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ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort.

Sabherwal S, Föcking M, English JA, Fitzsimons S, Hryniewiecka M, Wynne K, Scaife C, Healy C, Cannon M, Belton O, Zammit S, Cagney G, Cotter DR.

Schizophr Res. 2019 Jul;209:141-147. doi: 10.1016/j.schres.2019.05.002. Epub 2019 May 10.


SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

Alsulami M, Munawar N, Dillon E, Oliviero G, Wynne K, Alsolami M, Moss C, Ó Gaora P, O'Meara F, Cotter D, Cagney G.

Mol Cell Proteomics. 2019 Jul;18(7):1428-1436. doi: 10.1074/mcp.RA119.001518. Epub 2019 May 10.


Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J.

FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR. Epub 2019 Feb 19.


Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress.

Föcking M, Sabherwal S, Cates HM, Scaife C, Dicker P, Hryniewiecka M, Wynne K, Rutten BPF, Lewis G, Cannon M, Nestler EJ, Heurich M, Cagney G, Zammit S, Cotter DR.

Mol Psychiatry. 2019 Jan 11. doi: 10.1038/s41380-018-0306-z. [Epub ahead of print]


Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.

Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA.

Elife. 2018 Nov 15;7. pii: e41305. doi: 10.7554/eLife.41305.


The Platelet Releasate is Altered in Human Pregnancy.

Szklanna PB, Parsons ME, Wynne K, O'Connor H, Egan K, Allen S, Ní Áinle F, Maguire PB.

Proteomics Clin Appl. 2019 May;13(3):e1800162. doi: 10.1002/prca.201800162. Epub 2018 Oct 29.


PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.

Rodriguez J, Herrero A, Li S, Rauch N, Quintanilla A, Wynne K, Krstic A, Acosta JC, Taylor C, Schlisio S, von Kriegsheim A.

Cell Rep. 2018 Jul 31;24(5):1316-1329. doi: 10.1016/j.celrep.2018.06.108.


Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.

Parsons MEM, Szklanna PB, Guerrero JA, Wynne K, Dervin F, O'Connell K, Allen S, Egan K, Bennett C, McGuigan C, Gheveart C, Ní Áinle F, Maguire PB.

Proteomics. 2018 Aug;18(15):e1800219. doi: 10.1002/pmic.201800219. Epub 2018 Jul 15.


A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.

Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP.

Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5.


The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.

Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G.

Mol Cell. 2018 Apr 19;70(2):371-379.e5. doi: 10.1016/j.molcel.2018.02.027. Epub 2018 Mar 29.


Proteomic Analysis Reveals a Strong Association of β-Catenin With Cadherin Adherens Junctions in Resting Human Platelets.

Maguire PB, Donlon T, Parsons M, Wynne K, Dillon E, Ní Áinle F, Szklanna PB.

Proteomics. 2018 May;18(9):e1700419. doi: 10.1002/pmic.201700419.


Peptidomic screening of bitter and nonbitter casein hydrolysate fractions for insulinogenic peptides.

Murray NM, O'Riordan D, Jacquier JC, O'Sullivan M, Holton TA, Wynne K, Robinson RC, Barile D, Nielsen SD, Dallas DC.

J Dairy Sci. 2018 Apr;101(4):2826-2837. doi: 10.3168/jds.2017-13853. Epub 2018 Feb 7.


Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort.

English JA, Lopez LM, O'Gorman A, Föcking M, Hryniewiecka M, Scaife C, Sabherwal S, Wynne K, Dicker P, Rutten BPF, Lewis G, Zammit S, Cannon M, Cagney G, Cotter DR.

Schizophr Bull. 2018 Feb 15;44(2):297-306. doi: 10.1093/schbul/sbx075.


The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis.

Farrelly L, Rosato-Siri MV, Föcking M, Codagnone M, Reines A, Dicker P, Wynne K, Farrell M, Cannon M, Cagney G, Pasquini JM, Cotter DR.

Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600407.


Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP.

EMBO J. 2017 Aug 1;36(15):2216-2232. doi: 10.15252/embj.201696307. Epub 2017 May 29.


Effect of platelet-derived β-thromboglobulins on coagulation.

Egan K, van Geffen JP, Ma H, Kevane B, Lennon A, Allen S, Neary E, Parsons M, Maguire P, Wynne K, O' Kennedy R, Heemskerk JWM, Áinle FN.

Thromb Res. 2017 Jun;154:7-15. doi: 10.1016/j.thromres.2017.03.023. Epub 2017 Mar 30.


Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.

Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G.

ACS Chem Neurosci. 2017 May 17;8(5):1101-1116. doi: 10.1021/acschemneuro.6b00437. Epub 2017 Apr 21.


Comparative proteomic analysis of trophoblast cell models reveals their differential phenotypes, potential uses, and limitations.

Szklanna PB, Wynne K, Nolan M, Egan K, Áinle FN, Maguire PB.

Proteomics. 2017 May;17(10):e1700037. doi: 10.1002/pmic.201700037.


SerpinI2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin.

Higgins WJ, Grehan GT, Wynne KJ, Worrall DM.

Biochim Biophys Acta Proteins Proteom. 2017 Feb;1865(2):195-200. doi: 10.1016/j.bbapap.2016.10.013. Epub 2016 Oct 27.


Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

Oliviero G, Brien GL, Waston A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Wynne K, Crean J, Bracken AP, Cagney G.

Mol Cell Proteomics. 2016 Nov;15(11):3450-3460. Epub 2016 Sep 15.

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