Format

Send to

Choose Destination
Molecules. 2018 May 15;23(5). pii: E1185. doi: 10.3390/molecules23051185.

Study on the Polar Extracts of Dendrobium nobile, D. officinale, D. loddigesii, and Flickingeria fimbriata: Metabolite Identification, Content Evaluation, and Bioactivity Assay.

Author information

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. chenhp25@mail2.sysu.edu.cn.
2
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lixw28@mail2.sysu.edu.cn.
3
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. xuyl7@mail2.sysu.edu.cn.
4
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lokk@mail2.sysu.edu.cn.
5
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. shirleyzheng1126@gmail.com.
6
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lsshhy@mail.sysu.edu.cn.
7
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wjun@mail.sysu.edu.cn.
8
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.

Abstract

The polar extract of the Dendrobium species or F. fimbriata (a substitute of Dendrobium), between the fat-soluble extract and polysaccharide has barely been researched. This report worked on the qualitative and quantitative studies of polar extracts from D. nobile, D. officinale, D. loddigesii, and F. fimbriata. Eight water-soluble metabolites containing a new diglucoside, flifimdioside A (1), and a rare imidazolium-type alkaloid, anosmine (4), were identified using chromatography as well as spectroscopic techniques. Their contents in the four herbs were high, approximately 0.9⁻3.7 mg/g based on the analysis of quantitative nuclear magnetic resonance (qNMR) spectroscopy. Biological activity evaluation showed that the polar extract of F. fimbriata or its pure component had good antioxidant and neuroprotective activity; compounds 14 and shihunine (8) showed weak α-glucosidase inhibitory activity; 4 and 8 had weak anti-inflammatory activity. Under trial conditions, all samples had no cytotoxic activity.

KEYWORDS:

Dendrobium; Flickingeria fimbriata; antioxygenation; neuroprotection; qNMR; α-glucosidase inhibition

PMID:
29762539
DOI:
10.3390/molecules23051185
Free full text

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI)
Loading ...
Support Center