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Items: 1 to 20 of 208

1.

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy.

Piippo N, Korhonen E, Hytti M, Kinnunen K, Kaarniranta K, Kauppinen A.

Cell Physiol Biochem. 2018;49(1):359-367. doi: 10.1159/000492886. Epub 2018 Aug 23.

2.

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis.

Kaarniranta K, Kajdanek J, Morawiec J, Pawlowska E, Blasiak J.

Int J Mol Sci. 2018 Aug 7;19(8). pii: E2317. doi: 10.3390/ijms19082317. Review.

3.

Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage.

Abu Khamidakh AE, Rodriguez-Martinez A, Kaarniranta K, Kallioniemi A, Skottman H, Hyttinen J, Juuti-Uusitalo K.

Biomed Eng Online. 2018 Jul 31;17(1):102. doi: 10.1186/s12938-018-0535-z.

4.

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration.

Kaarniranta K, Koskela A, Felszeghy S, Kivinen N, Salminen A, Kauppinen A.

Biochimie. 2018 Jul 18. pii: S0300-9084(18)30205-0. doi: 10.1016/j.biochi.2018.07.010. [Epub ahead of print]

PMID:
30031036
5.

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence.

Salminen A, Kauppinen A, Kaarniranta K.

Biogerontology. 2018 Oct;19(5):325-339. doi: 10.1007/s10522-018-9762-8. Epub 2018 Jun 29. Review.

PMID:
29959657
6.

Molecular Mechanisms Underlying Age-Related Ocular Diseases.

Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA.

Oxid Med Cell Longev. 2018 May 21;2018:8476164. doi: 10.1155/2018/8476164. eCollection 2018. No abstract available.

7.

Nrf2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice.

Ruotsalainen AK, Lappalainen JP, Heiskanen E, Merentie M, Sihvola V, Näpänkangas J, Lottonen-Raikaslehto L, Kansanen E, Adinolfi S, Kaarniranta K, Ylä-Herttuala S, Jauhiainen M, Pirinen E, Levonen AL.

Cardiovasc Res. 2018 Jun 18. doi: 10.1093/cvr/cvy143. [Epub ahead of print]

PMID:
29917052
8.

Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.

Salminen A, Kaarniranta K, Kauppinen A.

Int Immunopharmacol. 2018 Aug;61:231-240. doi: 10.1016/j.intimp.2018.06.005. Epub 2018 Jun 9. Review.

PMID:
29894862
9.

The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease.

Salminen A, Kaarniranta K, Kauppinen A.

Cell Mol Life Sci. 2018 Sep;75(17):3099-3120. doi: 10.1007/s00018-018-2844-6. Epub 2018 May 19. Review.

PMID:
29779041
10.

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Hyttinen JMT, Viiri J, Kaarniranta K, Błasiak J.

Cell Mol Life Sci. 2018 Aug;75(16):2991-3008. doi: 10.1007/s00018-018-2843-7. Epub 2018 May 18. Review.

PMID:
29777261
11.

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome.

Piippo N, Korhonen E, Hytti M, Skottman H, Kinnunen K, Josifovska N, Petrovski G, Kaarniranta K, Kauppinen A.

Sci Rep. 2018 Apr 30;8(1):6720. doi: 10.1038/s41598-018-25123-2.

12.

Mechanistical retinal drug targets and challenges.

Kaarniranta K, Xu H, Kauppinen A.

Adv Drug Deliv Rev. 2018 Feb 15;126:177-184. doi: 10.1016/j.addr.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698626
13.

Tear film proteome in age-related macular degeneration.

Winiarczyk M, Kaarniranta K, Winiarczyk S, Adaszek Ł, Winiarczyk D, Mackiewicz J.

Graefes Arch Clin Exp Ophthalmol. 2018 Jun;256(6):1127-1139. doi: 10.1007/s00417-018-3984-y. Epub 2018 Apr 25.

14.

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways.

Marchesi N, Thongon N, Pascale A, Provenzani A, Koskela A, Korhonen E, Smedowski A, Govoni S, Kauppinen A, Kaarniranta K, Amadio M.

Oxid Med Cell Longev. 2018 Feb 8;2018:4956080. doi: 10.1155/2018/4956080. eCollection 2018.

15.

[Pathogenesis of age-related macular degeneration - dialogue between autophagy and inflammasomes] .

Kivinen N, Koskela A, Kauppinen A, Kaarniranta K.

Duodecim. 2017;133(7):641-6. Review. Finnish.

PMID:
29243450
16.

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

Blasiak J, Piechota M, Pawlowska E, Szatkowska M, Sikora E, Kaarniranta K.

Oxid Med Cell Longev. 2017;2017:5293258. doi: 10.1155/2017/5293258. Epub 2017 Nov 1. Review.

17.

Individual benefits of enoxaparin treatment in branch vein occlusion.

Dragoni F, Kaarniranta K.

Graefes Arch Clin Exp Ophthalmol. 2018 May;256(5):1031-1033. doi: 10.1007/s00417-017-3854-z. Epub 2017 Dec 1. No abstract available.

PMID:
29192333
18.

The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration.

Tuuminen R, Tuulonen A, Kaarniranta K; Expert Panel co-ordinated by the Finnish Medical Society Duodecim, the Finnish Ophthalmological Society and all Departments of Ophthalmology of the University and Central Hospitals in Finland.

Acta Ophthalmol. 2017 Nov;95(7):649-650. doi: 10.1111/aos.13341. No abstract available.

PMID:
29110437
19.

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.

Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M.

Biochim Biophys Acta. 2018 Jan;1864(1):296-306. doi: 10.1016/j.bbadis.2017.10.030. Epub 2017 Oct 28.

PMID:
29107807
20.

Outcome of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in real-life setting.

Kataja M, Hujanen P, Huhtala H, Kaarniranta K, Tuulonen A, Uusitalo-Jarvinen H.

Br J Ophthalmol. 2018 Jul;102(7):959-965. doi: 10.1136/bjophthalmol-2017-311055. Epub 2017 Oct 26.

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