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Items: 1 to 20 of 38


A novel CXCL8 analog is effective in inhibiting the growth via cell cycle arrest and attenuating invasion of Lewis lung carcinoma.

Hsu SY, Yu HY, Lee WC, Hsiao CE, Wu CL, Cheng HT, Lin LJ, Li F, Chou YT, Cheng JW.

Onco Targets Ther. 2019 Sep 16;12:7611-7621. doi: 10.2147/OTT.S215824. eCollection 2019.


Dependence on size and shape of non-nature amino acids in the enhancement of lipopolysaccharide (LPS) neutralizing activities of antimicrobial peptides.

Chih YH, Wang SY, Yip BS, Cheng KT, Hsu SY, Wu CL, Yu HY, Cheng JW.

J Colloid Interface Sci. 2019 Jan 1;533:492-502. doi: 10.1016/j.jcis.2018.08.042. Epub 2018 Aug 14.


Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms.

Wang JJ, Williams W, Wang B, Wei J, Lu X, Cheng JW, Gordon JR, Li JM, Li F.

Int J Ophthalmol. 2018 Aug 18;11(8):1277-1283. doi: 10.18240/ijo.2018.08.05. eCollection 2018.


IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes.

Walana W, Wang JJ, Yabasin IB, Ntim M, Kampo S, Al-Azab M, Elkhider A, Dogkotenge Kuugbee E, Cheng JW, Gordon JR, Li F.

Hum Immunol. 2018 Nov;79(11):809-816. doi: 10.1016/j.humimm.2018.08.007. Epub 2018 Aug 17.


A novel CXCL8-IP10 hybrid protein is effective in blocking pulmonary pathology in a mouse model of Klebsiella pneumoniae infection.

Chen Z, Chen X, Cheng HT, Yeh SC, Yu HY, Cheng JW, Li F.

Int Immunopharmacol. 2018 Sep;62:40-45. doi: 10.1016/j.intimp.2018.06.040. Epub 2018 Jul 3.


IL-8 antagonist, CXCL8(3-72)K11R/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis.

Walana W, Ye Y, Li M, Wang J, Wang B, Cheng JW, Gordon JR, Li F.

Biomed Pharmacother. 2018 Jul;103:253-261. doi: 10.1016/j.biopha.2018.04.008. Epub 2018 Apr 24.


High Level Expression and Purification of the Clinically Active Antimicrobial Peptide P-113 in Escherichia coli.

Cheng KT, Wu CL, Yip BS, Yu HY, Cheng HT, Chih YH, Cheng JW.

Molecules. 2018 Mar 30;23(4). pii: E800. doi: 10.3390/molecules23040800.


Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1β and TNF-α production.

Wang HY, Lin L, Fu W, Yu HY, Yu N, Tan LS, Cheng JW, Pan YP.

BMC Complement Altern Med. 2017 Aug 29;17(1):426. doi: 10.1186/s12906-017-1931-9.


Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8(3-72)K11R/G31P.

Cheng HT, Yu HY, Gordon JR, Li F, Cheng JW.

Molecules. 2017 Jul 21;22(7). pii: E1229. doi: 10.3390/molecules22071229.


CXCL8 Antagonist Improves Diabetic Nephropathy in Male Mice With Diabetes and Attenuates High Glucose-Induced Mesangial Injury.

Cui S, Zhu Y, Du J, Khan MN, Wang B, Wei J, Cheng JW, Gordon JR, Mu Y, Li F.

Endocrinology. 2017 Jun 1;158(6):1671-1684. doi: 10.1210/en.2016-1781.


Role of β-naphthylalanine end-tags in the enhancement of antiendotoxin activities: Solution structure of the antimicrobial peptide S1-Nal-Nal in complex with lipopolysaccharide.

Yu HY, Chen YA, Yip BS, Wang SY, Wei HJ, Chih YH, Chen KH, Cheng JW.

Biochim Biophys Acta Biomembr. 2017 Jun;1859(6):1114-1123. doi: 10.1016/j.bbamem.2017.03.007. Epub 2017 Mar 10.


Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray.

Wang HY, Lin L, Tan LS, Yu HY, Cheng JW, Pan YP.

BMC Microbiol. 2017 Feb 17;17(1):37. doi: 10.1186/s12866-017-0948-z.


Efficacy of a novel antimicrobial peptide against periodontal pathogens in both planktonic and polymicrobial biofilm states.

Wang HY, Cheng JW, Yu HY, Lin L, Chih YH, Pan YP.

Acta Biomater. 2015 Oct;25:150-61. doi: 10.1016/j.actbio.2015.07.031. Epub 2015 Jul 22.


Selection and Characterization of DNA Aptamers Targeting All Four Serotypes of Dengue Viruses.

Chen HL, Hsiao WH, Lee HC, Wu SC, Cheng JW.

PLoS One. 2015 Jun 25;10(6):e0131240. doi: 10.1371/journal.pone.0131240. eCollection 2015.


Ultrashort Antimicrobial Peptides with Antiendotoxin Properties.

Chih YH, Lin YS, Yip BS, Wei HJ, Chu HL, Yu HY, Cheng HT, Chou YT, Cheng JW.

Antimicrob Agents Chemother. 2015 Aug;59(8):5052-6. doi: 10.1128/AAC.00519-15. Epub 2015 Jun 1.


Novel antimicrobial peptides with high anticancer activity and selectivity.

Chu HL, Yip BS, Chen KH, Yu HY, Chih YH, Cheng HT, Chou YT, Cheng JW.

PLoS One. 2015 May 13;10(5):e0126390. doi: 10.1371/journal.pone.0126390. eCollection 2015.


G31P, CXCR1/2 inhibitor, with cisplatin inhibits the growth of mice hepatocellular carcinoma and mitigates high‑dose cisplatin-induced nephrotoxicity.

Li L, Khan MN, Li Q, Chen X, Wei J, Wang B, Cheng JW, Gordon JR, Li F.

Oncol Rep. 2015 Feb;33(2):751-7. doi: 10.3892/or.2014.3659. Epub 2014 Dec 8.


ELR-CXC chemokine antagonism and cisplatin co-treatment additively reduce H22 hepatoma tumor progression and ameliorate cisplatin-induced nephrotoxicity.

Wei J, Chen X, Li Q, Chen J, Khan N, Wang B, Cheng JW, Gordon JR, Li F.

Oncol Rep. 2014 Apr;31(4):1599-604. doi: 10.3892/or.2014.2996. Epub 2014 Jan 24.


Correlations between membrane immersion depth, orientation, and salt-resistance of tryptophan-rich antimicrobial peptides.

Yu HY, Yip BS, Tu CH, Chen HL, Chu HL, Chih YH, Cheng HT, Sue SC, Cheng JW.

Biochim Biophys Acta. 2013 Nov;1828(11):2720-8. doi: 10.1016/j.bbamem.2013.07.020. Epub 2013 Jul 27.

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