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Items: 1 to 20 of 78

1.

Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge.

Choi H, Kudchodkar SB, Reuschel EL, Asija K, Borole P, Agarwal S, Van Gorder L, Reed CC, Gulendran G, Ramos S, Broderick KE, Kim JJ, Ugen KE, Kobinger G, Siegel DL, Weiner DB, Muthumani K.

Hum Vaccin Immunother. 2019 Dec 4:1-12. doi: 10.1080/21645515.2019.1688038. [Epub ahead of print]

PMID:
31799896
2.

In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity.

Wise MC, Xu Z, Tello-Ruiz E, Beck C, Trautz A, Patel A, Elliott ST, Chokkalingam N, Kim S, Kerkau MG, Muthumani K, Jiang J, Fisher PD, Ramos SJ, Smith TR, Mendoza J, Broderick KE, Montefiori DC, Ferrari G, Kulp DW, Humeau LM, Weiner DB.

J Clin Invest. 2020 Feb 3;130(2):827-837. doi: 10.1172/JCI132779.

3.

Characterization of skin blebs from intradermal jet injection: Ex-vivo studies.

Simmons JA, Davis J, Thomas J, Lopez J, Le Blanc A, Allison H, Slook H, Lewis P, Holtz J, Fisher P, Broderick KE, Marston JO.

J Control Release. 2019 Aug 10;307:200-210. doi: 10.1016/j.jconrel.2019.06.032. Epub 2019 Jun 26.

PMID:
31252035
4.

Integration of needle-free jet injection with advanced electroporation delivery enhances the magnitude, kinetics, and persistence of engineered DNA vaccine induced immune responses.

Jiang J, Ramos SJ, Bangalore P, Fisher P, Germar K, Lee BK, Williamson D, Kemme A, Schade E, McCoy J, Muthumani K, Weiner DB, Humeau LM, Broderick KE.

Vaccine. 2019 Jun 27;37(29):3832-3839. doi: 10.1016/j.vaccine.2019.05.054. Epub 2019 Jun 4.

5.

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques.

Jiang J, Banglore P, Cashman KA, Schmaljohn CS, Schultheis K, Pugh H, Nguyen J, Humeau LM, Broderick KE, Ramos SJ.

Hum Vaccin Immunother. 2019;15(9):2066-2074. doi: 10.1080/21645515.2019.1616499. Epub 2019 Jun 19.

6.

Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers.

Tebas P, Kraynyak KA, Patel A, Maslow JN, Morrow MP, Sylvester AJ, Knoblock D, Gillespie E, Amante D, Racine T, McMullan T, Jeong M, Roberts CC, Park YK, Boyer J, Broderick KE, Kobinger GP, Bagarazzi M, Weiner DB, Sardesai NY, White SM.

J Infect Dis. 2019 Jul 2;220(3):400-410. doi: 10.1093/infdis/jiz132.

PMID:
30891607
7.

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation.

Schommer NN, Nguyen J, Yung BS, Schultheis K, Muthumani K, Weiner DB, Humeau L, Broderick KE, Smith TRF.

Hum Gene Ther. 2019 Apr;30(4):523-533. doi: 10.1089/hum.2018.241.

8.

Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination.

Schultheis K, Schaefer H, Pugh HM, Yung BS, Oh J, Nguyen J, Humeau L, Broderick KE, Smith TRF.

J Vis Exp. 2019 Jan 20;(143). doi: 10.3791/58595.

PMID:
30735179
9.

Novel IFN-γ ELISpot reveals robust T cell responses elicited after influenza nucleoprotein DNA vaccination in New Zealand White rabbits.

Yung BS, Pugh H, Generotti AA, Phanhthilath N, Schultheis K, Muthumani K, Broderick KE, Smith TRF.

Vaccine. 2019 Feb 8;37(7):903-909. doi: 10.1016/j.vaccine.2019.01.006. Epub 2019 Jan 17.

10.

Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice.

Wang Y, Esquivel R, Flingai S, Schiller ZA, Kern A, Agarwal S, Chu J, Patel A, Sullivan K, Wise MC, Broderick KE, Hu L, Weiner DB, Klempner MS.

J Infect Dis. 2019 Mar 15;219(7):1146-1150. doi: 10.1093/infdis/jiy627.

