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Items: 1 to 20 of 83


Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose.

Su J, Cui L, Si Y, Song C, Li Y, Yang T, Wang H, Mayo KH, Tai G, Zhou Y.

Biosci Rep. 2018 Dec 14;38(6). pii: BSR20181787. doi: 10.1042/BSR20181787. Print 2018 Dec 21.


Galectin-3 binds selectively to the terminal, non-reducing end of β(1→4)-galactans, with overall affinity increasing with chain length.

Miller MC, Zheng Y, Zhou Y, Tai G, Mayo KH.

Glycobiology. 2019 Jan 1;29(1):74-84. doi: 10.1093/glycob/cwy085.


Preparation of individual galactan oligomers, their prebiotic effects, and use in estimating galactan chain length in pectin-derived polysaccharides.

Zheng Y, Li L, Feng Z, Wang H, Mayo KH, Zhou Y, Tai G.

Carbohydr Polym. 2018 Nov 1;199:526-533. doi: 10.1016/j.carbpol.2018.07.048. Epub 2018 Jul 17.


An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature.

Huijbers EJM, van Beijnum JR, Lê CT, Langman S, Nowak-Sliwinska P, Mayo KH, Griffioen AW.

Vaccine. 2018 May 17;36(21):3054-3060. doi: 10.1016/j.vaccine.2018.03.064. Epub 2018 Apr 11.


Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008.

Paz H, Joo EJ, Chou CH, Fei F, Mayo KH, Abdel-Azim H, Ghazarian H, Groffen J, Heisterkamp N.

J Exp Clin Cancer Res. 2018 Mar 27;37(1):67. doi: 10.1186/s13046-018-0721-7.


Galectins as Molecular Targets for Therapeutic Intervention.

Dings RPM, Miller MC, Griffin RJ, Mayo KH.

Int J Mol Sci. 2018 Mar 19;19(3). pii: E905. doi: 10.3390/ijms19030905. Review.


Adhesion/growth-regulatory galectins tested in combination: evidence for formation of hybrids as heterodimers.

Miller MC, Ludwig AK, Wichapong K, Kaltner H, Kopitz J, Gabius HJ, Mayo KH.

Biochem J. 2018 Mar 15;475(5):1003-1018. doi: 10.1042/BCJ20170658.


Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function.

Zhang T, Miller MC, Zheng Y, Zhang Z, Xue H, Zhao D, Su J, Mayo KH, Zhou Y, Tai G.

Biochem J. 2017 Nov 9;474(22):3849-3868. doi: 10.1042/BCJ20170143.


Chemokines from a Structural Perspective.

Miller MC, Mayo KH.

Int J Mol Sci. 2017 Oct 2;18(10). pii: E2088. doi: 10.3390/ijms18102088. Review.


Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization.

Miller MC, Zheng Y, Yan J, Zhou Y, Tai G, Mayo KH.

Glycobiology. 2017 Nov 1;27(11):1038-1051. doi: 10.1093/glycob/cwx071.


Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaah6650. doi: 10.1126/scitranslmed.aah6650.


Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation.

Agten SM, Koenen RR, Ippel H, Eckardt V, von Hundelshausen P, Mayo KH, Weber C, Hackeng TM.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14963-14966. doi: 10.1002/anie.201607036. Epub 2016 Oct 27.


Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR.

Ippel H, Miller MC, Vértesy S, Zheng Y, Cañada FJ, Suylen D, Umemoto K, Romanò C, Hackeng T, Tai G, Leffler H, Kopitz J, André S, Kübler D, Jiménez-Barbero J, Oscarson S, Gabius HJ, Mayo KH.

Glycobiology. 2016 Aug;26(8):888-903. doi: 10.1093/glycob/cww021. Epub 2016 Feb 23.


Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain.

Miller MC, Ippel H, Suylen D, Klyosov AA, Traber PG, Hackeng T, Mayo KH.

Glycobiology. 2016 Jan;26(1):88-99. doi: 10.1093/glycob/cwv073.


Evaluation of 111In-labeled Anginex as Potential SPECT Tracer for Imaging of Tumor Angiogenesis.

Van Mourik TR, Läppchen T, Rossin R, Van Beijnum JR, Macdonald JR, Mayo KH, Griffioen AW, Nicolay K, Grüll H.

Anticancer Res. 2015 Nov;35(11):5945-54.


Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence.

Vértesy S, Michalak M, Miller MC, Schnölzer M, André S, Kopitz J, Mayo KH, Gabius HJ.

Protein Eng Des Sel. 2015 Jul;28(7):199-210. doi: 10.1093/protein/gzv014. Epub 2015 Mar 21.


Novel analogs of antitumor agent calixarene 0118: Synthesis, cytotoxicity, click labeling with 2-[(18)F]fluoroethylazide, and in vivo evaluation.

Läppchen T, Dings RP, Rossin R, Simon JF, Visser TJ, Bakker M, Walhe P, van Mourik T, Donato K, van Beijnum JR, Griffioen AW, Lub J, Robillard MS, Mayo KH, Grüll H.

Eur J Med Chem. 2015 Jan 7;89:279-95. doi: 10.1016/j.ejmech.2014.10.048. Epub 2014 Oct 18.


Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis.

Rauthu SR, Shiao TC, André S, Miller MC, Madej É, Mayo KH, Gabius HJ, Roy R.

Chembiochem. 2015 Jan 2;16(1):126-39. doi: 10.1002/cbic.201402474. Epub 2014 Nov 18.


(1)H, (13)C, and (15)N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3.

Ippel H, Miller MC, Berbís MA, Suylen D, André S, Hackeng TM, Cañada FJ, Weber C, Gabius HJ, Jiménez-Barbero J, Mayo KH.

Biomol NMR Assign. 2015 Apr;9(1):59-63. doi: 10.1007/s12104-014-9545-3. Epub 2014 Feb 7.


Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner.

Berbís MÁ, André S, Cañada FJ, Pipkorn R, Ippel H, Mayo KH, Kübler D, Gabius HJ, Jiménez-Barbero J.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):126-31. doi: 10.1016/j.bbrc.2013.11.063. Epub 2013 Nov 22.

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