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Items: 1 to 20 of 21


High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H.

Sci Rep. 2020 Jan 14;10(1):235. doi: 10.1038/s41598-019-57143-x.


High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry.

Kaldmäe M, Leppert A, Chen G, Sarr M, Sahin C, Nordling K, Kronqvist N, Gonzalvo-Ulla M, Fritz N, Abelein A, Laίn S, Biverstål H, Jörnvall H, Lane DP, Rising A, Johansson J, Landreh M.

FEBS J. 2019 Dec 9. doi: 10.1111/febs.15169. [Epub ahead of print]


Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy.

Otikovs M, Andersson M, Jia Q, Nordling K, Meng Q, Andreas LB, Pintacuda G, Johansson J, Rising A, Jaudzems K.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12571-12575. doi: 10.1002/anie.201706649. Epub 2017 Aug 30.


Systemic AA amyloidosis in the red fox (Vulpes vulpes).

Rising A, Cederlund E, Palmberg C, Uhlhorn H, Gaunitz S, Nordling K, Ågren E, Ihse E, Westermark GT, Tjernberg L, Jörnvall H, Johansson J, Westermark P.

Protein Sci. 2017 Nov;26(11):2312-2318. doi: 10.1002/pro.3264. Epub 2017 Sep 13.


Efficient protein production inspired by how spiders make silk.

Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J.

Nat Commun. 2017 May 23;8:15504. doi: 10.1038/ncomms15504.


Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains.

Otikovs M, Chen G, Nordling K, Landreh M, Meng Q, Jörnvall H, Kronqvist N, Rising A, Johansson J, Jaudzems K.

Chembiochem. 2015 Aug 17;16(12):1720-4. doi: 10.1002/cbic.201500263. Epub 2015 Jul 1.


Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.

Andersson M, Chen G, Otikovs M, Landreh M, Nordling K, Kronqvist N, Westermark P, Jörnvall H, Knight S, Ridderstråle Y, Holm L, Meng Q, Jaudzems K, Chesler M, Johansson J, Rising A.

PLoS Biol. 2014 Aug 5;12(8):e1001921. doi: 10.1371/journal.pbio.1001921. eCollection 2014 Aug.


Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.

Kronqvist N, Otikovs M, Chmyrov V, Chen G, Andersson M, Nordling K, Landreh M, Sarr M, Jörnvall H, Wennmalm S, Widengren J, Meng Q, Rising A, Otzen D, Knight SD, Jaudzems K, Johansson J.

Nat Commun. 2014;5:3254. doi: 10.1038/ncomms4254.


pH-dependent dimerization of spider silk N-terminal domain requires relocation of a wedged tryptophan side chain.

Jaudzems K, Askarieh G, Landreh M, Nordling K, Hedhammar M, Jörnvall H, Rising A, Knight SD, Johansson J.

J Mol Biol. 2012 Sep 28;422(4):477-87. doi: 10.1016/j.jmb.2012.06.004. Epub 2012 Jun 15.


High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.

Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H, Hermansson E, Hamvas A, Nogee LM, Bergman T, Saenz A, Casals C, Åqvistg J, Jörnvall H, Berglund H, Presto J, Knight SD, Johansson J.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2325-9. doi: 10.1073/pnas.1114740109. Epub 2012 Feb 2.


A pH-dependent dimer lock in spider silk protein.

Landreh M, Askarieh G, Nordling K, Hedhammar M, Rising A, Casals C, Astorga-Wells J, Alvelius G, Knight SD, Johansson J, Jörnvall H, Bergman T.

J Mol Biol. 2010 Nov 26;404(2):328-36. doi: 10.1016/j.jmb.2010.09.054. Epub 2010 Sep 29.


Self-assembly of spider silk proteins is controlled by a pH-sensitive relay.

Askarieh G, Hedhammar M, Nordling K, Saenz A, Casals C, Rising A, Johansson J, Knight SD.

Nature. 2010 May 13;465(7295):236-8. doi: 10.1038/nature08962.


Sterilized recombinant spider silk fibers of low pyrogenicity.

Hedhammar M, Bramfeldt H, Baris T, Widhe M, Askarieh G, Nordling K, Aulock Sv, Johansson J.

Biomacromolecules. 2010 Apr 12;11(4):953-9. doi: 10.1021/bm9014039.


Peptide-binding specificity of the prosurfactant protein C Brichos domain analyzed by electrospray ionization mass spectrometry.

Fitzen M, Alvelius G, Nordling K, Jörnvall H, Bergman T, Johansson J.

Rapid Commun Mass Spectrom. 2009 Nov;23(22):3591-8. doi: 10.1002/rcm.4282.


The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment.

Johansson H, Eriksson M, Nordling K, Presto J, Johansson J.

Protein Sci. 2009 Jun;18(6):1175-82. doi: 10.1002/pro.123.


Inactivation of pulmonary surfactant by silicone oil in vitro and in ventilated immature rabbits.

Stichtenoth G, Linderholm B, Almlén A, Björkman MH, Byman I, Nordling K, Robertson B, Johansson J, Herting E, Curstedt T.

Crit Care Med. 2009 May;37(5):1750-6. doi: 10.1097/CCM.0b013e31819fb42c.


Anti-amyloid activity of the C-terminal domain of proSP-C against amyloid beta-peptide and medin.

Nerelius C, Gustafsson M, Nordling K, Larsson A, Johansson J.

Biochemistry. 2009 May 5;48(17):3778-86. doi: 10.1021/bi900135c.


Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C.

Nerelius C, Martin E, Peng S, Gustafsson M, Nordling K, Weaver T, Johansson J.

Biochem J. 2008 Dec 1;416(2):201-9. doi: 10.1042/BJ20080981.


Structural properties of recombinant nonrepetitive and repetitive parts of major ampullate spidroin 1 from Euprosthenops australis: implications for fiber formation.

Hedhammar M, Rising A, Grip S, Martinez AS, Nordling K, Casals C, Stark M, Johansson J.

Biochemistry. 2008 Mar 18;47(11):3407-17. doi: 10.1021/bi702432y. Epub 2008 Feb 23.


C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C - structural features and membrane interactions.

Casals C, Johansson H, Saenz A, Gustafsson M, Alfonso C, Nordling K, Johansson J.

FEBS J. 2008 Feb;275(3):536-47. doi: 10.1111/j.1742-4658.2007.06220.x.

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