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Items: 1 to 20 of 30


Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study.

de la Rubia JE, Drehmer E, Platero JL, Benlloch M, Caplliure-Llopis J, Villaron-Casales C, de Bernardo N, AlarcÓn J, Fuente C, Carrera S, Sancho D, GarcÍa-Pardo P, Pascual R, JuÁrez M, Cuerda-Ballester M, Forner A, Sancho-Castillo S, Barrios C, Obrador E, Marchio P, Salvador R, Holmes HE, Dellinger RW, Guarente L, Estrela JM.

Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):115-122. doi: 10.1080/21678421.2018.1536152. Epub 2019 Jan 22.


Oxidative stress and antioxidants in the pathophysiology of malignant melanoma.

Obrador E, Liu-Smith F, Dellinger RW, Salvador R, Meyskens FL, Estrela JM.

Biol Chem. 2019 Apr 24;400(5):589-612. doi: 10.1515/hsz-2018-0327. Review.


Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy.

Estrela JM, Mena S, Obrador E, Benlloch M, Castellano G, Salvador R, Dellinger RW.

J Med Chem. 2017 Dec 14;60(23):9413-9436. doi: 10.1021/acs.jmedchem.6b01026. Epub 2017 Jul 11.


Role of Natural Stilbenes in the Prevention of Cancer.

Sirerol JA, Rodríguez ML, Mena S, Asensi MA, Estrela JM, Ortega AL.

Oxid Med Cell Longev. 2016;2016:3128951. doi: 10.1155/2016/3128951. Epub 2015 Dec 21. Review.


Glutathione in metastases: From mechanisms to clinical applications.

Estrela JM, Ortega A, Mena S, Sirerol JA, Obrador E.

Crit Rev Clin Lab Sci. 2016 Aug;53(4):253-67. doi: 10.3109/10408363.2015.1136259. Epub 2016 Feb 18. Review.


Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism.

Benlloch M, Obrador E, Valles SL, Rodriguez ML, Sirerol JA, Alcácer J, Pellicer JA, Salvador R, Cerdá C, Sáez GT, Estrela JM.

Antioxid Redox Signal. 2016 Jun 10;24(17):974-90. doi: 10.1089/ars.2015.6437. Epub 2016 Mar 15.


Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis.

Sirerol JA, Feddi F, Mena S, Rodriguez ML, Sirera P, Aupí M, Pérez S, Asensi M, Ortega A, Estrela JM.

Free Radic Biol Med. 2015 Aug;85:1-11. doi: 10.1016/j.freeradbiomed.2015.03.027. Epub 2015 Apr 4.


Glucocorticoid receptor knockdown decreases the antioxidant protection of B16 melanoma cells: an endocrine system-related mechanism that compromises metastatic cell resistance to vascular endothelium-induced tumor cytotoxicity.

Obrador E, Valles SL, Benlloch M, Sirerol JA, Pellicer JA, Alcácer J, Coronado JA, Estrela JM.

PLoS One. 2014 May 6;9(5):e96466. doi: 10.1371/journal.pone.0096466. eCollection 2014.


Pterostilbene: Biomedical applications.

Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M.

Crit Rev Clin Lab Sci. 2013 May-Jun;50(3):65-78. doi: 10.3109/10408363.2013.805182. Epub 2013 Jul 1. Review.


Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6- and glutathione-dependent mechanism.

Valles SL, Benlloch M, Rodriguez ML, Mena S, Pellicer JA, Asensi M, Obrador E, Estrela JM.

J Transl Med. 2013 Mar 22;11:72. doi: 10.1186/1479-5876-11-72.


Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.

Mena S, Rodríguez ML, Ponsoda X, Estrela JM, Jäättela M, Ortega AL.

PLoS One. 2012;7(9):e44524. doi: 10.1371/journal.pone.0044524. Epub 2012 Sep 5.


Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.

Mena S, Rodriguez ML, Ortega A, Priego S, Obrador E, Asensi M, Petschen I, Cerdá M, Brown BD, Estrela JM.

J Transl Med. 2012 Jan 10;10:8. doi: 10.1186/1479-5876-10-8.


Natural polyphenols in cancer therapy.

Asensi M, Ortega A, Mena S, Feddi F, Estrela JM.

Crit Rev Clin Lab Sci. 2011 Sep-Dec;48(5-6):197-216. doi: 10.3109/10408363.2011.631268. Epub 2011 Dec 5. Review.


Intertissue flow of glutathione (GSH) as a tumor growth-promoting mechanism: interleukin 6 induces GSH release from hepatocytes in metastatic B16 melanoma-bearing mice.

Obrador E, Benlloch M, Pellicer JA, Asensi M, Estrela JM.

J Biol Chem. 2011 May 6;286(18):15716-27. doi: 10.1074/jbc.M110.196261. Epub 2011 Mar 10.


Glutathione in cancer cell death.

Ortega AL, Mena S, Estrela JM.

Cancers (Basel). 2011 Mar 11;3(1):1285-310. doi: 10.3390/cancers3011285.


Oxidative and nitrosative stress in the metastatic microenvironment.

Ortega AL, Mena S, Estrela JM.

Cancers (Basel). 2010 Mar 26;2(2):274-304. doi: 10.3390/cancers2020274.


Oxidative stress in environmental-induced carcinogenesis.

Mena S, Ortega A, Estrela JM.

Mutat Res. 2009 Mar 31;674(1-2):36-44. doi: 10.1016/j.mrgentox.2008.09.017. Epub 2008 Oct 11. Review.


Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism.

Priego S, Feddi F, Ferrer P, Mena S, Benlloch M, Ortega A, Carretero J, Obrador E, Asensi M, Estrela JM.

Mol Cancer Ther. 2008 Oct;7(10):3330-42. doi: 10.1158/1535-7163.MCT-08-0363.


Tumoricidal activity of endothelium-derived NO and the survival of metastatic cells with high GSH and Bcl-2 levels.

Ortega A, Carretero J, Obrador E, Estrela JM.

Nitric Oxide. 2008 Sep;19(2):107-14. doi: 10.1016/j.niox.2008.04.010. Epub 2008 Apr 23. Review.


Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease.

Mena S, Benlloch M, Ortega A, Carretero J, Obrador E, Asensi M, Petschen I, Brown BD, Estrela JM.

Clin Cancer Res. 2007 May 1;13(9):2658-66.

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