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Items: 1 to 20 of 43

1.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Mangoni AA, Eynde JJV, Jampilek J, Hadjipavlou-Litina D, Liu H, Reynisson J, Sousa ME, Gomes PAC, Prokai-Tatrai K, Tuccinardi T, Sabatier JM, Luque FJ, Rautio J, Karaman R, Vasconcelos MH, Gemma S, Galdiero S, Hulme C, Collina S, Gütschow M, Kokotos G, Siciliano C, Capasso R, Agrofoglio LA, Ragno R, Muñoz-Torrero D.

Molecules. 2019 Jun 30;24(13). pii: E2415. doi: 10.3390/molecules24132415.

2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4.

Mangoni AA, Guillou C, Vanden Eynde JJ, Hulme C, Jampilek J, Li W, Prokai-Tatrai K, Rautio J, Collina S, Tuccinardi T, Sousa ME, Sabatier JM, Galdiero S, Karaman R, Kokotos G, Torri G, Luque FJ, Vasconcelos MH, Hadjipavlou-Litina D, Siciliano C, Gütschow M, Ragno R, Gomes PAC, Agrofoglio LA, Muñoz-Torrero D.

Molecules. 2018 Dec 31;24(1). pii: E130. doi: 10.3390/molecules24010130.

3.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3.

Mangoni AA, Tuccinardi T, Collina S, Vanden Eynde JJ, Muñoz-Torrero D, Karaman R, Siciliano C, de Sousa ME, Prokai-Tatrai K, Rautio J, Guillou C, Gütschow M, Galdiero S, Liu H, Agrofoglio LA, Sabatier JM, Hulme C, Kokotos G, You Q, Gomes PAC.

Molecules. 2018 Jun 30;23(7). pii: E1596. doi: 10.3390/molecules23071596. No abstract available.

4.

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy.

Prokai-Tatrai K, Nguyen V, Prokai L.

ACS Chem Neurosci. 2018 Nov 21;9(11):2528-2533. doi: 10.1021/acschemneuro.8b00184. Epub 2018 Jun 5.

5.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Muñoz-Torrero D, Mangoni AA, Liu H, Hulme C, Rautio J, Karaman R, de Sousa ME, Prokai-Tatrai K, Sabatier JM, Siciliano C, Luque FJ, Kokotos G, Ragno R, Collina S, Guillou C, Gütschow M, Agrofoglio LA.

Molecules. 2017 Dec 28;23(1). pii: E65. doi: 10.3390/molecules23010065.

6.

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease.

Tschiffely AE, Schuh RA, Prokai-Tatrai K, Ottinger MA, Prokai L.

Horm Behav. 2018 Feb;98:16-21. doi: 10.1016/j.yhbeh.2017.11.015. Epub 2017 Dec 22.

7.

Non-Feminizing Estrogens Do Not Exhibit Antidepressant-like Activity.

Prokai-Tatrai K, Nguyen V, Prokai L.

J Pharm Drug Res. 2016;1(1):1-6. Epub 2016 May 15.

8.

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery.

Merchenthaler I, Lane M, Sabnis G, Brodie A, Nguyen V, Prokai L, Prokai-Tatrai K.

Sci Rep. 2016 Aug 1;6:30721. doi: 10.1038/srep30721.

9.

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease.

Tschiffely AE, Schuh RA, Prokai-Tatrai K, Prokai L, Ottinger MA.

Horm Behav. 2016 Jul;83:39-44. doi: 10.1016/j.yhbeh.2016.05.009. Epub 2016 May 19.

10.

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders.

Prokai L, Nguyen V, Szarka S, Garg P, Sabnis G, Bimonte-Nelson HA, McLaughlin KJ, Talboom JS, Conrad CD, Shughrue PJ, Gould TD, Brodie A, Merchenthaler I, Koulen P, Prokai-Tatrai K.

Sci Transl Med. 2015 Jul 22;7(297):297ra113. doi: 10.1126/scitranslmed.aab1290.

11.
12.

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis.

Prokai L, Guo J, Prokai-Tatrai K.

Nat Protoc. 2014 Apr;9(4):882-95. doi: 10.1038/nprot.2014.052. Epub 2014 Mar 20.

13.

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs.

Prokai-Tatrai K, Nguyen V, Szarka S, Konya K, Prokai L.

Pharmaceutics. 2013;5(2):318-28. doi: 10.3390/pharmaceutics5020318.

14.

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma.

Prokai-Tatrai K, Xin H, Nguyen V, Szarka S, Blazics B, Prokai L, Koulen P.

Mol Pharm. 2013 Aug 5;10(8):3253-61. doi: 10.1021/mp400313u. Epub 2013 Jul 23.

15.

Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC-MS/MS.

Szarka S, Nguyen V, Prokai L, Prokai-Tatrai K.

Anal Bioanal Chem. 2013 Apr;405(10):3399-406. doi: 10.1007/s00216-013-6710-y. Epub 2013 Feb 1.

16.

Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation.

Prokai L, Rivera-Portalatin NM, Prokai-Tatrai K.

Int J Mol Sci. 2013 Jan 11;14(1):1443-54. doi: 10.3390/ijms14011443.

17.

Capture of the volatile carbonyl metabolite of flecainide on 2,4-dinitrophenylhydrazine cartridge for quantitation by stable-isotope dilution mass spectrometry coupled with chromatography.

Prokai L, Szarka S, Wang X, Prokai-Tatrai K.

J Chromatogr A. 2012 Apr 6;1232:281-7. doi: 10.1016/j.chroma.2012.01.067. Epub 2012 Jan 31.

18.

Relative quantitation of protein nitration by liquid chromatography-mass spectrometry using isotope-coded dimethyl labeling and chemoprecipitation.

Guo J, Prokai-Tatrai K, Prokai L.

J Chromatogr A. 2012 Apr 6;1232:266-75. doi: 10.1016/j.chroma.2011.12.100. Epub 2012 Jan 9.

19.

"All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect.

Prokai-Tatrai K, Szarka S, Nguyen V, Sahyouni F, Walker C, White S, Talamantes T, Prokai L.

Pharm Anal Acta. 2012;Suppl 7. doi: 10.4172/2153-2435.S7-002.

20.

Prodrug design for brain delivery of small- and medium-sized neuropeptides.

Prokai-Tatrai K, Prokai L.

Methods Mol Biol. 2011;789:313-36. doi: 10.1007/978-1-61779-310-3_21.

PMID:
21922418

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