PMID:
30476132
11.

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.

Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, Kobinger GP, He S, Qiu X, Kobasa D, Humeau L, Sardesai NY, Ahmed R, Weiner DB.

Cell Rep. 2018 Nov 13;25(7):1982-1993.e4. doi: 10.1016/j.celrep.2018.10.062.

12.

Protective Efficacy and Long-Term Immunogenicity in Cynomolgus Macaques by Ebola Virus Glycoprotein Synthetic DNA Vaccines.

Patel A, Reuschel EL, Kraynyak KA, Racine T, Park DH, Scott VL, Audet J, Amante D, Wise MC, Keaton AA, Wong G, Villarreal DO, Walters J, Muthumani K, Shedlock DJ, de La Vega MA, Plyler R, Boyer J, Broderick KE, Yan J, Khan AS, Jones S, Bello A, Soule G, Tran KN, He S, Tierney K, Qiu X, Kobinger GP, Sardesai NY, Weiner DB.

J Infect Dis. 2019 Jan 29;219(4):544-555. doi: 10.1093/infdis/jiy537.

PMID:
30304515
13.

Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo.

Duperret EK, Trautz A, Stoltz R, Patel A, Wise MC, Perales-Puchalt A, Smith T, Broderick KE, Masteller E, Kim JJ, Humeau L, Muthumani K, Weiner DB.

Cancer Res. 2018 Nov 15;78(22):6363-6370. doi: 10.1158/0008-5472.CAN-18-1429. Epub 2018 Oct 4.

14.

A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses.

Elliott STC, Keaton AA, Chu JD, Reed CC, Garman B, Patel A, Yan J, Broderick KE, Weiner DB.

Hum Gene Ther. 2018 Sep;29(9):1044-1055. doi: 10.1089/hum.2018.102.

15.

Delineating the Cellular Mechanisms Associated with Skin Electroporation.

Schultheis K, Smith TRF, Kiosses WB, Kraynyak KA, Wong A, Oh J, Broderick KE.

Hum Gene Ther Methods. 2018 Aug;29(4):177-188. doi: 10.1089/hgtb.2017.105. Epub 2018 Aug 10.

16.

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.

Hu X, Lu Z, Valentin A, Rosati M, Broderick KE, Sardesai NY, Marx PA, Mullins JI, Pavlakis GN, Felber BK.

Hum Vaccin Immunother. 2018;14(9):2163-2177. doi: 10.1080/21645515.2018.1489949. Epub 2018 Jul 12.

17.

DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination.

Hu X, Valentin A, Cai Y, Dayton F, Rosati M, Ramírez-Salazar EG, Kulkarni V, Broderick KE, Sardesai NY, Wyatt LS, Earl PL, Moss B, Mullins JI, Pavlakis GN, Felber BK.

Hum Gene Ther. 2018 Sep;29(9):1029-1043. doi: 10.1089/hum.2018.065. Epub 2018 Jun 21.

18.

Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.

Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK.

J Virol. 2018 Jul 17;92(15). pii: e00281-18. doi: 10.1128/JVI.00281-18. Print 2018 Aug 1.

19.

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections.

Elliott STC, Kallewaard NL, Benjamin E, Wachter-Rosati L, McAuliffe JM, Patel A, Smith TRF, Schultheis K, Park DH, Flingai S, Wise MC, Mendoza J, Ramos S, Broderick KE, Yan J, Humeau LM, Sardesai NY, Muthumani K, Zhu Q, Weiner DB.

NPJ Vaccines. 2017 Jul 6;2:18. doi: 10.1038/s41541-017-0020-x. eCollection 2017.

20.

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine.

Muthumani K, Griffin BD, Agarwal S, Kudchodkar SB, Reuschel EL, Choi H, Kraynyak KA, Duperret EK, Keaton AA, Chung C, Kim YK, Booth SA, Racine T, Yan J, Morrow MP, Jiang J, Lee B, Ramos S, Broderick KE, Reed CC, Khan AS, Humeau L, Ugen KE, Park YK, Maslow JN, Sardesai NY, Joseph Kim J, Kobinger GP, Weiner DB.

NPJ Vaccines. 2016 Nov 10;1:16021. doi: 10.1038/npjvaccines.2016.21. eCollection 2016.

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