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Items: 1 to 20 of 180

1.

Higher systemic exposure to unbound active metabolites of regorafenib is associated with short progression-free survival in colorectal cancer patients.

Kubota Y, Fujita KI, Takahashi T, Sunakawa Y, Ishida H, Hamada K, Ichikawa W, Tsunoda T, Shimada K, Masuo Y, Kato Y, Sasaki Y.

Clin Pharmacol Ther. 2020 Feb 8. doi: 10.1002/cpt.1810. [Epub ahead of print]

PMID:
32034953
2.

High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells.

Higurashi M, Maruyama T, Nogami Y, Ishikawa F, Yoshida Y, Mori K, Fujita KI, Shibanuma M.

Exp Cell Res. 2020 Feb 4:111889. doi: 10.1016/j.yexcr.2020.111889. [Epub ahead of print]

PMID:
32032602
3.

Deletion of the Golgi Ca2+-ATPase PMR1 gene potentiates antifungal effects of dodecanol that depend on intracellular Ca2+ accumulation in budding yeast.

Oyama M, Tamaki H, Yamaguchi Y, Ogita A, Tanaka T, Fujita KI.

FEMS Yeast Res. 2020 Feb 1;20(1). pii: foaa003. doi: 10.1093/femsyr/foaa003.

PMID:
31942998
4.

URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.

Fujita KI, Yamazaki T, Harada K, Seno S, Matsuda H, Masuda S.

Biochim Biophys Acta Gene Regul Mech. 2020 Feb;1863(2):194480. doi: 10.1016/j.bbagrm.2020.194480. Epub 2020 Jan 7.

PMID:
31917363
5.

Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites.

Kurata M, Fujiwara N, Fujita KI, Yamanaka Y, Seno S, Kobayashi H, Miyamae Y, Takahashi N, Shibuya Y, Masuda S.

iScience. 2019 Dec 20;22:336-352. doi: 10.1016/j.isci.2019.11.033. Epub 2019 Nov 20.

6.

High-throughput method to analyze tegafur and 5-fluorouracil in human tears and plasma using hydrophilic interaction liquid chromatography/tandem mass spectrometry.

Shiokawa R, Lee XP, Yamada M, Fujishiro M, Sakamaki H, Hasegawa C, Ishida H, Ikeda K, Fujita KI, Iwabuchi S, Onda H, Kumazawa T, Sasaki Y, Sato K, Matsuyama T.

Rapid Commun Mass Spectrom. 2019 Dec 30;33(24):1906-1914. doi: 10.1002/rcm.8531.

PMID:
31323696
7.

Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.

Sekido M, Fujita KI, Kubota Y, Ishida H, Takahashi T, Ohkuma R, Tsunoda T, Ishikawa F, Shibanuma M, Sasaki Y.

Cancer Chemother Pharmacol. 2019 Jun;83(6):1127-1135. doi: 10.1007/s00280-019-03837-y. Epub 2019 Apr 9.

PMID:
30972456
8.

Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38.

Iwase M, Fujita KI, Nishimura Y, Seba N, Masuo Y, Ishida H, Kato Y, Kiuchi Y.

Cancer Chemother Pharmacol. 2019 May;83(5):993-998. doi: 10.1007/s00280-019-03784-8. Epub 2019 Feb 13.

PMID:
30810774
9.

Influx and Efflux Transporters Contribute to the Increased Dermal Exposure to Active Metabolite of Regorafenib After Repeated Oral Administration in Mice.

Al-Shammari AH, Masuo Y, Fujita KI, Yoshikawa Y, Nakamichi N, Kubota Y, Sasaki Y, Kato Y.

J Pharm Sci. 2019 Jun;108(6):2173-2179. doi: 10.1016/j.xphs.2019.01.018. Epub 2019 Jan 24.

PMID:
30685396
10.

Evaluation of Inhibitory Activities of UK-2A, an Antimycin-Type Antibiotic, and Its Synthetic Analogues against the Production of Anti-inflammatory Cytokine IL-4.

Usuki Y, Ishii S, Ijiri M, Yoshida KI, Satoh T, Horigome S, Yoshida I, Mishima T, Fujita KI.

