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Nutrients. 2016 May 12;8(5). pii: E282. doi: 10.3390/nu8050282.

Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes.

Leiherer A1,2,3, Stoemmer K4, Muendlein A5,6, Saely CH7,8,9, Kinz E10,11, Brandtner EM12, Fraunberger P13,14, Drexel H15,16,17,18.

Author information

1
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch A-6800, Austria. andreas.leiherer@vivit.at.
2
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. andreas.leiherer@vivit.at.
3
Medical Central Laboratories, Feldkirch A-6800, Austria. andreas.leiherer@vivit.at.
4
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. kathrin.stoemmer@gmx.de.
5
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch A-6800, Austria. axel.muendlein@vivit.at.
6
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. axel.muendlein@vivit.at.
7
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch A-6800, Austria. christoph.saely@lkhf.at.
8
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. christoph.saely@lkhf.at.
9
Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch A-6800, Austria. christoph.saely@lkhf.at.
10
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch A-6800, Austria. elena.kinz@vivit.at.
11
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. elena.kinz@vivit.at.
12
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch A-6800, Austria. lilli.brandtner@vivit.at.
13
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. pfraunberger@mzl.at.
14
Medical Central Laboratories, Feldkirch A-6800, Austria. pfraunberger@mzl.at.
15
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch A-6800, Austria. vivit@lkhf.at.
16
Private University of the Principality of Liechtenstein, Triesen FL-9495, Liechtenstein. vivit@lkhf.at.
17
Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch A-6800, Austria. vivit@lkhf.at.
18
Drexel University College of Medicine, Philadelphia, PA 19104, USA. vivit@lkhf.at.

Abstract

Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a hypoxic environment in adipose tissue which leads to a profound change of gene expression in adipocytes. As a consequence, there is a dysregulation of metabolism and adipokine secretion in adipose tissue leading to the development of systemic inflammation and finally resulting in the onset of metabolic diseases. The flavonoid quercetin as well as other secondary plant metabolites also referred to as phytochemicals have anti-oxidant, anti-inflammatory, and anti-diabetic effects known to be protective in view of obesity-related-diseases. Nevertheless, its underlying molecular mechanism is still obscure and thus the focus of this study was to explore the influence of quercetin on human SGBS (Simpson Golabi Behmel Syndrome) adipocytes' gene expression. We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes. Thus, these results are explained by the recently proposed hypothesis that the protective effect of quercetin is not solely due to its free radical-scavenging activity but also to a direct effect on mitochondrial processes, and they demonstrate that quercetin might have the potential to counteract the development of obesity-associated complications.

KEYWORDS:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; ANGPTL4; CFD; ENO2; FNDC5; IL1B; PAI-1; PFKFB4; PFKP; SERPINE1; adipsin; angiopoietin-like 4; complement factor D; enolase 2; fibronectin type III domain-containing 5; interleukin-1β; irisin; phosopho-fructokinase; phytochemicals; plasminogen activator inhibitor-1; quercetin

PMID:
27187453
PMCID:
PMC4882695
DOI:
10.3390/nu8050282
[Indexed for MEDLINE]
Free PMC Article

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