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Items: 1 to 20 of 63

1.

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures.

Lindenblatt D, Nickelsen A, Applegate VM, Hochscherf J, Witulski B, Bouaziz Z, Marminon C, Bretner M, Le Borgne M, Jose J, Niefind K.

ACS Omega. 2019 Mar 19;4(3):5471-5478. doi: 10.1021/acsomega.8b03415. eCollection 2019 Mar 31.

2.

Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.

Voss M, Toelzer C, Bhandari DD, Parker JE, Niefind K.

J Struct Biol. 2019 Dec 1;208(3):107390. doi: 10.1016/j.jsb.2019.09.007. Epub 2019 Sep 21.

PMID:
31550533
3.

Design of CK2β-Mimicking Peptides as Tools To Study the CK2α/CK2β Interaction in Cancer Cells.

Lindenblatt D, Horn M, Götz C, Niefind K, Neundorf I, Pietsch M.

ChemMedChem. 2019 Apr 17;14(8):833-841. doi: 10.1002/cmdc.201800786. Epub 2019 Mar 12.

PMID:
30786177
4.

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis.

Bhandari DD, Lapin D, Kracher B, von Born P, Bautor J, Niefind K, Parker JE.

Nat Commun. 2019 Feb 15;10(1):772. doi: 10.1038/s41467-019-08783-0.

5.

Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.

Hochscherf J, Pietsch M, Tieu W, Kuan K, Abell AD, Gütschow M, Niefind K.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):480-489. doi: 10.1107/S2053230X1800537X. Epub 2018 Jul 26.

PMID:
30084397
6.

Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.

Pichlo C, Toelzer C, Chojnacki K, Öcal S, Uthoff M, Ruegenberg S, Hermanns T, Schacherl M, Denzel MS, Hofmann K, Niefind K, Baumann U.

Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):307-314. doi: 10.1107/S2053230X18005253. Epub 2018 Apr 24.

PMID:
29717999
7.

A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.

Schnitzler A, Gratz A, Bollacke A, Weyrich M, Kuckländer U, Wünsch B, Götz C, Niefind K, Jose J.

Pharmaceuticals (Basel). 2018 Feb 17;11(1). pii: E23. doi: 10.3390/ph11010023.

8.

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.

Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K.

Pharmaceuticals (Basel). 2017 Dec 13;10(4). pii: E98. doi: 10.3390/ph10040098.

9.

Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.

Niefind K, Bischoff N, Golub AG, Bdzhola VG, Balanda AO, Prykhod'ko AO, Yarmoluk SM.

Pharmaceuticals (Basel). 2017 Jan 11;10(1). pii: E9. doi: 10.3390/ph10010009.

10.

A novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases.

Tölzer C, Pal S, Watzlawick H, Altenbuchner J, Niefind K.

FEBS Lett. 2016 Jan;590(1):174-84. doi: 10.1002/1873-3468.12031. Epub 2015 Dec 28.

11.

A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2α Complex Structures.

Guerra B, Bischoff N, Bdzhola VG, Yarmoluk SM, Issinger OG, Golub AG, Niefind K.

ACS Chem Biol. 2015 Jul 17;10(7):1654-60. doi: 10.1021/acschembio.5b00235. Epub 2015 May 15.

PMID:
25961323
12.

Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells.

Guerra B, Rasmussen TD, Schnitzler A, Jensen HH, Boldyreff BS, Miyata Y, Marcussen N, Niefind K, Issinger OG.

Cancer Lett. 2015 Jan 28;356(2 Pt B):751-61. doi: 10.1016/j.canlet.2014.10.026. Epub 2014 Oct 28.

PMID:
25449433
13.

Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2β interaction.

Hochscherf J, Lindenblatt D, Steinkrüger M, Yoo E, Ulucan Ö, Herzig S, Issinger OG, Helms V, Götz C, Neundorf I, Niefind K, Pietsch M.

Anal Biochem. 2015 Jan 1;468:4-14. doi: 10.1016/j.ab.2014.09.003. Epub 2014 Sep 16.

PMID:
25233003
14.

Evidence for aggregation of protein kinase CK2 in the cell: a novel strategy for studying CK2 holoenzyme interaction by BRET(2).

Hübner GM, Larsen JN, Guerra B, Niefind K, Vrecl M, Issinger OG.

Mol Cell Biochem. 2014 Dec;397(1-2):285-93. doi: 10.1007/s11010-014-2196-y. Epub 2014 Aug 23.

PMID:
25148873
15.

The protein kinase CK2(Andante) holoenzyme structure supports proposed models of autoregulation and trans-autophosphorylation.

Schnitzler A, Olsen BB, Issinger OG, Niefind K.

J Mol Biol. 2014 May 1;426(9):1871-82. doi: 10.1016/j.jmb.2014.02.018. Epub 2014 Mar 1.

PMID:
24594356
16.

Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity.

Wagner S, Stuttmann J, Rietz S, Guerois R, Brunstein E, Bautor J, Niefind K, Parker JE.

Cell Host Microbe. 2013 Dec 11;14(6):619-30. doi: 10.1016/j.chom.2013.11.006.

17.
18.

First structure of protein kinase CK2 catalytic subunit with an effective CK2β-competitive ligand.

Raaf J, Guerra B, Neundorf I, Bopp B, Issinger OG, Jose J, Pietsch M, Niefind K.

ACS Chem Biol. 2013 May 17;8(5):901-7. doi: 10.1021/cb3007133. Epub 2013 Mar 18.

PMID:
23474121
19.

A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.

Enkvist E, Viht K, Bischoff N, Vahter J, Saaver S, Raidaru G, Issinger OG, Niefind K, Uri A.

Org Biomol Chem. 2012 Nov 21;10(43):8645-53. doi: 10.1039/c2ob26022k.

PMID:
23032938
20.

Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.

Klopffleisch K, Issinger OG, Niefind K.

Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):883-92. doi: 10.1107/S0907444912016587. Epub 2012 Jul 7.

PMID:
22868753

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