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Items: 1 to 20 of 109

1.

Effects of Pregnancy on the Pharmacokinetics of Metformin.

Liao MZ, Flood Nichols SK, Ahmed M, Clark S, Hankins GD, Caritis S, Venkataramanan R, Haas D, Quinney SK, Haneline LS, Tita AT, Manuck T, Wang J, Thummel KE, Brown LM, Ren Z, Easterling TR, Hebert MF.

Drug Metab Dispos. 2020 Jan 24. pii: dmd.119.088435. doi: 10.1124/dmd.119.088435. [Epub ahead of print]

2.

Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Brown LM, Ren Z, Brown Z, Easterling TR, Hebert MF.

Clin Pharmacol Ther. 2019 Dec 23. doi: 10.1002/cpt.1749. [Epub ahead of print]

PMID:
31869430
3.

Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF.

J Clin Pharmacol. 2019 Nov 19. doi: 10.1002/jcph.1549. [Epub ahead of print]

PMID:
31742716
4.

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.

Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL.

Clin Transl Sci. 2020 Jan;13(1):147-156. doi: 10.1111/cts.12695. Epub 2019 Oct 25.

5.

Tissue Chips in Space-Challenges and Opportunities.

Yeung CK, Koenig P, Countryman S, Thummel KE, Himmelfarb J, Kelly EJ.

Clin Transl Sci. 2020 Jan;13(1):8-10. doi: 10.1111/cts.12689. Epub 2019 Sep 16. No abstract available.

6.

Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K.

Yin J, Wagner DJ, Prasad B, Isoherranen N, Thummel KE, Wang J.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F805-F814. doi: 10.1152/ajprenal.00141.2019. Epub 2019 Jul 19.

PMID:
31322418
7.

Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations.

Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF.

Nicotine Tob Res. 2019 Jun 25. pii: ntz105. doi: 10.1093/ntr/ntz105. [Epub ahead of print]

PMID:
31241144
8.

Calling Star Alleles With Stargazer in 28 Pharmacogenes With Whole Genome Sequences.

Lee SB, Wheeler MM, Thummel KE, Nickerson DA.

Clin Pharmacol Ther. 2019 Dec;106(6):1328-1337. doi: 10.1002/cpt.1552. Epub 2019 Jul 26.

9.

Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.

Martineau AR, Thummel KE, Wang Z, Jolliffe DA, Boucher BJ, Griffin SJ, Forouhi NG, Hitman GA.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):5831-5839. doi: 10.1210/jc.2019-00207.

10.

VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People.

Henderson LM, Robinson RF, Ray L, Khan BA, Li T, Dillard DA, Schilling BD, Mosley M, Janssen PL, Fohner AE, Rettie AE, Thummel KE, Thornton TA, Veenstra DL.

Clin Transl Sci. 2019 May;12(3):312-320. doi: 10.1111/cts.12611. Epub 2019 Mar 1.

11.

Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system

Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE.

ALTEX. 2018;35(4):504-515. doi: 10.14573/altex.1803161. Epub 2018 Jul 8.

12.

Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model.

Lee SB, Wheeler MM, Patterson K, McGee S, Dalton R, Woodahl EL, Gaedigk A, Thummel KE, Nickerson DA.

Genet Med. 2019 Feb;21(2):361-372. doi: 10.1038/s41436-018-0054-0. Epub 2018 Jun 6.

13.

Prednisone Pharmacokinetics During Pregnancy and Lactation.

Ryu RJ, Easterling TR, Caritis SN, Venkataramanan R, Umans JG, Ahmed MS, Clark S, Kantrowitz-Gordon I, Hays K, Bennett B, Honaker MT, Thummel KE, Shen DD, Hebert MF.

J Clin Pharmacol. 2018 Sep;58(9):1223-1232. doi: 10.1002/jcph.1122. Epub 2018 May 7.

14.

Hepatic Transport of 25-Hydroxyvitamin D3 Conjugates: A Mechanism of 25-Hydroxyvitamin D3 Delivery to the Intestinal Tract.

Gao C, Liao MZ, Han LW, Thummel KE, Mao Q.

Drug Metab Dispos. 2018 May;46(5):581-591. doi: 10.1124/dmd.117.078881. Epub 2018 Feb 21.

15.

CYP3A4 mutation causes vitamin D-dependent rickets type 3.

Roizen JD, Li D, O'Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda CP, Thummel KE, Thacher TD, Hakonarson H, Levine MA.

J Clin Invest. 2018 May 1;128(5):1913-1918. doi: 10.1172/JCI98680. Epub 2018 Apr 3.

16.

Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People.

Khan BA, Robinson R, Fohner AE, Muzquiz LI, Schilling BD, Beans JA, Olnes MJ, Trawicki L, Frydenlund H, Laukes C, Beatty P, Phillips B, Nickerson D, Howlett K, Dillard DA, Thornton TA, Thummel KE, Woodahl EL.

Clin Transl Sci. 2018 May;11(3):312-321. doi: 10.1111/cts.12542. Epub 2018 Feb 13.

17.

P450 Pharmacogenetics in Indigenous North American Populations.

Henderson LM, Claw KG, Woodahl EL, Robinson RF, Boyer BB, Burke W, Thummel KE.

J Pers Med. 2018 Feb 1;8(1). pii: E9. doi: 10.3390/jpm8010009. Review.

18.

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Wong T, Wang Z, Chapron BD, Suzuki M, Claw KG, Gao C, Foti RS, Prasad B, Chapron A, Calamia J, Chaudhry A, Schuetz EG, Horst RL, Mao Q, de Boer IH, Thornton TA, Thummel KE.

Drug Metab Dispos. 2018 Apr;46(4):367-379. doi: 10.1124/dmd.117.078428. Epub 2018 Jan 17.

19.

Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.

Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF.

Pharmacogenet Genomics. 2018 Jan;28(1):7-16. doi: 10.1097/FPC.0000000000000317.

20.

Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska.

Au NT, Ryman T, Rettie AE, Hopkins SE, Boyer BB, Black J, Philip J, Yracheta J, Fohner AE, Reyes M, Thornton TA, Austin MA, Thummel KE.

Mol Nutr Food Res. 2018 Feb;62(3). doi: 10.1002/mnfr.201700746. Epub 2017 Dec 29.

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