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Items: 1 to 20 of 31


The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy.

Owasil R, O'Neill R, Keable A, Nimmo J, MacGregor Sharp M, Kelly L, Saito S, Simpson JE, Weller RO, Smith C, Attems J, Wharton SB, Yuen HM, Carare RO.

Int J Mol Sci. 2020 Feb 12;21(4). pii: E1225. doi: 10.3390/ijms21041225.


NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.

Fadul MM, Garwood CJ, Waller R, Garrett N, Heath PR, Matthews FE, Brayne C, Wharton SB, Simpson JE.

Int J Mol Sci. 2020 Jan 4;21(1). pii: E340. doi: 10.3390/ijms21010340.


Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro.

Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC, Simpson JE.

Int J Mol Sci. 2019 Oct 22;20(20). pii: E5227. doi: 10.3390/ijms20205227.


Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations.

Coelho S, Pozo JM, Costantini M, Highley JR, Mozumder M, Simpson JE, Ince PG, Frangi AF.

Data Brief. 2019 Mar 6;23:103762. doi: 10.1016/j.dib.2019.103762. eCollection 2019 Apr.


Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier.

Goodall EF, Leach V, Wang C, Cooper-Knock J, Heath PR, Baker D, Drew DR, Saffrey MJ, Simpson JE, Romero IA, Wharton SB.

Int J Mol Sci. 2019 Jun 25;20(12). pii: E3097. doi: 10.3390/ijms20123097.


The Time Course of Recognition Memory Impairment and Glial Pathology in the hAPP-J20 Mouse Model of Alzheimer's Disease.

Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp PS, Brezzo G, Berwick J.

J Alzheimers Dis. 2019;68(2):609-624. doi: 10.3233/JAD-181238.


Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions.

Waller R, Baxter L, Fillingham DJ, Coelho S, Pozo JM, Mozumder M, Frangi AF, Ince PG, Simpson JE, Highley JR.

PLoS One. 2019 Jan 25;14(1):e0210888. doi: 10.1371/journal.pone.0210888. eCollection 2019.


TIGAR inclusion pathology is specific for Lewy body diseases.

López KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O, Highley JR.

Brain Res. 2019 Mar 1;1706:218-223. doi: 10.1016/j.brainres.2018.09.032. Epub 2018 Sep 26.


Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain.

Waller R, Murphy M, Garwood CJ, Jennings L, Heath PR, Chambers A, Matthews FE, Brayne C, Ince PG, Wharton SB, Simpson JE; Cognitive Function and Ageing Neuropathology Study Group.

Glia. 2018 Nov;66(11):2316-2323. doi: 10.1002/glia.23465. Epub 2018 Aug 10.


Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons.

Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ, Wharton SB.

Neuroscience. 2018 Oct 15;390:46-59. doi: 10.1016/j.neuroscience.2018.07.029. Epub 2018 Jul 27.


Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter.

Coelho S, Pozo JM, Costantini M, Highley JR, Mozumder M, Simpson JE, Ince PG, Frangi AF.

Neuroimage. 2018 Oct 1;179:275-287. doi: 10.1016/j.neuroimage.2018.06.040. Epub 2018 Jun 19.


Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes.

Morgan SV, Garwood CJ, Jennings L, Simpson JE, Castelli LM, Heath PR, Mihaylov SR, Vaquéz-Villaseñor I, Minshull TC, Ince PG, Dickman MJ, Hautbergue GM, Wharton SB.

Eur J Neurosci. 2018 Jun;47(12):1444-1456. doi: 10.1111/ejn.13933. Epub 2018 May 30.


Immuno-Laser-Capture Microdissection for the Isolation of Enriched Glial Populations from Frozen Post-Mortem Human Brain.

Simpson JE, Wharton SB, Heath PR.

Methods Mol Biol. 2018;1723:273-284. doi: 10.1007/978-1-4939-7558-7_16.


Spinal muscular atrophy: Factors that modulate motor neurone vulnerability.

Tu WY, Simpson JE, Highley JR, Heath PR.

Neurobiol Dis. 2017 Jun;102:11-20. doi: 10.1016/j.nbd.2017.01.011. Epub 2017 Feb 2. Review.


Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role.

Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Thomas RH, Rounding N, Sharrack B, Simpson JE.

J Neuroimmunol. 2016 Oct 15;299:139-146. doi: 10.1016/j.jneuroim.2016.09.010. Epub 2016 Sep 14.


The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.

Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE; MRC Cognitive Function Ageing Neuropathology Study Group.

Neurosci Lett. 2015 Nov 16;609:11-7. doi: 10.1016/j.neulet.2015.10.001. Epub 2015 Oct 8.


Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.

Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG, Wharton SB.

Mol Brain. 2015 Aug 22;8:51. doi: 10.1186/s13041-015-0138-6.


Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):167-79. doi: 10.1111/nan.12252. Epub 2015 Jul 7.


A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

PLoS One. 2015 Feb 23;10(2):e0118463. doi: 10.1371/journal.pone.0118463. eCollection 2015.


Age-associated white matter lesions: the MRC Cognitive Function and Ageing Study.

Wharton SB, Simpson JE, Brayne C, Ince PG.

Brain Pathol. 2015 Jan;25(1):35-43. doi: 10.1111/bpa.12219.


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