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Items: 1 to 20 of 25

1.

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.

Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR Jr.

Molecules. 2018 Jul 26;23(8). pii: E1858. doi: 10.3390/molecules23081858.

2.

6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors.

Zhao XZ, Metifiot M, Smith SJ, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Curr Top Med Chem. 2016;16(4):435-40. Review.

PMID:
26268341
3.

Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.

Costi R, Métifiot M, Chung S, Cuzzucoli Crucitti G, Maddali K, Pescatori L, Messore A, Madia VN, Pupo G, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Corona A, Pommier Y, Marchand C, Di Santo R.

J Med Chem. 2014 Apr 24;57(8):3223-34. doi: 10.1021/jm5001503. Epub 2014 Apr 11.

4.

Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products.

Nomura W, Aikawa H, Ohashi N, Urano E, Métifiot M, Fujino M, Maddali K, Ozaki T, Nozue A, Narumi T, Hashimoto C, Tanaka T, Pommier Y, Yamamoto N, Komano JA, Murakami T, Tamamura H.

ACS Chem Biol. 2013 Oct 18;8(10):2235-44. doi: 10.1021/cb400495h. Epub 2013 Aug 15.

PMID:
23898787
5.

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7309-13. doi: 10.1016/j.bmcl.2012.10.088. Epub 2012 Oct 27.

6.

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR Jr, Hughes SH, Cherepanov P, Pommier Y.

ACS Chem Biol. 2013 Jan 18;8(1):209-17. doi: 10.1021/cb300471n. Epub 2012 Dec 24.

7.

Probing chelation motifs in HIV integrase inhibitors.

Agrawal A, DeSoto J, Fullagar JL, Maddali K, Rostami S, Richman DD, Pommier Y, Cohen SM.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2251-6. doi: 10.1073/pnas.1112389109. Epub 2012 Jan 27.

8.

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Chem Biol Drug Des. 2012 Feb;79(2):157-65. doi: 10.1111/j.1747-0285.2011.01270.x. Epub 2011 Dec 22.

PMID:
22107736
9.

Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143.

Métifiot M, Vandegraaff N, Maddali K, Naumova A, Zhang X, Rhodes D, Marchand C, Pommier Y.

AIDS. 2011 Jun 1;25(9):1175-8. doi: 10.1097/QAD.0b013e3283473599.

PMID:
21505303
10.

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase.

Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z.

ACS Med Chem Lett. 2011 Jan;2(1):63-67.

11.

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2011 May 15;21(10):2986-90. doi: 10.1016/j.bmcl.2011.03.047. Epub 2011 Mar 21.

12.

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.

Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2400-2. doi: 10.1016/j.bmcl.2011.02.069. Epub 2011 Feb 18.

13.

3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase.

Tang J, Maddali K, Metifiot M, Sham YY, Vince R, Pommier Y, Wang Z.

J Med Chem. 2011 Apr 14;54(7):2282-92. doi: 10.1021/jm1014378. Epub 2011 Mar 7.

14.

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.

Das BB, Dexheimer TS, Maddali K, Pommier Y.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19790-5. doi: 10.1073/pnas.1009814107. Epub 2010 Nov 1.

15.

Preparation and characterization of novel 4-bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars.

Yamada M, Yamashita M, Suyama T, Yamashita J, Asai K, Niimi T, Ozaki N, Fujie M, Maddali K, Nakamura S, Ohnishi K.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5943-6. doi: 10.1016/j.bmcl.2010.01.061. Epub 2010 Jan 21.

PMID:
20801031
16.

Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.

Bioorg Med Chem. 2010 Sep 15;18(18):6771-5. doi: 10.1016/j.bmc.2010.07.050. Epub 2010 Jul 25.

17.

Resistance to integrase inhibitors.

Métifiot M, Marchand C, Maddali K, Pommier Y.

Viruses. 2010 Jun 25;2(7):1347-66.

18.

Peptide HIV-1 integrase inhibitors from HIV-1 gene products.

Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H.

J Med Chem. 2010 Jul 22;53(14):5356-60. doi: 10.1021/jm1003528.

19.

Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited.

Tang J, Maddali K, Pommier Y, Sham YY, Wang Z.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3275-9. doi: 10.1016/j.bmcl.2010.04.048. Epub 2010 Apr 21.

PMID:
20457521
20.

Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir.

Métifiot M, Maddali K, Naumova A, Zhang X, Marchand C, Pommier Y.

Biochemistry. 2010 May 4;49(17):3715-22. doi: 10.1021/bi100130f.

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