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Items: 1 to 20 of 98

1.

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

Kim TH, Tsang B, Vernon RM, Sonenberg N, Kay LE, Forman-Kay JD.

Science. 2019 Aug 23;365(6455):825-829. doi: 10.1126/science.aax4240.

PMID:
31439799
2.

Translating Material Science into Biological Function.

Vernon RM, Forman-Kay JD.

Mol Cell. 2019 Jul 11;75(1):1-2. doi: 10.1016/j.molcel.2019.06.021.

PMID:
31299205
3.

Oxidative Inhibition of Pbp1 Phase Separation.

Chong PA, Forman-Kay JD.

Biochemistry. 2019 Jul 16;58(28):3057-3059. doi: 10.1021/acs.biochem.9b00511. Epub 2019 Jul 8. No abstract available.

PMID:
31282150
4.

Proteome-wide signatures of function in highly diverged intrinsically disordered regions.

Zarin T, Strome B, Nguyen Ba AN, Alberti S, Forman-Kay JD, Moses AM.

Elife. 2019 Jul 2;8. pii: e46883. doi: 10.7554/eLife.46883.

5.

First-generation predictors of biological protein phase separation.

Vernon RM, Forman-Kay JD.

Curr Opin Struct Biol. 2019 Jun 25;58:88-96. doi: 10.1016/j.sbi.2019.05.016. [Epub ahead of print] Review.

PMID:
31252218
6.

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

Tsang B, Arsenault J, Vernon RM, Lin H, Sonenberg N, Wang LY, Bah A, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2019 Feb 14. pii: 201814385. doi: 10.1073/pnas.1814385116. [Epub ahead of print]

PMID:
30765518
7.

Phase Separation in Biology and Disease.

Forman-Kay JD, Kriwacki RW, Seydoux G.

J Mol Biol. 2018 Nov 2;430(23):4603-4606. doi: 10.1016/j.jmb.2018.09.006. Epub 2018 Sep 11. No abstract available.

PMID:
30213727
8.

RGG/RG Motif Regions in RNA Binding and Phase Separation.

Chong PA, Vernon RM, Forman-Kay JD.

J Mol Biol. 2018 Nov 2;430(23):4650-4665. doi: 10.1016/j.jmb.2018.06.014. Epub 2018 Jun 15. Review.

PMID:
29913160
9.

Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates.

Lin YH, Forman-Kay JD, Chan HS.

Biochemistry. 2018 May 1;57(17):2499-2508. doi: 10.1021/acs.biochem.8b00058. Epub 2018 Mar 13. Review.

PMID:
29509422
10.

Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase.

Csizmok V, Montecchio M, Lin H, Tyers M, Sunnerhagen M, Forman-Kay JD.

Structure. 2018 Jan 2;26(1):28-39.e2. doi: 10.1016/j.str.2017.11.003. Epub 2017 Dec 7.

11.

Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications.

Csizmok V, Forman-Kay JD.

Curr Opin Struct Biol. 2018 Feb;48:58-67. doi: 10.1016/j.sbi.2017.10.013. Epub 2017 Nov 5. Review.

PMID:
29100108
12.

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation.

Brady JP, Farber PJ, Sekhar A, Lin YH, Huang R, Bah A, Nott TJ, Chan HS, Baldwin AJ, Forman-Kay JD, Kay LE.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8194-E8203. doi: 10.1073/pnas.1706197114. Epub 2017 Sep 11.

13.

CFTR structure.

Callebaut I, Chong PA, Forman-Kay JD.

J Cyst Fibros. 2018 Mar;17(2S):S5-S8. doi: 10.1016/j.jcf.2017.08.008. Epub 2017 Aug 31. Review.

PMID:
28866450
14.

Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.

Vernon RM, Chong PA, Lin H, Yang Z, Zhou Q, Aleksandrov AA, Dawson JE, Riordan JR, Brouillette CG, Thibodeau PH, Forman-Kay JD.

J Biol Chem. 2017 Aug 25;292(34):14147-14164. doi: 10.1074/jbc.M116.772335. Epub 2017 Jun 27.

15.

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia.

Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE.

NPJ Genom Med. 2017 Apr 14;2:12. doi: 10.1038/s41525-017-0015-6.

16.

Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface.

Hudson RP, Dawson JE, Chong PA, Yang Z, Millen L, Thomas PJ, Brouillette CG, Forman-Kay JD.

Mol Pharmacol. 2017 Aug;92(2):124-135. doi: 10.1124/mol.117.108373. Epub 2017 May 25.

PMID:
28546419
17.

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors.

Scanlon DP, Bah A, Krzeminski M, Zhang W, Leduc-Pessah HL, Dong YN, Forman-Kay JD, Salter MW.

Nat Commun. 2017 May 16;8:15220. doi: 10.1038/ncomms15220.

18.

Interplay of buried histidine protonation and protein stability in prion misfolding.

Malevanets A, Chong PA, Hansen DF, Rizk P, Sun Y, Lin H, Muhandiram R, Chakrabartty A, Kay LE, Forman-Kay JD, Wodak SJ.

Sci Rep. 2017 Apr 13;7(1):882. doi: 10.1038/s41598-017-00954-7.

19.

Molecular biology: A hidden competitive advantage of disorder.

Chong PA, Forman-Kay JD.

Nature. 2017 Mar 16;543(7645):325-326. doi: 10.1038/nature21893. Epub 2017 Mar 8. No abstract available.

PMID:
28273062
20.

Synergy of cAMP and calcium signaling pathways in CFTR regulation.

Bozoky Z, Ahmadi S, Milman T, Kim TH, Du K, Di Paola M, Pasyk S, Pekhletski R, Keller JP, Bear CE, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2086-E2095. doi: 10.1073/pnas.1613546114. Epub 2017 Feb 27.

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