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Items: 1 to 20 of 152

1.

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.

Aitken L, Benek O, McKelvie BE, Hughes RE, Hroch L, Schmidt M, Major LL, Vinklarova L, Kuca K, Smith TK, Musilek K, Gunn-Moore FJ.

Molecules. 2019 Jul 29;24(15). pii: E2757. doi: 10.3390/molecules24152757.

2.

Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity.

Salajkova S, Sramek M, Malinak D, Havel F, Musilek K, Benkova M, Soukup O, Vasicova P, Prchal L, Dolezal R, Hodny Z, Bartek J, Zarska M, Kuca K.

J Biophotonics. 2019 Jul 12:e201900024. doi: 10.1002/jbio.201900024. [Epub ahead of print]

PMID:
31298802
3.

Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models.

Iqbal A, Malik S, Nurulain SM, Musilek K, Kuca K, Kalasz H, Fatmi MQ.

Chem Biol Interact. 2019 Sep 1;310:108735. doi: 10.1016/j.cbi.2019.108735. Epub 2019 Jul 2.

PMID:
31276662
4.

Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation.

Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Andjelkovic M, Djordjevic AB, Antonijevic B.

Chem Biol Interact. 2019 Aug 1;308:385-391. doi: 10.1016/j.cbi.2019.05.034. Epub 2019 May 26. No abstract available.

PMID:
31141677
5.

Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase.

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, França TCC.

Chem Biol Interact. 2019 Aug 1;308:113-119. doi: 10.1016/j.cbi.2019.05.022. Epub 2019 May 14.

PMID:
31100275
6.

Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.

Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z.

Chem Biol Interact. 2019 Jul 1;307:16-20. doi: 10.1016/j.cbi.2019.04.020. Epub 2019 Apr 18.

PMID:
31004594
7.

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Pachón-Angona I, Refouvelet B, Andrýs R, Martin H, Luzet V, Iriepa I, Moraleda I, Diez-Iriepa D, Oset-Gasque MJ, Marco-Contelles J, Musilek K, Ismaili L.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):479-489. doi: 10.1080/14756366.2018.1545766.

8.

Oxime K203: a drug candidate for the treatment of tabun intoxication.

Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J.

Arch Toxicol. 2019 Mar;93(3):673-691. doi: 10.1007/s00204-018-2377-7. Epub 2018 Dec 18.

PMID:
30564897
9.

Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.

Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K.

J Med Chem. 2018 Dec 13;61(23):10753-10766. doi: 10.1021/acs.jmedchem.8b01398. Epub 2018 Nov 20.

PMID:
30383374
10.

Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS).

de Almeida JSFD, Dolezal R, Krejcar O, Kuca K, Musilek K, Jun D, França TCC.

Toxins (Basel). 2018 Sep 25;10(10). pii: E389. doi: 10.3390/toxins10100389.

11.

QSAR Study of N-Myristoyltransferase Inhibitors of Antimalarial Agents.

Santos-Garcia L, de Mecenas Filho MA, Musilek K, Kuca K, Ramalho TC, da Cunha EFF.

Molecules. 2018 Sep 13;23(9). pii: E2348. doi: 10.3390/molecules23092348.

12.

Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study.

Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K.

Molecules. 2018 Sep 7;23(9). pii: E2291. doi: 10.3390/molecules23092291.

13.

Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes.

Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Curcic M, Miladinovic DC, Bulat Z, Antonijevic B.

Food Chem Toxicol. 2018 Nov;121:224-230. doi: 10.1016/j.fct.2018.08.065. Epub 2018 Sep 1.

PMID:
30176309
14.

Vector Control and Insecticidal Resistance in the African Malaria Mosquito Anopheles gambiae.

Schmidt M, Hrabcova V, Jun D, Kuca K, Musilek K.

Chem Res Toxicol. 2018 Jul 16;31(7):534-547. doi: 10.1021/acs.chemrestox.7b00285. Epub 2018 Jun 15. Review.

PMID:
29847927
15.

Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site of human acetylcholinesterase.

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, França TCC.

J Biomol Struct Dyn. 2019 May;37(8):2041-2048. doi: 10.1080/07391102.2018.1475259. Epub 2018 Nov 2.

PMID:
29749305
16.

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon.

Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, França TCC.

Molecules. 2018 May 7;23(5). pii: E1103. doi: 10.3390/molecules23051103.

17.

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings.

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K.

Drug Des Devel Ther. 2018 Mar 9;12:505-512. doi: 10.2147/DDDT.S133038. eCollection 2018.

18.

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

Benek O, Hroch L, Aitken L, Gunn-Moore F, Vinklarova L, Kuca K, Perez DI, Perez C, Martinez A, Fisar Z, Musilek K.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):665-670. doi: 10.1080/14756366.2018.1445736.

19.

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase.

Kuca K, Musilek K, Jun D, Zdarova-Karasova J, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC, Da Cunha EFF, De Castro AA, Valis M, Ramalho TC.

BMC Pharmacol Toxicol. 2018 Feb 21;19(1):8. doi: 10.1186/s40360-018-0196-3.

20.

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K.

Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657.

PMID:
29332594

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