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Items: 7


Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment.

Rushworth LK, Hewit K, Munnings-Tomes S, Somani S, James D, Shanks E, Duf├Ęs C, Straube A, Patel R, Leung HY.

Br J Cancer. 2019 Dec 17. doi: 10.1038/s41416-019-0681-5. [Epub ahead of print]


Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

Neidler S, Kruspig B, Hewit K, Monteverde T, Gyuraszova K, Braun A, Clark W, James D, Hedley A, Nieswandt B, Shanks E, Dick C, Murphy DJ.

Cancers (Basel). 2019 Apr 29;11(5). pii: E600. doi: 10.3390/cancers11050600.


A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor.

Hewit K, Sandilands E, Martinez RS, James D, Leung HY, Bryant DM, Shanks E, Markert EK.

Cell Death Dis. 2018 Oct 19;9(11):1069. doi: 10.1038/s41419-018-1115-7.


Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition.

Mitchell R, Hopcroft LEM, Baquero P, Allan EK, Hewit K, James D, Hamilton G, Mukhopadhyay A, O'Prey J, Hair A, Melo JV, Chan E, Ryan KM, Maguer-Satta V, Druker BJ, Clark RE, Mitra S, Herzyk P, Nicolini FE, Salomoni P, Shanks E, Calabretta B, Holyoake TL, Helgason GV.

J Natl Cancer Inst. 2018 May 1;110(5):467-478. doi: 10.1093/jnci/djx236.


Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland.

Wilson GJ, Hewit KD, Pallas KJ, Cairney CJ, Lee KM, Hansell CA, Stein T, Graham GJ.

Development. 2017 Jan 1;144(1):74-82. doi: 10.1242/dev.139733. Epub 2016 Nov 25.


The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.

Hewit KD, Fraser A, Nibbs RJ, Graham GJ.

J Biol Chem. 2014 May 2;289(18):12330-42. doi: 10.1074/jbc.M113.534545. Epub 2014 Mar 18.


An analysis of the function and expression of D6 on lymphatic endothelial cells.

McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ.

Blood. 2013 May 2;121(18):3768-77. doi: 10.1182/blood-2012-04-425314. Epub 2013 Mar 11.


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