi: 10.1074/jbc.M117.801035. Epub 2017 Aug 11.


Clostridium difficile Toxin Biology.

Aktories K, Schwan C, Jank T.

Annu Rev Microbiol. 2017 Sep 8;71:281-307. doi: 10.1146/annurev-micro-090816-093458. Epub 2017 Jun 28. Review.


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