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Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

J Biol Chem. 2016 Nov 18;291(47):24787-24799. Epub 2016 Oct 12.


Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.

Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1170-8. doi: 10.1016/j.bbamcr.2016.02.015. Epub 2016 Feb 24.


Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway.

Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A.

Drug Metab Dispos. 2016 Jan;44(1):137-50. doi: 10.1124/dmd.115.066308. Epub 2015 Nov 3.


Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.

Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H, Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2326-36. doi: 10.1016/j.bbamem.2015.07.003. Epub 2015 Jul 8.


Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells.

Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Nutrients. 2015 Jun 8;7(6):4578-92. doi: 10.3390/nu7064578.


Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8.

Yamazaki Y, Yasui K, Hashizume T, Suto A, Mori A, Murata Y, Yamaguchi M, Ikari A, Sugatani J.

Hepatology. 2015 Oct;62(4):1215-26. doi: 10.1002/hep.27914. Epub 2015 Jun 30.


Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCĪ²-Dependent GATA-2 in MDCK Cells.

Ikari A, Fujii N, Hahakabe S, Hayashi H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.

J Cell Physiol. 2015 Nov;230(11):2776-87. doi: 10.1002/jcp.25004.


A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation.

Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, Miwa M, Ishii S, Sugatani J, Shimizu T.

Biochem Pharmacol. 2015 Feb 15;93(4):482-95. doi: 10.1016/j.bcp.2014.12.022. Epub 2015 Jan 8.


Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.

Sugatani J, Hattori Y, Noguchi Y, Yamaguchi M, Yamazaki Y, Ikari A.

Drug Metab Dispos. 2014 Oct;42(10):1708-18. doi: 10.1124/dmd.114.059139. Epub 2014 Jul 29.


Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells.

Ikari A, Watanabe R, Sato T, Taga S, Shimobaba S, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.

Biochim Biophys Acta. 2014 Sep;1843(9):2079-88. doi: 10.1016/j.bbamcr.2014.05.017. Epub 2014 Jun 4.


Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.

Ikari A, Tonegawa C, Sanada A, Kimura T, Sakai H, Hayashi H, Hasegawa H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.

J Biol Chem. 2014 May 9;289(19):13112-23. doi: 10.1074/jbc.M113.541193. Epub 2014 Mar 21.


Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age.

Sugatani J, Sadamitsu S, Yamaguchi M, Yamazaki Y, Higa R, Hattori Y, Uchida T, Ikari A, Sugiyama W, Watanabe T, Ishii S, Miwa M, Shimizu T.

FASEB J. 2014 Jan;28(1):440-52. doi: 10.1096/fj.13-233262. Epub 2013 Oct 7.


A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.

Yamazaki Y, Yasuda K, Matsuyama T, Ishihara T, Higa R, Sawairi T, Yamaguchi M, Egi M, Akai S, Miyase T, Ikari A, Miwa M, Sugatani J.

Biochem Pharmacol. 2013 Sep 1;86(5):632-44. doi: 10.1016/j.bcp.2013.06.021. Epub 2013 Jun 28.


Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.

Ikari A, Atomi K, Yamazaki Y, Sakai H, Hayashi H, Yamaguchi M, Sugatani J.

Biochim Biophys Acta. 2013 Dec;1833(12):2617-2627. doi: 10.1016/j.bbamcr.2013.06.016. Epub 2013 Jun 29.


Function, genetic polymorphism, and transcriptional regulation of human UDP-glucuronosyltransferase (UGT) 1A1.

Sugatani J.

Drug Metab Pharmacokinet. 2013;28(2):83-92. Epub 2012 Oct 23. Review.


Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Sugatani J, Uchida T, Kurosawa M, Yamaguchi M, Yamazaki Y, Ikari A, Miwa M.

Drug Metab Dispos. 2012 Oct;40(10):2031-40. doi: 10.1124/dmd.112.046748. Epub 2012 Jul 24.


Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.

Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.

Biochim Biophys Acta. 2012 Jun;1823(6):1110-8. doi: 10.1016/j.bbamcr.2012.04.005. Epub 2012 Apr 24.


Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet.

Sugatani J, Sadamitsu S, Wada T, Yamazaki Y, Ikari A, Miwa M.

Nutr Metab (Lond). 2012 Mar 27;9(1):23. doi: 10.1186/1743-7075-9-23.


Enhancement of cell-cell contact by claudin-4 in renal epithelial Madin-Darby canine kidney cells.

Ikari A, Atomi K, Takiguchi A, Yamazaki Y, Hayashi H, Hirakawa J, Sugatani J.

J Cell Biochem. 2012 Feb;113(2):499-507. doi: 10.1002/jcb.23373.


Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells.

Ikari A, Sawada H, Sanada A, Tonegawa C, Yamazaki Y, Sugatani J.

J Cell Biochem. 2011 Dec;112(12):3563-72. doi: 10.1002/jcb.23284.


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