J Nat Prod. 2018 Nov 26;81(11):2590-2594. doi: 10.1021/acs.jnatprod.8b00559. Epub 2018 Nov 12.

PMID:
30417645
11.

KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR.

Nakatani K, Yamaoka T, Ohba M, Fujita KI, Arata S, Kusumoto S, Taki-Takemoto I, Kamei D, Iwai S, Tsurutani J, Ohmori T.

Mol Cancer Ther. 2019 Jan;18(1):112-126. doi: 10.1158/1535-7163.MCT-18-0591. Epub 2018 Oct 15.

12.

Coadministration of cytotoxic chemotherapeutic agents with irinotecan is a risk factor for irinotecan-induced cholinergic syndrome in Japanese patients with cancer.

Tsuboya A, Fujita KI, Kubota Y, Ishida H, Taki-Takemoto I, Kamei D, Iwai S, Sasaki Y.

Int J Clin Oncol. 2019 Feb;24(2):222-230. doi: 10.1007/s10147-018-1347-7. Epub 2018 Sep 22.

PMID:
30244364
13.

123I-iomazenil whole-body imaging to detect hepatic carboxylesterase drug-metabolizing enzyme activity.

Mizutani A, Kobayashi M, Fujita KI, Takahashi K, Hokama T, Takasu H, Nishi K, Nishii R, Shikano N, Fukuchi K, Kawai K.

Nucl Med Commun. 2018 Sep;39(9):825-833. doi: 10.1097/MNM.0000000000000875.

PMID:
29877992
14.

Effect of nagilactone E on cell morphology and glucan biosynthesis in budding yeast Saccharomyces cerevisiae.

Hayashi K, Yamaguchi Y, Ogita A, Tanaka T, Kubo I, Fujita KI.

Fitoterapia. 2018 Jul;128:112-117. doi: 10.1016/j.fitote.2018.05.003. Epub 2018 May 14.

PMID:
29772300
15.

Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib.

Ellawatty WEA, Masuo Y, Fujita KI, Yamazaki E, Ishida H, Arakawa H, Nakamichi N, Abdelwahed R, Sasaki Y, Kato Y.

Drug Metab Dispos. 2018 Jan;46(1):33-40. doi: 10.1124/dmd.117.076554. Epub 2017 Oct 31.

PMID:
29089306
16.

Reversible Interconversion between 2,5-Dimethylpyrazine and 2,5-Dimethylpiperazine by Iridium-Catalyzed Hydrogenation/Dehydrogenation for Efficient Hydrogen Storage.

Fujita KI, Wada T, Shiraishi T.

Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10886-10889. doi: 10.1002/anie.201705452. Epub 2017 Jul 27.

PMID:
28748606
17.

Involvement of Irreversible Vacuolar Membrane Fragmentation in the Lethality of Food Emulsifier Diglycerol Monolaurate against Budding Yeast.

Ikegawa C, Ogita A, Doi T, Kumazawa F, Fujita KI, Tanaka T.

J Agric Food Chem. 2017 Jul 19;65(28):5650-5656. doi: 10.1021/acs.jafc.7b01580. Epub 2017 Jul 3.

PMID:
28671839
18.

Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites.

Fujita KI, Masuo Y, Yamazaki E, Shibutani T, Kubota Y, Nakamichi N, Sasaki Y, Kato Y.

J Pharm Sci. 2017 Sep;106(9):2632-2641. doi: 10.1016/j.xphs.2017.04.064. Epub 2017 May 4.

PMID:
28479358
19.

Vacuolar H+-ATPase subunit Vma1p functions as the molecular ligand in the vacuole-targeting fungicidal activity of polymyxin B.

Iida M, Yamada K, Nango Y, Yamaguchi Y, Ogita A, Fujita KI, Tanaka T.

Microbiology. 2017 Apr;163(4):531-540. doi: 10.1099/mic.0.000450.

PMID:
28443813
20.

Toxicities of Receptor Tyrosine Kinase Inhibitors in Cancer Pharmacotherapy: Management with Clinical Pharmacology.

Fujita KI, Ishida H, Kubota Y, Sasaki Y.

Curr Drug Metab. 2017;18(3):186-198. doi: 10.2174/1389200218666170105165832. Review.

PMID:
28059038

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