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Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer.

Jeusset LM, McManus KJ.

Cells. 2019 Feb 16;8(2). pii: E165. doi: 10.3390/cells8020165. Review.


Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity.

Lepage CC, Morden CR, Palmer MCL, Nachtigal MW, McManus KJ.

Cancers (Basel). 2019 Feb 15;11(2). pii: E226. doi: 10.3390/cancers11020226. Review.


Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers.

Cisyk AL, Nugent Z, Wightman RH, Singh H, McManus KJ.

Neoplasia. 2018 Sep;20(9):943-950. doi: 10.1016/j.neo.2018.07.007. Epub 2018 Aug 15.


Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer.

Jeusset LM, McManus KJ.

Cancers (Basel). 2017 Dec 6;9(12). pii: E167. doi: 10.3390/cancers9120167. Review.


Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer.

Thompson LL, Jeusset LM, Lepage CC, McManus KJ.

Cancers (Basel). 2017 Nov 1;9(11). pii: E151. doi: 10.3390/cancers9110151. Review.


KIF11 silencing and inhibition induces chromosome instability that may contribute to cancer.

Asbaghi Y, Thompson LL, Lichtensztejn Z, McManus KJ.

Genes Chromosomes Cancer. 2017 Sep;56(9):668-680. doi: 10.1002/gcc.22471. Epub 2017 Jun 15.


Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition.

Guppy BJ, McManus KJ.

Cell Oncol (Dordr). 2017 Jun;40(3):281-292. doi: 10.1007/s13402-017-0323-y. Epub 2017 May 1.


The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples.

Penner-Goeke S, Lichtensztejn Z, Neufeld M, Ali JL, Altman AD, Nachtigal MW, McManus KJ.

PLoS Genet. 2017 Apr 4;13(4):e1006707. doi: 10.1371/journal.pgen.1006707. eCollection 2017 Apr.


The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer.

McAndrew EN, McManus KJ.

Genes Chromosomes Cancer. 2017 Jul;56(7):513-523. doi: 10.1002/gcc.22458. Epub 2017 Apr 4. Review.


The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition.

McAndrew EN, Lepage CC, McManus KJ.

Oncotarget. 2016 Dec 27;7(52):87417-87430. doi: 10.18632/oncotarget.13654.


Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells.

Sajesh BV, McManus KJ.

Oncotarget. 2015 Sep 29;6(29):27907-22. doi: 10.18632/oncotarget.4875.


A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells.

Thompson LL, McManus KJ.

PLoS One. 2015 Apr 20;10(4):e0123200. doi: 10.1371/journal.pone.0123200. eCollection 2015.


Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells.

Guppy BJ, McManus KJ.

Genetics. 2015 Feb;199(2):423-33. doi: 10.1534/genetics.114.172874. Epub 2014 Dec 22.


Establishing a biological profile for interval colorectal cancers.

Cisyk AL, Singh H, McManus KJ.

Dig Dis Sci. 2014 Oct;59(10):2390-402. doi: 10.1007/s10620-014-3210-7. Epub 2014 May 20. Review.


Synthetic genetic targeting of genome instability in cancer.

Sajesh BV, Guppy BJ, McManus KJ.

Cancers (Basel). 2013 Jun 24;5(3):739-61. doi: 10.3390/cancers5030739.


Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.

Sajesh BV, Bailey M, Lichtensztejn Z, Hieter P, McManus KJ.

Genetics. 2013 Nov;195(3):757-67. doi: 10.1534/genetics.113.156836. Epub 2013 Sep 3.


Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells.

Sajesh BV, Lichtensztejn Z, McManus KJ.

BMC Cancer. 2013 Aug 20;13:391. doi: 10.1186/1471-2407-13-391.


Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.

Price JC, Pollock LM, Rudd ML, Fogoros SK, Mohamed H, Hanigan CL, Le Gallo M; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Zhang S, Cruz P, Cherukuri PF, Hansen NF, McManus KJ, Godwin AK, Sgroi DC, Mullikin JC, Merino MJ, Hieter P, Bell DW.

PLoS One. 2013 Jun 3;8(6):e63313. doi: 10.1371/journal.pone.0063313. Print 2014.


Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis.

Thompson LL, Guppy BJ, Sawchuk L, Davie JR, McManus KJ.

Cancer Metastasis Rev. 2013 Dec;32(3-4):363-76. doi: 10.1007/s10555-013-9434-8. Review.


An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.

van Pel DM, Barrett IJ, Shimizu Y, Sajesh BV, Guppy BJ, Pfeifer T, McManus KJ, Hieter P.

PLoS Genet. 2013;9(1):e1003254. doi: 10.1371/journal.pgen.1003254. Epub 2013 Jan 31. Erratum in: PLoS Genet. 2013 Feb;9(2). doi: 10.1371/annotation/a26cb527-ec18-46ec-a63f-c69d0983add6.

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