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Items: 1 to 20 of 29


Anti-parasitic drug discovery takes a giant leap forward.

Nickels JT Jr.

J Lipid Res. 2019 May;60(5):919-921. doi: 10.1194/jlr.C094250. Epub 2019 Mar 27. No abstract available.


New links between lipid accumulation and cancer progression.

Nickels JT Jr.

J Biol Chem. 2018 Apr 27;293(17):6635-6636. doi: 10.1074/jbc.H118.002654. Review.


Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.

Gallo-Ebert C, Francisco J, Liu HY, Draper R, Modi K, Hayward MD, Jones BK, Buiakova O, McDonough V, Nickels JT Jr.

J Biol Chem. 2018 Apr 20;293(16):5956-5974. doi: 10.1074/jbc.RA117.000800. Epub 2018 Feb 28.


A link between very long chain fatty acid elongation and mating-specific yeast cell cycle arrest.

Villasmil ML, Gallo-Ebert C, Liu HY, Francisco J, Nickels JT Jr.

Cell Cycle. 2017;16(22):2192-2203. doi: 10.1080/15384101.2017.1329065. Epub 2017 Sep 7.


Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence.

McCourt P, Liu HY, Parker JE, Gallo-Ebert C, Donigan M, Bata A, Giordano C, Kelly SL, Nickels JT Jr.

G3 (Bethesda). 2016 Nov 8;6(11):3455-3465. doi: 10.1534/g3.116.033969.


Ceramide signals for initiation of yeast mating-specific cell cycle arrest.

Villasmil ML, Francisco J, Gallo-Ebert C, Donigan M, Liu HY, Brower M, Nickels JT Jr.

Cell Cycle. 2016;15(3):441-54. doi: 10.1080/15384101.2015.1127475. Epub 2016 Jan 4.


MOGAT2: A New Therapeutic Target for Metabolic Syndrome.

Yang M, Nickels JT.

Diseases. 2015 Aug 28;3(3):176-192. doi: 10.3390/diseases3030176. Review.


Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.

Pallai R, Bhaskar A, Barnett-Bernodat N, Gallo-Ebert C, Pusey M, Nickels JT Jr, Rice LM.

Tumour Biol. 2015 Aug;36(8):6383-90. doi: 10.1007/s13277-015-3326-1. Epub 2015 Apr 2.


Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin.

Pallai R, Bhaskar A, Barnett-Bernodat N, Gallo-Ebert C, Nickels JT Jr, Rice LM.

Tumour Biol. 2015 Aug;36(8):6067-74. doi: 10.1007/s13277-015-3284-7. Epub 2015 Mar 4.


Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d.

Joseph BK, Liu HY, Francisco J, Pandya D, Donigan M, Gallo-Ebert C, Giordano C, Bata A, Nickels JT Jr.

J Biol Chem. 2015 Apr 24;290(17):10588-98. doi: 10.1074/jbc.M114.626259. Epub 2015 Feb 18.


Protein phosphatase 2A (PP2A) regulates low density lipoprotein uptake through regulating sterol response element-binding protein-2 (SREBP-2) DNA binding.

Rice LM, Donigan M, Yang M, Liu W, Pandya D, Joseph BK, Sodi V, Gearhart TL, Yip J, Bouchard M, Nickels JT Jr.

J Biol Chem. 2014 Jun 13;289(24):17268-79. doi: 10.1074/jbc.M114.570390. Epub 2014 Apr 26.


Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake.

Yang M, Liu W, Pellicane C, Sahyoun C, Joseph BK, Gallo-Ebert C, Donigan M, Pandya D, Giordano C, Bata A, Nickels JT Jr.

J Lipid Res. 2014 Feb;55(2):226-38. doi: 10.1194/jlr.M041335. Epub 2013 Dec 2.


The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression.

Gallo-Ebert C, Donigan M, Liu HY, Pascual F, Manners M, Pandya D, Swanson R, Gallagher D, Chen W, Carman GM, Nickels JT Jr.

J Biol Chem. 2013 Dec 6;288(49):35466-77. doi: 10.1074/jbc.M113.526087. Epub 2013 Oct 25.


Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor.

Gallo-Ebert C, Donigan M, Stroke IL, Swanson RN, Manners MT, Francisco J, Toner G, Gallagher D, Huang CY, Gygax SE, Webb M, Nickels JT Jr.

Antimicrob Agents Chemother. 2014;58(1):258-66. doi: 10.1128/AAC.01677-13. Epub 2013 Oct 21.


PP2A(Cdc55) regulates G1 cyclin stability.

McCourt P, Gallo-Ebert C, Gonghong Y, Jiang Y, Nickels JT Jr.

Cell Cycle. 2013 Apr 15;12(8):1201-10. doi: 10.4161/cc.24231. Epub 2013 Mar 21.


Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi.

Gallo-Ebert C, McCourt PC, Donigan M, Villasmil ML, Chen W, Pandya D, Franco J, Romano D, Chadwick SG, Gygax SE, Nickels JT Jr.

Fungal Genet Biol. 2012 Feb;49(2):101-13. doi: 10.1016/j.fgb.2011.11.006. Epub 2011 Nov 27.


Determination of the membrane topology of Arv1 and the requirement of the ER luminal region for Arv1 function in Saccharomyces cerevisiae.

Villasmil ML, Nickels JT Jr.

FEMS Yeast Res. 2011 Sep;11(6):524-7. doi: 10.1111/j.1567-1364.2011.00737.x. Epub 2011 May 31.


PP2A (Cdc)⁵⁵ is required for multiple events during meiosis I.

Nolt JK, Rice LM, Gallo-Ebert C, Bisher ME, Nickels JT.

Cell Cycle. 2011 May 1;10(9):1420-34. Epub 2011 May 1.


The putative lipid transporter, Arv1, is required for activating pheromone-induced MAP kinase signaling in Saccharomyces cerevisiae.

Villasmil ML, Ansbach A, Nickels JT Jr.

Genetics. 2011 Feb;187(2):455-65. doi: 10.1534/genetics.110.120725. Epub 2010 Nov 23.


Altering sphingolipid metabolism in Saccharomyces cerevisiae cells lacking the amphiphysin ortholog Rvs161 reinitiates sugar transporter endocytosis.

Morgan J, McCourt P, Rankin L, Swain E, Rice LM, Nickels JT Jr.

Eukaryot Cell. 2009 May;8(5):779-89. doi: 10.1128/EC.00037-09. Epub 2009 Mar 13.

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