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Items: 1 to 20 of 451

1.

Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease.

de Oliveira C Brum J, Neto DCF, de Almeida JSFD, Lima JA, Kuca K, França TCC, Figueroa-Villar JD.

Int J Mol Sci. 2019 Aug 14;20(16). pii: E3944. doi: 10.3390/ijms20163944.

2.

Efficacy of methylprednisolone on T-2 toxin-induced cardiotoxicity in vivo: A pathohistological study.

Jaćević V, Wu Q, Nepovimova E, Kuča K.

Environ Toxicol Pharmacol. 2019 Jul 19;71:103221. doi: 10.1016/j.etap.2019.103221. [Epub ahead of print]

PMID:
31365892
3.

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.

Aitken L, Benek O, McKelvie BE, Hughes RE, Hroch L, Schmidt M, Major LL, Vinklarova L, Kuca K, Smith TK, Musilek K, Gunn-Moore FJ.

Molecules. 2019 Jul 29;24(15). pii: E2757. doi: 10.3390/molecules24152757.

4.

Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity.

Salajkova S, Sramek M, Malinak D, Havel F, Musilek K, Benkova M, Soukup O, Vasicova P, Prchal L, Dolezal R, Hodny Z, Bartek J, Zarska M, Kuca K.

J Biophotonics. 2019 Jul 12:e201900024. doi: 10.1002/jbio.201900024. [Epub ahead of print]

PMID:
31298802
5.

Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models.

Iqbal A, Malik S, Nurulain SM, Musilek K, Kuca K, Kalasz H, Fatmi MQ.

Chem Biol Interact. 2019 Sep 1;310:108735. doi: 10.1016/j.cbi.2019.108735. Epub 2019 Jul 2.

PMID:
31276662
6.

MicroRNAs in Alzheimer's Disease: Diagnostic Markers or Therapeutic Agents?

Angelucci F, Cechova K, Valis M, Kuca K, Zhang B, Hort J.

Front Pharmacol. 2019 Jun 18;10:665. doi: 10.3389/fphar.2019.00665. eCollection 2019. Review.

7.

Oximes as pretreatment before acute exposure to paraoxon.

Lorke DE, Nurulain SM, Hasan MY, Kuča K, Petroianu GA.

J Appl Toxicol. 2019 Jul 2. doi: 10.1002/jat.3835. [Epub ahead of print]

PMID:
31264735
8.

Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats.

Zdarova Karasova J, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K.

Drug Chem Toxicol. 2019 Jul 1:1-8. doi: 10.1080/01480545.2019.1566350. [Epub ahead of print]

PMID:
31257938
9.

Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects.

Polisel DA, de Castro AA, Mancini DT, da Cunha EFF, França TCC, Ramalho TC, Kuca K.

Chem Biol Interact. 2019 Aug 25;309:108671. doi: 10.1016/j.cbi.2019.05.037. Epub 2019 Jun 15.

PMID:
31207225
10.

Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate.

Cavalcante SFA, Kitagawa DAS, Rodrigues RB, Bernardo LB, da Silva TN, Dos Santos WV, Correa ABA, de Almeida JSFD, França TCC, Kuča K, Simas ABC.

Chem Biol Interact. 2019 Aug 25;309:108682. doi: 10.1016/j.cbi.2019.05.048. Epub 2019 Jun 1.

PMID:
31163137
11.

Venous Thromboembolism as an Adverse Effect During Treatment With Olanzapine: A Case Series.

Masopust J, Bazantova V, Kuca K, Klimova B, Valis M.

Front Psychiatry. 2019 May 15;10:330. doi: 10.3389/fpsyt.2019.00330. eCollection 2019.

12.

Interspecies and intergender differences in acute toxicity of K-oximes drug candidates.

Jaćević V, Nepovimova E, Kuča K.

Chem Biol Interact. 2019 Aug 1;308:312-316. doi: 10.1016/j.cbi.2019.05.035. Epub 2019 May 31.

PMID:
31153983
13.

Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation.

Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Andjelkovic M, Djordjevic AB, Antonijevic B.

Chem Biol Interact. 2019 Aug 1;308:385-391. doi: 10.1016/j.cbi.2019.05.034. Epub 2019 May 26. No abstract available.

PMID:
31141677
14.

Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths.

da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Costa França TC.

Chem Biol Interact. 2019 Jul 1;307:195-205. doi: 10.1016/j.cbi.2019.05.019. Epub 2019 May 21.

PMID:
31121152
15.

Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase.

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, França TCC.

Chem Biol Interact. 2019 Aug 1;308:113-119. doi: 10.1016/j.cbi.2019.05.022. Epub 2019 May 14.

PMID:
31100275
16.

Interaction of synthesized nitrogen enriched graphene quantum dots with novel anti-Alzheimer's drugs: spectroscopic insights.

Sharma S, Singh N, Nepovimova E, Korabecny J, Kuca K, Satnami ML, Ghosh KK.

J Biomol Struct Dyn. 2019 May 27:1-16. doi: 10.1080/07391102.2019.1619625. [Epub ahead of print]

PMID:
31096863
17.

Vascular Cognitive Impairment: Information from Animal Models on the Pathogenic Mechanisms of Cognitive Deficits.

Hort J, Vališ M, Kuča K, Angelucci F.

Int J Mol Sci. 2019 May 15;20(10). pii: E2405. doi: 10.3390/ijms20102405. Review.

18.

Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.

da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Celmar Costa França T.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1018-1029. doi: 10.1080/14756366.2019.1609953.

19.

Chyawanprash: A Traditional Indian Bioactive Health Supplement.

Sharma R, Martins N, Kuca K, Chaudhary A, Kabra A, Rao MM, Prajapati PK.

Biomolecules. 2019 Apr 26;9(5). pii: E161. doi: 10.3390/biom9050161. Review.

20.

Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments.

Sales TA, Prandi IG, Castro AA, Leal DHS, Cunha EFFD, Kuca K, Ramalho TC.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1829. doi: 10.3390/ijms20081829. Review.

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