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Items: 1 to 20 of 45


Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways.

Yu AX, Xu ML, Yao P, Kwan KK, Liu YX, Duan R, Dong TT, Ko RK, Tsim KW.

FASEB J. 2020 Mar;34(3):4311-4328. doi: 10.1096/fj.201902319RRR. Epub 2020 Jan 21.


Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer.

Hu WH, Chan GK, Duan R, Wang HY, Kong XP, Dong TT, Tsim KW.

Cancers (Basel). 2019 Nov 20;11(12). pii: E1828. doi: 10.3390/cancers11121828.


Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents.

Huang Y, Kwan KKL, Leung KW, Yao P, Wang H, Dong TT, Tsim KWK.

J Ginseng Res. 2019 Oct;43(4):517-526. doi: 10.1016/j.jgr.2018.02.002. Epub 2018 Feb 12.


Shexiang Baoxin Pill, a Formulated Chinese Herbal Mixture, Induces Neuronal Differentiation of PC12 Cells: A Signaling Triggered by Activation of Protein Kinase A.

Xu ML, Zheng ZY, Xia YJ, Liu EY, Chan SK, Hu WH, Duan R, Dong TT, Zhan CS, Shang XH, Tsim KW.

Front Pharmacol. 2019 Oct 9;10:1130. doi: 10.3389/fphar.2019.01130. eCollection 2019.


Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells.

Luo Y, Xie HQ, Chen Y, Xia Y, Sha R, Liu Y, Ma Y, Xu T, Xu L, Wah-Keung Tsim K, Zhao B.

Chem Biol Interact. 2019 Aug 1;308:164-169. doi: 10.1016/j.cbi.2019.05.018. Epub 2019 May 14.


The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats.

Huang Y, Yao P, Leung KW, Wang H, Kong XP, Dong TTX, Chen Y, Qin QW, Tsim KWK.

Phytomedicine. 2018 Dec 31:152815. doi: 10.1016/j.phymed.2018.12.038. [Epub ahead of print]


Molecular characteristics and function study of TNF receptor-associated factor 5 from grouper (Epinephelus coioides).

Yang M, Han R, Ni LY, Luo XC, Li AX, Dan XM, Tsim KW, Li YW.

Fish Shellfish Immunol. 2019 Apr;87:730-736. doi: 10.1016/j.fsi.2019.02.018. Epub 2019 Feb 12.


Isoorientin derived from Gentiana veitchiorum Hemsl. flowers inhibits melanogenesis by down-regulating MITF-induced tyrosinase expression.

Wu QY, Wong ZC, Wang C, Fung AH, Wong EO, Chan GK, Dong TT, Chen Y, Tsim KW.

Phytomedicine. 2019 Apr;57:129-136. doi: 10.1016/j.phymed.2018.12.006. Epub 2018 Dec 10.


Binding of Resveratrol to Vascular Endothelial Growth Factor Suppresses Angiogenesis by Inhibiting the Receptor Signaling.

Hu WH, Duan R, Xia YT, Xiong QP, Wang HY, Chan GK, Liu SY, Dong TT, Qin QW, Tsim KW.

J Agric Food Chem. 2019 Jan 30;67(4):1127-1137. doi: 10.1021/acs.jafc.8b05977. Epub 2019 Jan 17.


The Yin-Yang Property of Chinese Medicinal Herbs Relates to Chemical Composition but Not Anti-Oxidative Activity: An Illustration Using Spleen-Meridian Herbs.

Huang Y, Yao P, Leung KW, Wang H, Kong XP, Wang L, Dong TTX, Chen Y, Tsim KWK.

Front Pharmacol. 2018 Nov 15;9:1304. doi: 10.3389/fphar.2018.01304. eCollection 2018.


Prenylated Flavonoids from Roots of Glycyrrhiza uralensis Induce Differentiation of B16-F10 Melanoma Cells.

Zheng Y, Wang H, Yang M, Peng G, Dong TTX, Xu ML, Tsim KWK.

Int J Mol Sci. 2018 Aug 16;19(8). pii: E2422. doi: 10.3390/ijms19082422.


Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling.

Hu WH, Wang HY, Kong XP, Xiong QP, Poon KK, Xu L, Duan R, Chan GK, Dong TT, Tsim KW.

FASEB J. 2019 Jan;33(1):532-544. doi: 10.1096/fj.201800750R. Epub 2018 Jul 10.


The Extracts and Major Compounds Derived from Astragali Radix Alter Mitochondrial Bioenergetics in Cultured Cardiomyocytes: Comparison of Various Polar Solvents and Compounds.

Huang Y, Kwan KKL, Leung KW, Wang H, Kong XP, Dong TTX, Tsim KWK.

Int J Mol Sci. 2018 May 25;19(6). pii: E1574. doi: 10.3390/ijms19061574.


The extract of Polygoni Cuspidati Rhizoma et Radix suppresses the vascular endothelial growth factor-induced angiogenesis.

Hu WH, Chan GK, Lou JS, Wu QY, Wang HY, Duan R, Cheng MY, Dong TT, Tsim KW.

Phytomedicine. 2018 Mar 15;42:135-143. doi: 10.1016/j.phymed.2018.03.029. Epub 2018 Mar 17.


Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus.

Zhu Y, Chao C, Duan X, Cheng X, Liu P, Su S, Duan J, Dong TT, Tsim KW.

Sci Rep. 2017 May 3;7(1):1467. doi: 10.1038/s41598-017-01561-2.


Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing.

Lam KY, Ku CF, Wang HY, Chan GK, Yao P, Lin HQ, Dong TT, Zhang HJ, Tsim KW.

Chin Med. 2016 Sep 26;11:41. eCollection 2016.


Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron.

Zhu Y, Duan X, Cheng X, Cheng X, Li X, Zhang L, Liu P, Su S, Duan JA, Dong TT, Tsim KW, Huang F.

J Ethnopharmacol. 2016 Dec 4;193:423-432. doi: 10.1016/j.jep.2016.09.037. Epub 2016 Sep 20.


Kai-Xin-San, a traditional Chinese medicine formula, induces neuronal differentiation of cultured PC12 cells: Modulating neurotransmitter regulation enzymes and potentiating NGF inducing neurite outgrowth.

Zhu Y, Duan X, Huang F, Cheng X, Zhang L, Liu P, Shulan S, Duan JA, Dong TT, Tsim KW.

J Ethnopharmacol. 2016 Dec 4;193:272-282. doi: 10.1016/j.jep.2016.08.013. Epub 2016 Aug 12.


Indication of nerve growth factor binding components from herbal extracts by HerboChip: a platform for drug screening on a chip.

Lee PS, Zhang LM, Yan AL, Lam KY, Dong TT, Lin H, Chan GK, Tsim KW.

Chin Med. 2016 Jul 23;11:34. doi: 10.1186/s13020-016-0107-8. eCollection 2016.


Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.

Hu SQ, Cui W, Mak SH, Choi CL, Hu YJ, Li G, Tsim KW, Pang YP, Han YF.

CNS Neurosci Ther. 2015 Jun;21(6):520-9. doi: 10.1111/cns.12401. Epub 2015 Apr 28.

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