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Bioengineering (Basel). 2019 Apr 30;6(2). pii: E38. doi: 10.3390/bioengineering6020038.

Bioengineering an Artificial Human Blood⁻Brain Barrier in Rodents.

Author information

1
Department of Neurological Surgery, UC Davis Medical Center, Sacramento, CA 95811, USA. kkamal@ucdavis.edu.
2
Department of Neurological Surgery, UC Davis Medical Center, Sacramento, CA 95811, USA. bwaldau@ucdavis.edu.

Abstract

Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling.

KEYWORDS:

NSG mouse; blood–brain barrier; cerebrovascular disease; immune system; organoid; perfusion; vascularization

PMID:
31052208
DOI:
10.3390/bioengineering6020038
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