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Nanomaterials (Basel). 2019 Aug 10;9(8). pii: E1146. doi: 10.3390/nano9081146.

The Comprehensive Approach to Preparation and Investigation of the Eu3+ Doped Hydroxyapatite/poly(L-lactide) Nanocomposites: Promising Materials for Theranostics Application.

Author information

1
Institute of Low Temperature and Structure Research, Polish Academy of Science, ul. Okolna 2, 50-422 Wroclaw, Poland.
2
Wroclaw University of Science and Technology, Polymer Engineering and Technology Division, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland.
3
Institute of Low Temperature and Structure Research, Polish Academy of Science, ul. Okolna 2, 50-422 Wroclaw, Poland. r.wiglusz@intibs.pl.
4
Centre for Advanced Materials and Smart Structures, Polish Academy of Sciences, Okolna 2, 50-950 Wroclaw, Poland. r.wiglusz@intibs.pl.

Abstract

In response to the need for new materials for theranostics application, the structural and spectroscopic properties of composites designed for medical applications, received in the melt mixing process, were evaluated. A composite based on medical grade poly(L-lactide) (PLLA) and calcium hydroxyapatite (HAp) doped with Eu3+ ions was obtained by using a twin screw extruder. Pure calcium Hap, as well as the one doped with Eu3+ ions, was prepared using the precipitation method and then used as a filler. XRPD (X-ray Powder Diffraction) and IR (Infrared) spectroscopy were applied to investigate the structural properties of the obtained materials. DSC (Differential Scanning Calorimetry) was used to assess the Eu3+ ion content on phase transitions in PLLA. The tensile properties were also investigated. The excitation, emission spectra as well as decay time were measured to determine the spectroscopic properties. The simplified Judd-Ofelt (J-O) theory was applied and a detailed analysis in connection with the observed structural and spectroscopic measurements was made and described.

KEYWORDS:

calcium hydroxyapatite nanopowders; nanocomposites; poly(L-lactide); rare earth ions; twin screw extrusion

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