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Items: 1 to 20 of 224


Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients.

Kiamehr M, Klettner A, Richert E, Koskela A, Koistinen A, Skottman H, Kaarniranta K, Aalto-Setälä K, Juuti-Uusitalo K.

Int J Mol Sci. 2019 Aug 1;20(15). pii: E3773. doi: 10.3390/ijms20153773.


Can vitamin D protect against age-related macular degeneration or slow its progression?

Kaarniranta K, Pawlowska E, Szczepanska J, Jablkowska A, Błasiak J.

Acta Biochim Pol. 2019 Jun 18;66(2):147-158. doi: 10.18388/abp.2018_2810.


AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging.

Salminen A, Kauppinen A, Kaarniranta K.

J Mol Med (Berl). 2019 Aug;97(8):1049-1064. doi: 10.1007/s00109-019-01795-9. Epub 2019 May 25. Review.


Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD).

Kaarniranta K, Pawlowska E, Szczepanska J, Jablkowska A, Blasiak J.

Int J Mol Sci. 2019 May 14;20(10). pii: E2374. doi: 10.3390/ijms20102374. Review.


Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond.

Pawlowska E, Szczepanska J, Koskela A, Kaarniranta K, Blasiak J.

Oxid Med Cell Longev. 2019 Mar 24;2019:9682318. doi: 10.1155/2019/9682318. eCollection 2019. Review.


Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy.

Hytti M, Korhonen E, Hyttinen JMT, Roehrich H, Kaarniranta K, Ferrington DA, Kauppinen A.

Oxid Med Cell Longev. 2019 Mar 17;2019:1583656. doi: 10.1155/2019/1583656. eCollection 2019.


Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study.

Bourne RRA, Kaarniranta K, Lorenz K, Traverso CE, Vuorinen J, Ropo A.

BMJ Open. 2019 Apr 2;9(4):e024129. doi: 10.1136/bmjopen-2018-024129.


Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation.

Szatmári-Tóth M, Ilmarinen T, Mikhailova A, Skottman H, Kauppinen A, Kaarniranta K, Kristóf E, Lytvynchuk L, Veréb Z, Fésüs L, Petrovski G.

Int J Mol Sci. 2019 Feb 20;20(4). pii: E926. doi: 10.3390/ijms20040926.


Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency.

Salminen A, Kaarniranta K, Kauppinen A.

Cell Mol Life Sci. 2019 May;76(10):1901-1918. doi: 10.1007/s00018-019-03048-x. Epub 2019 Feb 20. Review.


SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1β-stimulated human retinal pigment epithelial cells.

Korhonen E, Piippo N, Hytti M, Hyttinen JMT, Kaarniranta K, Kauppinen A.

Cytokine. 2019 Apr;116:70-77. doi: 10.1016/j.cyto.2018.12.015. Epub 2019 Jan 24.


The first ophthalmic Choosing Wisely recommendations in Finland for glaucoma and wet age-related macular degeneration.

Tuuminen R, Sipilä R, Komulainen J, Saarela V, Kaarniranta K, Tuulonen A.

Acta Ophthalmol. 2019 Aug;97(5):e808-e810. doi: 10.1111/aos.14031. Epub 2019 Jan 18. No abstract available.


Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration.

Blasiak J, Pawlowska E, Szczepanska J, Kaarniranta K.

Int J Mol Sci. 2019 Jan 8;20(1). pii: E210. doi: 10.3390/ijms20010210. Review.


Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG.

J Mol Med (Berl). 2019 Mar;97(3):341-354. doi: 10.1007/s00109-018-01734-0. Epub 2019 Jan 7.


Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.

Ilmarinen T, Thieltges F, Hongisto H, Juuti-Uusitalo K, Koistinen A, Kaarniranta K, Brinken R, Braun N, Holz FG, Skottman H, Stanzel BV.

Acta Ophthalmol. 2019 Aug;97(5):e688-e699. doi: 10.1111/aos.14004. Epub 2018 Dec 28.


Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K.

Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.


The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process.

Salminen A, Kaarniranta K, Kauppinen A.

Ageing Res Rev. 2018 Dec;48:1-10. doi: 10.1016/j.arr.2018.09.001. Epub 2018 Sep 21. Review.


Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy.

Piippo N, Korhonen E, Hytti M, Kinnunen K, Kaarniranta K, Kauppinen A.

Cell Physiol Biochem. 2018;49(1):359-367. doi: 10.1159/000492886. Epub 2018 Aug 23.


PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis.

Kaarniranta K, Kajdanek J, Morawiec J, Pawlowska E, Blasiak J.

Int J Mol Sci. 2018 Aug 7;19(8). pii: E2317. doi: 10.3390/ijms19082317. Review.


Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage.

Abu Khamidakh AE, Rodriguez-Martinez A, Kaarniranta K, Kallioniemi A, Skottman H, Hyttinen J, Juuti-Uusitalo K.

Biomed Eng Online. 2018 Jul 31;17(1):102. doi: 10.1186/s12938-018-0535-z.


Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration.

Kaarniranta K, Koskela A, Felszeghy S, Kivinen N, Salminen A, Kauppinen A.

Biochimie. 2019 Apr;159:49-54. doi: 10.1016/j.biochi.2018.07.010. Epub 2018 Jul 18. Review.


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