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Items: 1 to 20 of 249

1.

Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition.

Jiang X, He H, Xie Z, Wen H, Li X, Li X, Ma J, Umezawa K, Zhang Y.

Immunopharmacol Immunotoxicol. 2019 Feb 6:1-8. doi: 10.1080/08923973.2018.1510962. [Epub ahead of print]

PMID:
30724631
2.

Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.

Ohashi T, Nakade Y, Ibusuki M, Kitano R, Yamauchi T, Kimoto S, Inoue T, Kobayashi Y, Sumida Y, Ito K, Nakao H, Umezawa K, Yoneda M.

PLoS One. 2019 Jan 28;14(1):e0210068. doi: 10.1371/journal.pone.0210068. eCollection 2019.

3.

Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion.

Lin Y, Chen Y, Ukaji T, Okada S, Umezawa K.

J Antibiot (Tokyo). 2019 Mar;72(3):148-154. doi: 10.1038/s41429-018-0129-9. Epub 2018 Dec 3.

PMID:
30510246
4.

The plant alkaloid conophylline inhibits matrix formation of fibroblasts.

Tezuka T, Ota A, Karnan S, Matsuura K, Yokoo K, Hosokawa Y, Vigetti D, Passi A, Hatano S, Umezawa K, Watanabe H.

J Biol Chem. 2018 Dec 28;293(52):20214-20226. doi: 10.1074/jbc.RA118.005783. Epub 2018 Oct 30.

PMID:
30377255
5.

Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.

Ishii N, Araki K, Yokobori T, Hagiwara K, Gantumur D, Yamanaka T, Handa T, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Harimoto N, Masamune A, Umezawa K, Kuwano H, Shirabe K.

Cancer Sci. 2019 Jan;110(1):334-344. doi: 10.1111/cas.13847. Epub 2018 Dec 13.

6.

NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.

Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.

Mol Med Rep. 2018 Dec;18(6):5279-5285. doi: 10.3892/mmr.2018.9533. Epub 2018 Oct 3.

PMID:
30320338
7.

Carbapenem-resistant Klebsiella pneumoniae in a Febrile Neutropenia Patient With Acute Myelogenous Leukemia After Hematopoietic Stem Cell Transplantation.

Asai S, Ohshima T, Iwashita H, Ishii Y, Aoki K, Minakawa Y, Machida S, Umezawa K, Tateda K, Miyachi H.

Infect Dis Clin Pract (Baltim Md). 2018 Sep;26(5):e38-e39. doi: 10.1097/IPC.0000000000000633. Epub 2018 Apr 21. No abstract available.

8.

Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis.

Tachibana H, Kakino A, Kazama M, Feng M, Asai S, Umezawa K, Nozaki T, Makiuchi T, Kamada T, Watanabe H, Horiki N, Cheng X, Masuda G.

Parasitology. 2018 Dec;145(14):1890-1895. doi: 10.1017/S0031182018000690. Epub 2018 May 9.

PMID:
29739480
9.

Corrigendum to "poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells" [Biochim. Biophys. Acta 1853(12)(2015) 3224-3234].

Lampiasi N, Umezawa K, Montalto G, Cervello M.

Biochim Biophys Acta Mol Cell Res. 2018 Jul;1865(7):1023. doi: 10.1016/j.bbamcr.2018.04.004. Epub 2018 Apr 21. No abstract available.

PMID:
29685431
10.

DTCM-glutarimide Delays Growth and Radiosensitizes Glioblastoma.

Roberto GM, Paiva HH, Botelho de Souza LE, Pezuk JA, Vieira GM, de Oliveira HF, Umezawa K, Tone LG, Brassesco MS.

Anticancer Agents Med Chem. 2018;18(9):1323-1329. doi: 10.2174/1871520618666180423105740.

PMID:
29683097
11.

Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review.

Lin Y, Ukaji T, Koide N, Umezawa K.

Int J Mol Sci. 2018 Mar 3;19(3). pii: E729. doi: 10.3390/ijms19030729. Review.

12.

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models.

Umezawa K, Kojima I, Simizu S, Lin Y, Fukatsu H, Koide N, Nakade Y, Yoneda M.

Hum Cell. 2018 Apr;31(2):95-101. doi: 10.1007/s13577-017-0196-4. Epub 2017 Dec 16. Review.

PMID:
29249016
13.

The Implementation of a Hospital-wide Practice for the Selective Use of Carbapenems Based on the Monitoring of Susceptibility of Pseudomonas aeruginosa Isolates.

Ohshima T, Asai S, Miyazawa M, Yamamoto Y, Hisada A, Kumazawa C, Hashimoto M, Fukawa K, Iwashita H, Umezawa K, Yamada S, Yamamoto Y, Miyachi H.

Tokai J Exp Clin Med. 2017 Dec 20;42(4):176-181.

14.

Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines.

Ramos PMM, Pezuk JA, Castro-Gamero AM, Oliveira HF, Scrideli CA, Umezawa K, Tone LG.

Anticancer Agents Med Chem. 2018;18(4):541-549. doi: 10.2174/1871520617666171113151335.

PMID:
29141555
15.

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.

Simon-Gabriel CP, Foerster K, Saleem S, Bleckmann D, Benkisser-Petersen M, Thornton N, Umezawa K, Decker S, Burger M, Veelken H, Claus R, Dierks C, Duyster J, Zirlik K.

Haematologica. 2018 Jan;103(1):136-147. doi: 10.3324/haematol.2017.165381. Epub 2017 Nov 9.

16.

The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.

Fujii T, Fujita N, Suzuki S, Tsuji T, Takaki T, Umezawa K, Watanabe K, Miyamoto T, Horiuchi K, Matsumoto M, Nakamura M.

J Orthop Res. 2018 May;36(5):1334-1345. doi: 10.1002/jor.23787. Epub 2017 Nov 28.

PMID:
29080374
17.

Novel p-terphenyl glycoside with a rare 2,6-dideoxyhexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.

Wang L, Li M, Tang J, Lin Y, Sidthipong K, Sumida N, Kushida N, Umezawa K.

J Antibiot (Tokyo). 2017 Oct;70(10):987-990. doi: 10.1038/ja.2017.83. Epub 2017 Jul 19.

PMID:
28951608
18.

A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.

Tanaka A, Radwan MO, Hamasaki A, Ejima A, Obata E, Koga R, Tateishi H, Okamoto Y, Fujita M, Nakao M, Umezawa K, Tamanoi F, Otsuka M.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3862-3866. doi: 10.1016/j.bmcl.2017.06.047. Epub 2017 Jun 20.

PMID:
28666734
19.

Conophylline inhibits non-alcoholic steatohepatitis in mice.

Nakade Y, Sakamoto K, Yamauchi T, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Sumida Y, Ito K, Nakao H, Fukuzawa Y, Umezawa K, Yoneda M.

PLoS One. 2017 Jun 8;12(6):e0178436. doi: 10.1371/journal.pone.0178436. eCollection 2017.

20.

Clinical Serum Therapy: Benefits, Cautions, and Potential Applications.

Hifumi T, Yamamoto A, Ato M, Sawabe K, Morokuma K, Morine N, Kondo Y, Noda E, Sakai A, Takahashi J, Umezawa K.

Keio J Med. 2017 Dec 25;66(4):57-64. doi: 10.2302/kjm.2016-0017-IR. Epub 2017 Apr 28. Review.

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