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Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study.

Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian W, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D; TEDDY Study Group.

Gut. 2019 Nov 19. pii: gutjnl-2019-319809. doi: 10.1136/gutjnl-2019-319809. [Epub ahead of print]


Metabolite-related dietary patterns and the development of islet autoimmunity.

Johnson RK, Vanderlinden L, DeFelice BC, Kechris K, Uusitalo U, Fiehn O, Sontag M, Crume T, Beyerlein A, Lernmark Å, Toppari J, Ziegler AG, She JX, Hagopian W, Rewers M, Akolkar B, Krischer J, Virtanen SM, Norris JM; TEDDY Study Group.

Sci Rep. 2019 Oct 15;9(1):14819. doi: 10.1038/s41598-019-51251-4.


European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020.

Husby S, Koletzko S, Korponay-Szabó I, Kurppa K, Mearin ML, Ribes-Koninckx C, Shamir R, Troncone R, Auricchio R, Castillejo G, Christensen R, Dolinsek J, Gillett P, Hróbjartsson A, Koltai T, Maki M, Nielsen SM, Popp A, Bucharest, Størdal K, Werkstetter K, Wessels M.

J Pediatr Gastroenterol Nutr. 2019 Oct 17. doi: 10.1097/MPG.0000000000002497. [Epub ahead of print]


The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children.

Frank NM, Lynch KF, Uusitalo U, Yang J, Lönnrot M, Virtanen SM, Hyöty H, Norris JM; TEDDY Study Group.

BMC Pediatr. 2019 Sep 18;19(1):339. doi: 10.1186/s12887-019-1693-2.


Further Support for Psychological Symptoms in Pediatric Celiac Disease.

Smith LB, Kurppa K, Agardh D.

Pediatrics. 2019 Oct;144(4). pii: e20191683. doi: 10.1542/peds.2019-1683. Epub 2019 Sep 6. No abstract available.


Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?

Popp A, Kivelä L, Fuchs V, Kurppa K.

Gastroenterol Res Pract. 2019 Aug 6;2019:2916024. doi: 10.1155/2019/2916024. eCollection 2019. Review.


Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk.

Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, Uusitalo U, Yang J, Koletzko S, Liu E, Kurppa K, Bingley PJ, Toppari J, Ziegler AG, She JX, Hagopian WA, Rewers M, Akolkar B, Krischer JP, Virtanen SM, Norris JM, Agardh D; TEDDY Study Group.

JAMA. 2019 Aug 13;322(6):514-523. doi: 10.1001/jama.2019.10329.


Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk.

Uusitalo U, Andren Aronsson C, Liu X, Kurppa K, Yang J, Liu E, Skidmore J, Winkler C, Rewers MJ, Hagopian WA, She JX, Toppari J, Ziegler AG, Akolkar B, Norris JM, Virtanen SM, Krischer JP, Agardh D; TEDDY Study Group.

Nutrients. 2019 Aug 2;11(8). pii: E1790. doi: 10.3390/nu11081790.


Daily Life Restrictions are Common and Associated with Health Concerns and Dietary Challenges in Adult Celiac Disease Patients Diagnosed in Childhood.

Leinonen H, Kivelä L, Lähdeaho ML, Huhtala H, Kaukinen K, Kurppa K.

Nutrients. 2019 Jul 25;11(8). pii: E1718. doi: 10.3390/nu11081718.


The use of abdominal imaging studies in children visiting emergency department was variable and unsystematic.

Lammi M, Vuolle S, Kiekara T, Kurppa K, Pauniaho SL.

Acta Paediatr. 2019 Nov;108(11):2089-2094. doi: 10.1111/apa.14868. Epub 2019 Jun 24.


Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report.

Krischer JP, Liu X, Vehik K, Akolkar B, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Lernmark Å; TEDDY Study Group.

Diabetes Care. 2019 Jun;42(6):1051-1060. doi: 10.2337/dc18-2282. Epub 2019 Apr 9.


Letter: the end of duodenal biopsies in coeliac disease? Authors' reply.

Kurppa K, Fuchs V, Kaukinen K.

Aliment Pharmacol Ther. 2019 Apr;49(8):1112. doi: 10.1111/apt.15220. No abstract available.


The Phenotype of Celiac Disease Has Low Concordance between Siblings, Despite a Similar Distribution of HLA Haplotypes.

Kauma S, Kaukinen K, Huhtala H, Kivelä L, Pekki H, Salmi T, Saavalainen P, Lindfors K, Kurppa K.

Nutrients. 2019 Feb 25;11(2). pii: E479. doi: 10.3390/nu11020479.


Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group; Teddy Study Group.

Diabetes. 2019 Apr;68(4):847-857. doi: 10.2337/db18-0882. Epub 2019 Jan 17.


Coeliac disease.

Lindfors K, Ciacci C, Kurppa K, Lundin KEA, Makharia GK, Mearin ML, Murray JA, Verdu EF, Kaukinen K.

Nat Rev Dis Primers. 2019 Jan 10;5(1):3. doi: 10.1038/s41572-018-0054-z. Review.


Serology-based criteria for adult coeliac disease have excellent accuracy across the range of pre-test probabilities.

Fuchs V, Kurppa K, Huhtala H, Laurila K, Mäki M, Collin P, Salmi T, Luostarinen L, Saavalainen P, Kaukinen K.

Aliment Pharmacol Ther. 2019 Feb;49(3):277-284. doi: 10.1111/apt.15109. Epub 2018 Dec 27.


Small-intestinal TG2-specific plasma cells at different stages of coeliac disease.

Hietikko M, Koskinen O, Kurppa K, Laurila K, Saavalainen P, Salmi T, Ilus T, Huhtala H, Kaukinen K, Lindfors K.

BMC Immunol. 2018 Dec 6;19(1):36. doi: 10.1186/s12865-018-0275-7.


The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Rewers M, Hyöty H, Lernmark Å, Hagopian W, She JX, Schatz D, Ziegler AG, Toppari J, Akolkar B, Krischer J; TEDDY Study Group.

Curr Diab Rep. 2018 Oct 23;18(12):136. doi: 10.1007/s11892-018-1113-2. Review.


Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children.

Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P; TEDDY Study Group.

Diabetes. 2019 Jan;68(1):119-130. doi: 10.2337/db18-0594. Epub 2018 Oct 10.


Microbial Biomarkers in Patients with Nonresponsive Celiac Disease.

Viitasalo L, Kurppa K, Ashorn M, Saavalainen P, Huhtala H, Ashorn S, Mäki M, Ilus T, Kaukinen K, Iltanen S.

Dig Dis Sci. 2018 Dec;63(12):3434-3441. doi: 10.1007/s10620-018-5285-z. Epub 2018 Sep 20.


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