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Items: 1 to 20 of 22


Effects of insulin signaling on mouse taste cell proliferation.

Takai S, Watanabe Y, Sanematsu K, Yoshida R, Margolskee RF, Jiang P, Atsuta I, Koyano K, Ninomiya Y, Shigemura N.

PLoS One. 2019 Nov 12;14(11):e0225190. doi: 10.1371/journal.pone.0225190. eCollection 2019.


Expression of Renin-Angiotensin System Components in the Taste Organ of Mice.

Shigemura N, Takai S, Hirose F, Yoshida R, Sanematsu K, Ninomiya Y.

Nutrients. 2019 Sep 19;11(9). pii: E2251. doi: 10.3390/nu11092251.


Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.

Park J, Selvam B, Sanematsu K, Shigemura N, Shukla D, Procko E.

J Biol Chem. 2019 Mar 29;294(13):4759-4774. doi: 10.1074/jbc.RA118.006173. Epub 2019 Feb 5.


Diurnal Variation of Sweet Taste Recognition Thresholds Is Absent in Overweight and Obese Humans.

Sanematsu K, Nakamura Y, Nomura M, Shigemura N, Ninomiya Y.

Nutrients. 2018 Mar 2;10(3). pii: E297. doi: 10.3390/nu10030297.


Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae.

Yoshida R, Takai S, Sanematsu K, Margolskee RF, Shigemura N, Ninomiya Y.

Neuroscience. 2018 Jan 15;369:29-39. doi: 10.1016/j.neuroscience.2017.10.047. Epub 2017 Nov 4.


Leptin suppresses sweet taste responses of enteroendocrine STC-1 cells.

Jyotaki M, Sanematsu K, Shigemura N, Yoshida R, Ninomiya Y.

Neuroscience. 2016 Sep 22;332:76-87. doi: 10.1016/j.neuroscience.2016.06.036. Epub 2016 Jun 25.


Intracellular acidification is required for full activation of the sweet taste receptor by miraculin.

Sanematsu K, Kitagawa M, Yoshida R, Nirasawa S, Shigemura N, Ninomiya Y.

Sci Rep. 2016 Mar 10;6:22807. doi: 10.1038/srep22807.


Structure, function, and signaling of taste G-protein-coupled receptors.

Sanematsu K, Yoshida R, Shigemura N, Ninomiya Y.

Curr Pharm Biotechnol. 2014;15(10):951-61. Review.


Molecular mechanisms for sweet-suppressing effect of gymnemic acids.

Sanematsu K, Kusakabe Y, Shigemura N, Hirokawa T, Nakamura S, Imoto T, Ninomiya Y.

J Biol Chem. 2014 Sep 12;289(37):25711-20. doi: 10.1074/jbc.M114.560409. Epub 2014 Jul 23.


Angiotensin II modulates salty and sweet taste sensitivities.

Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, Yoshida R, Margolskee RF, Ninomiya Y.

J Neurosci. 2013 Apr 10;33(15):6267-77. doi: 10.1523/JNEUROSCI.5599-12.2013.


Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.

Li YJ, Kukita A, Watanabe T, Takano T, Qu P, Sanematsu K, Ninomiya Y, Kukita T.

Lab Invest. 2012 Dec;92(12):1777-87. doi: 10.1038/labinvest.2012.134. Epub 2012 Oct 8.


Modulation of sweet responses of taste receptor cells.

Yoshida R, Niki M, Jyotaki M, Sanematsu K, Shigemura N, Ninomiya Y.

Semin Cell Dev Biol. 2013 Mar;24(3):226-31. doi: 10.1016/j.semcdb.2012.08.004. Epub 2012 Aug 25. Review.


New frontiers in gut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin.

Horio N, Jyotaki M, Yoshida R, Sanematsu K, Shigemura N, Ninomiya Y.

J Pharmacol Sci. 2010;112(1):8-12. Review.


Endocannabinoids selectively enhance sweet taste.

Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):935-9. doi: 10.1073/pnas.0912048107. Epub 2009 Dec 22.


Genetically-increased taste cell population with G(alpha)-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice.

Yasumatsu K, Ohkuri T, Sanematsu K, Shigemura N, Katsukawa H, Sako N, Ninomiya Y.

BMC Neurosci. 2009 Dec 22;10:152. doi: 10.1186/1471-2202-10-152.


Genetic and molecular basis of individual differences in human umami taste perception.

Shigemura N, Shirosaki S, Sanematsu K, Yoshida R, Ninomiya Y.

PLoS One. 2009 Aug 21;4(8):e6717. doi: 10.1371/journal.pone.0006717.


Modulation and transmission of sweet taste information for energy homeostasis.

Sanematsu K, Horio N, Murata Y, Yoshida R, Ohkuri T, Shigemura N, Ninomiya Y.

Ann N Y Acad Sci. 2009 Jul;1170:102-6. doi: 10.1111/j.1749-6632.2009.03893.x.


Variation in umami perception and in candidate genes for the umami receptor in mice and humans.

Shigemura N, Shirosaki S, Ohkuri T, Sanematsu K, Islam AA, Ogiwara Y, Kawai M, Yoshida R, Ninomiya Y.

Am J Clin Nutr. 2009 Sep;90(3):764S-769S. doi: 10.3945/ajcn.2009.27462M. Epub 2009 Jul 22. Review.


Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels.

Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y.

Diabetes. 2008 Oct;57(10):2661-5. doi: 10.2337/db07-1103. Epub 2008 Jul 15.


Taste responsiveness of fungiform taste cells with action potentials.

Yoshida R, Shigemura N, Sanematsu K, Yasumatsu K, Ishizuka S, Ninomiya Y.

J Neurophysiol. 2006 Dec;96(6):3088-95. Epub 2006 Sep 13.

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