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Items: 1 to 20 of 90


Pharmacology, pharmacokinetics and tissue disposition of zwitterionic hydoxyiminoacetamido alkylamines as reactivating antidotes for organophosphate exposure.

Sit R, Kovarik Z, Macek-Hrvat N, Zunec S, Green C, Fokin V, Sharpless KB, Radic' Z, Taylor P.

J Pharmacol Exp Ther. 2018 Sep 6. pii: jpet.118.249383. doi: 10.1124/jpet.118.249383. [Epub ahead of print]


Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.

Gahtory D, Sen R, Pujari S, Li S, Zheng Q, Moses JE, Sharpless KB, Zuilhof H.

Chemistry. 2018 Jul 20;24(41):10550-10556. doi: 10.1002/chem.201802356. Epub 2018 Jun 27.


SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.

Liu Z, Li J, Li S, Li G, Sharpless KB, Wu P.

J Am Chem Soc. 2018 Feb 28;140(8):2919-2925. doi: 10.1021/jacs.7b12788. Epub 2018 Feb 16.


SuFEx Chemistry of Thionyl Tetrafluoride (SOF4 ) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates.

Gao B, Li S, Wu P, Moses JE, Sharpless KB.

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1939-1943. doi: 10.1002/anie.201712145. Epub 2018 Jan 16.


A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an "F-SO2 +" Donor of Unprecedented Reactivity, Selectivity, and Scope.

Guo T, Meng G, Zhan X, Yang Q, Ma T, Xu L, Sharpless KB, Dong J.

Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2605-2610. doi: 10.1002/anie.201712429. Epub 2018 Jan 25.


"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW.

J Am Chem Soc. 2018 Jan 10;140(1):200-210. doi: 10.1021/jacs.7b08366. Epub 2017 Dec 21.


Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.

Gao B, Zhang L, Zheng Q, Zhou F, Klivansky LM, Lu J, Liu Y, Dong J, Wu P, Sharpless KB.

Nat Chem. 2017 Nov;9(11):1083-1088. doi: 10.1038/nchem.2796. Epub 2017 Jun 19.


SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts.

Wang H, Zhou F, Ren G, Zheng Q, Chen H, Gao B, Klivansky L, Liu Y, Wu B, Xu Q, Lu J, Sharpless KB, Wu P.

Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11203-11208. doi: 10.1002/anie.201701160. Epub 2017 May 18.


Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.

Kim WJ, Korthals KA, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02397-16. doi: 10.1128/AAC.02397-16. Print 2017 Jun.


Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.

Zha GF, Zheng Q, Leng J, Wu P, Qin HL, Sharpless KB.

Angew Chem Int Ed Engl. 2017 Apr 18;56(17):4849-4852. doi: 10.1002/anie.201701162. Epub 2017 Mar 29.


Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub.

Li S, Wu P, Moses JE, Sharpless KB.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2903-2908. doi: 10.1002/anie.201611048. Epub 2017 Feb 6.


Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.

Zheng Q, Dong J, Sharpless KB.

J Org Chem. 2016 Nov 18;81(22):11360-11362. Epub 2016 Nov 3.


A Heck-Matsuda Process for the Synthesis of ╬▓-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.

Qin HL, Zheng Q, Bare GA, Wu P, Sharpless KB.

Angew Chem Int Ed Engl. 2016 Nov 2;55(45):14155-14158. doi: 10.1002/anie.201608807. Epub 2016 Oct 10.


Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE.

Silverman SM, Moses JE, Sharpless KB.

Chemistry. 2017 Jan 1;23(1):79-83. doi: 10.1002/chem.201604765. Epub 2016 Nov 11.


Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW.

J Am Chem Soc. 2016 Jun 15;138(23):7353-64. doi: 10.1021/jacs.6b02960. Epub 2016 Jun 2.


Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates.

Zhang E, Tang J, Li S, Wu P, Moses JE, Sharpless KB.

Chemistry. 2016 Apr 11;22(16):5692-7. doi: 10.1002/chem.201600167. Epub 2016 Mar 15.


Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.

Bourne Y, Sharpless KB, Taylor P, Marchot P.

J Am Chem Soc. 2016 Feb 10;138(5):1611-21. doi: 10.1021/jacs.5b11384. Epub 2016 Jan 28.


Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy.

Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, Wu P, Sharpless KB, Kelly JW.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1835-8. doi: 10.1002/anie.201509016. Epub 2015 Dec 22.


In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor.

Toguchi S, Hirose T, Yorita K, Fukui K, Sharpless KB, Ōmura S, Sunazuka T.

Chem Pharm Bull (Tokyo). 2016 Jul 1;64(7):695-703. doi: 10.1248/cpb.c15-00867. Epub 2015 Dec 18.


A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.

Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW.

J Am Chem Soc. 2015 Jun 17;137(23):7404-14. doi: 10.1021/jacs.5b03042. Epub 2015 Jun 8.

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