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Items: 1 to 20 of 78


Hierarchical Levels of Biological Systems and their Integration as a Principal Cause for Tumour Occurrence.

Nikolov S, Dimitrov A, Vera J.

Nonlinear Dynamics Psychol Life Sci. 2019 Jul;23(3):315-329.


Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.

Hannemann N, Cao S, Eriksson D, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S, Ekici A, Cañete JD, Chen X, Bäuerle T, Vera J, Bogdan C, Schett G, Bozec A.

J Clin Invest. 2019 Apr 16;130. pii: 96832. doi: 10.1172/JCI96832.


Modelling of Protein Kinase Signaling Pathways in Melanoma and Other Cancers.

Kunz M, Vera J.

Cancers (Basel). 2019 Apr 3;11(4). pii: E465. doi: 10.3390/cancers11040465. Review.


Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a.

Lee JH, Dindorf J, Eberhardt M, Lai X, Ostalecki C, Koliha N, Gross S, Blume K, Bruns H, Wild S, Schuler G, Vera J, Baur AS.

Life Sci Alliance. 2019 Mar 7;2(2). pii: e201800205. doi: 10.26508/lsa.201800205. Print 2019 Apr.


A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation.

Cantone M, Küspert M, Reiprich S, Lai X, Eberhardt M, Göttle P, Beyer F, Azim K, Küry P, Wegner M, Vera J.

Glia. 2019 May;67(5):825-843. doi: 10.1002/glia.23569. Epub 2019 Feb 7.


Exosomal lncRNAs and cancer: connecting the missing links.

Naderi-Meshkin H, Lai X, Amirkhah R, Vera J, Rasko JEJ, Schmitz U.

Bioinformatics. 2019 Jan 15;35(2):352-360. doi: 10.1093/bioinformatics/bty527.


Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.

Berger S, Goekeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M, Nouailles G.

Crit Care. 2018 Nov 1;22(1):287. doi: 10.1186/s13054-018-2224-5.


Editorial: Foundations of Theoretical Approaches in Systems Biology.

Marin-Sanguino A, Vera J, Alves R.

Front Genet. 2018 Aug 15;9:290. doi: 10.3389/fgene.2018.00290. eCollection 2018. No abstract available.


Can Gamification Contribute to Computer Modeling-Driven Biomedical Research?

Vera J, Santos G.

Front Physiol. 2018 Jul 19;9:908. doi: 10.3389/fphys.2018.00908. eCollection 2018. No abstract available.


Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis.

Marquardt S, Solanki M, Spitschak A, Vera J, Pützer BM.

Semin Cancer Biol. 2018 Dec;53:90-109. doi: 10.1016/j.semcancer.2018.06.006. Epub 2018 Jun 30. Review.


Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling.

Santos G, Lai X, Eberhardt M, Vera J.

Front Cell Infect Microbiol. 2018 May 15;8:159. doi: 10.3389/fcimb.2018.00159. eCollection 2018.


Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.

Azim K, Akkermann R, Cantone M, Vera J, Jadasz JJ, Küry P.

Front Neurosci. 2018 Apr 20;12:220. doi: 10.3389/fnins.2018.00220. eCollection 2018.


Serum levels of miR-320 family members are associated with clinical parameters and diagnosis in prostate cancer patients.

Lieb V, Weigelt K, Scheinost L, Fischer K, Greither T, Marcou M, Theil G, Klocker H, Holzhausen HJ, Lai X, Vera J, Ekici AB, Horninger W, Fornara P, Wullich B, Taubert H, Wach S.

Oncotarget. 2017 Dec 30;9(12):10402-10416. doi: 10.18632/oncotarget.23781. eCollection 2018 Feb 13.


Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.


MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance.

Lai X, Gupta SK, Schmitz U, Marquardt S, Knoll S, Spitschak A, Wolkenhauer O, Pützer BM, Vera J.

Theranostics. 2018 Jan 1;8(4):1106-1120. doi: 10.7150/thno.19904. eCollection 2018.


A web platform for the network analysis of high-throughput data in melanoma and its use to investigate mechanisms of resistance to anti-PD1 immunotherapy.

Dreyer FS, Cantone M, Eberhardt M, Jaitly T, Walter L, Wittmann J, Gupta SK, Khan FM, Wolkenhauer O, Pützer BM, Jäck HM, Heinzerling L, Vera J.

Biochim Biophys Acta Mol Basis Dis. 2018 Jun;1864(6 Pt B):2315-2328. doi: 10.1016/j.bbadis.2018.01.020. Epub 2018 Feb 23.


Community effort endorsing multiscale modelling, multiscale data science and multiscale computing for systems medicine.

Zanin M, Chorbev I, Stres B, Stalidzans E, Vera J, Tieri P, Castiglione F, Groen D, Zheng H, Baumbach J, Schmid JA, Basilio J, Klimek P, Debeljak N, Rozman D, Schmidt HHHW.

Brief Bioinform. 2019 May 21;20(3):1057-1062. doi: 10.1093/bib/bbx160.


Model-Based Phenotypic Signatures Governing the Dynamics of the Stem and Semi-differentiated Cell Populations in Dysplastic Colonic Crypts.

Nikolov S, Santos G, Wolkenhauer O, Vera J.

Bull Math Biol. 2018 Feb;80(2):360-384. doi: 10.1007/s11538-017-0378-y. Epub 2017 Dec 7.


Corrigendum: Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection.

Cantone M, Santos G, Wentker P, Lai X, Vera J.

Front Physiol. 2017 Oct 30;8:817. doi: 10.3389/fphys.2017.00817. eCollection 2017.


THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B.

Sci Rep. 2017 Sep 20;7(1):11988. doi: 10.1038/s41598-017-12154-4.

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