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Items: 1 to 20 of 210

1.

p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization.

Peng J, Li J, Huang J, Xu P, Huang H, Liu Y, Yu L, Yang Y, Zhou B, Jiang H, Chen K, Dang Y, Zhang Y, Luo C, Li G.

Theranostics. 2019 Oct 22;9(26):8344-8361. doi: 10.7150/thno.30707. eCollection 2019.

2.

Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria.

Zhang D, Shi Y, Li J, Ruan D, Jia Q, Zhu W, Chen K, Li Y, Wang R.

Molecules. 2019 Nov 7;24(22). pii: E4033. doi: 10.3390/molecules24224033.

3.

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.

Lu W, Wang J, Li Y, Tao H, Xiong H, Lian F, Gao J, Ma H, Lu T, Zhang D, Ye X, Ding H, Yue L, Zhang Y, Tang H, Zhang N, Yang Y, Jiang H, Chen K, Zhou B, Luo C.

Eur J Med Chem. 2019 Dec 15;184:111767. doi: 10.1016/j.ejmech.2019.111767. Epub 2019 Oct 9.

PMID:
31622854
4.

A review of the ethnopharmacology, phytochemistry, pharmacology, and quality control of Scutellaria barbata D. Don.

Wang L, Chen W, Li M, Zhang F, Chen K, Chen W.

J Ethnopharmacol. 2019 Sep 29:112260. doi: 10.1016/j.jep.2019.112260. [Epub ahead of print] Review.

PMID:
31577937
5.

Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods.

Wang D, Cui C, Ding X, Xiong Z, Zheng M, Luo X, Jiang H, Chen K.

Front Pharmacol. 2019 Aug 22;10:924. doi: 10.3389/fphar.2019.00924. eCollection 2019.

6.

Alkaloid Enantiomers from the Roots of Isatis indigotica.

Zhang D, Shi Y, Xu R, Du K, Guo F, Chen K, Li Y, Wang R.

Molecules. 2019 Aug 29;24(17). pii: E3140. doi: 10.3390/molecules24173140.

7.

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.

Chen D, Lu T, Yan Z, Lu W, Zhou F, Lyu X, Xu B, Jiang H, Chen K, Luo C, Zhao Y.

Eur J Med Chem. 2019 Nov 15;182:111633. doi: 10.1016/j.ejmech.2019.111633. Epub 2019 Aug 21.

PMID:
31461688
8.

Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism.

Xiong Z, Wang D, Liu X, Zhong F, Wan X, Li X, Li Z, Luo X, Chen K, Jiang H, Zheng M.

J Med Chem. 2019 Aug 27. doi: 10.1021/acs.jmedchem.9b00959. [Epub ahead of print]

PMID:
31408336
9.

Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia-mediated ERK1/2-NF-κB signaling pathway.

Zhang T, Ouyang H, Mei X, Lu B, Yu Z, Chen K, Wang Z, Ji L.

FASEB J. 2019 Nov;33(11):11776-11790. doi: 10.1096/fj.201802614RRR. Epub 2019 Jul 31.

PMID:
31365278
10.

Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation.

Li X, Li Z, Wu X, Xiong Z, Yang T, Fu Z, Liu X, Tan X, Zhong F, Wan X, Wang D, Ding X, Yang R, Hou H, Li C, Liu H, Chen K, Jiang H, Zheng M.

J Med Chem. 2019 Aug 15. doi: 10.1021/acs.jmedchem.9b00855. [Epub ahead of print]

PMID:
31364850
11.

Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria.

Zhang D, Shi Y, Shi S, Wu X, Zhang L, Chen K, Li Y, Wang R.

Nat Prod Res. 2019 Jul 22:1-7. doi: 10.1080/14786419.2019.1644632. [Epub ahead of print]

PMID:
31328551
12.

D3Pockets: A Method and Web Server for Systematic Analysis of Protein Pocket Dynamics.

Chen Z, Zhang X, Peng C, Wang J, Xu Z, Chen K, Shi J, Zhu W.

J Chem Inf Model. 2019 Aug 26;59(8):3353-3358. doi: 10.1021/acs.jcim.9b00332. Epub 2019 Jul 16.

PMID:
31265282
13.

KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules.

Li Z, Li X, Liu X, Fu Z, Xiong Z, Wu X, Tan X, Zhao J, Zhong F, Wan X, Luo X, Chen K, Jiang H, Zheng M.

Bioinformatics. 2019 Jun 22. pii: btz519. doi: 10.1093/bioinformatics/btz519. [Epub ahead of print]

PMID:
31228181
14.

Indole alkaloid glycosides from Isatis tinctoria roots.

Zhang D, Du K, Zhao Y, Shi S, Wu Y, Jia Q, Chen K, Li Y, Wang R.

Nat Prod Res. 2019 Jun 7:1-7. doi: 10.1080/14786419.2019.1624960. [Epub ahead of print]

PMID:
31174427
15.

Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production.

Zhang D, Li J, Ruan D, Chen Z, Zhu W, Shi Y, Chen K, Li Y, Wang R.

Fitoterapia. 2019 Sep;137:104189. doi: 10.1016/j.fitote.2019.104189. Epub 2019 May 31.

PMID:
31158429
16.

The dynamic conformational landscape of the protein methyltransferase SETD8.

Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H, Zou H, Wang J, Fan S, Blum G, Pittella-Silva F, Beauchamp KA, Tempel W, Jiang H, Chen K, Skene RJ, Zheng YG, Brown PJ, Jin J, Luo C, Chodera JD, Luo M.

Elife. 2019 May 13;8. pii: e45403. doi: 10.7554/eLife.45403.

17.

Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.

Yang T, Liu T, Gan J, Yu K, Chen K, Xue W, Lan L, Yang S, Yang CG.

ACS Infect Dis. 2019 Jun 14;5(6):841-850. doi: 10.1021/acsinfecdis.8b00316. Epub 2019 Mar 25.

PMID:
30868877
18.

Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1.

Xu H, Tang Z, Zuo Y, Xiong F, Chen K, Jiang H, Luo C, Zhang H.

J Biomol Struct Dyn. 2019 Mar 7:1-10. doi: 10.1080/07391102.2019.1591303. [Epub ahead of print]

PMID:
30843765
19.

Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening.

Zhang D, Han J, Lu W, Lian F, Wang J, Lu T, Tao H, Xiao S, Zhang F, Liu YC, Liu R, Zhang N, Jiang H, Chen K, Zhao C, Luo C.

Bioorg Chem. 2019 May;86:494-500. doi: 10.1016/j.bioorg.2019.01.035. Epub 2019 Jan 28.

PMID:
30780018
20.

The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening.

Ye X, Zhang R, Lian F, Zhang W, Lu W, Han J, Zhang N, Jin J, Luo C, Chen K, Ye F, Ding H.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. doi: 10.1016/j.bmcl.2018.12.035. Epub 2018 Dec 17.

PMID:
30626558

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