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Items: 1 to 20 of 26

1.

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.

Jager M, Blokzijl F, Kuijk E, Bertl J, Vougioukalaki M, Janssen R, Besselink N, Boymans S, de Ligt J, Pedersen JS, Hoeijmakers J, Pothof J, van Boxtel R, Cuppen E.

Genome Res. 2019 Jul;29(7):1067-1077. doi: 10.1101/gr.246223.118. Epub 2019 Jun 20.

2.

Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis.

Smit KN, Chang J, Derks K, Vaarwater J, Brands T, Verdijk RM, Wiemer EAC, Mensink HW, Pothof J, de Klein A, Kilic E.

Cancers (Basel). 2019 Jun 12;11(6). pii: E815. doi: 10.3390/cancers11060815.

3.

Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.

Steurer B, Janssens RC, Geverts B, Geijer ME, Wienholz F, Theil AF, Chang J, Dealy S, Pothof J, van Cappellen WA, Houtsmuller AB, Marteijn JA.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4368-E4376. doi: 10.1073/pnas.1717920115. Epub 2018 Apr 9.

4.

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ.

Cell. 2017 Mar 23;169(1):132-147.e16. doi: 10.1016/j.cell.2017.02.031.

5.

miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway.

van Jaarsveld MT, van Kuijk PF, Boersma AW, Helleman J, van IJcken WF, Mathijssen RH, Pothof J, Berns EM, Verweij J, Wiemer EA.

Mol Cancer. 2015 Nov 17;14:196. doi: 10.1186/s12943-015-0464-4.

6.

Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.

Vermeij WP, Hoeijmakers JH, Pothof J.

Annu Rev Pharmacol Toxicol. 2016;56:427-45. doi: 10.1146/annurev-pharmtox-010814-124316. Epub 2015 Oct 28. Review.

PMID:
26514200
7.

RNAome sequencing delineates the complete RNA landscape.

Derks KW, Pothof J.

Genom Data. 2015 Jul 11;5:381-4. doi: 10.1016/j.gdata.2015.07.002. eCollection 2015 Sep.

8.

Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.

Naipal KA, Raams A, Bruens ST, Brandsma I, Verkaik NS, Jaspers NG, Hoeijmakers JH, van Leenders GJ, Pothof J, Kanaar R, Boormans J, van Gent DC.

PLoS One. 2015 Apr 30;10(4):e0126029. doi: 10.1371/journal.pone.0126029. eCollection 2015.

9.

Deciphering the RNA landscape by RNAome sequencing.

Derks KW, Misovic B, van den Hout MC, Kockx CE, Gomez CP, Brouwer RW, Vrieling H, Hoeijmakers JH, van IJcken WF, Pothof J.

RNA Biol. 2015;12(1):30-42. doi: 10.1080/15476286.2015.1017202.

10.

Aging: not all DNA damage is equal.

Vermeij WP, Hoeijmakers JH, Pothof J.

Curr Opin Genet Dev. 2014 Jun;26:124-30. doi: 10.1016/j.gde.2014.06.006. Epub 2014 Sep 15. Review.

PMID:
25222498
11.

The DNA damage response: the omics era and its impact.

Derks KW, Hoeijmakers JH, Pothof J.

DNA Repair (Amst). 2014 Jul;19:214-20. doi: 10.1016/j.dnarep.2014.03.008. Epub 2014 Apr 30. Review.

12.

DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity.

van Jaarsveld MT, Wouters MD, Boersma AW, Smid M, van Ijcken WF, Mathijssen RH, Hoeijmakers JH, Martens JW, van Laere S, Wiemer EA, Pothof J.

Mol Oncol. 2014 May;8(3):458-68. doi: 10.1016/j.molonc.2013.12.011. Epub 2013 Dec 31.

13.

In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals.

Melis JP, Derks KW, Pronk TE, Wackers P, Schaap MM, Zwart E, van Ijcken WF, Jonker MJ, Breit TM, Pothof J, van Steeg H, Luijten M.

Arch Toxicol. 2014 Apr;88(4):1023-34. doi: 10.1007/s00204-013-1189-z. Epub 2014 Jan 5.

PMID:
24390151
14.

MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells.

Riepsaame J, van Oudenaren A, den Broeder BJ, van Ijcken WF, Pothof J, Leenen PJ.

Front Immunol. 2013 Oct 30;4:353. doi: 10.3389/fimmu.2013.00353. eCollection 2013.

15.

Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures.

van Spronsen M, van Battum EY, Kuijpers M, Vangoor VR, Rietman ML, Pothof J, Gumy LF, van Ijcken WF, Akhmanova A, Pasterkamp RJ, Hoogenraad CC.

PLoS One. 2013 Oct 3;8(10):e74907. doi: 10.1371/journal.pone.0074907. eCollection 2013.

16.

The kinase RSK2 modulates the sensitivity of ovarian cancer cells to cisplatin.

van Jaarsveld MT, Blijdorp IC, Boersma AW, Pothof J, Mathijssen RH, Verweij J, Wiemer EA.

Eur J Cancer. 2013 Jan;49(2):345-51. doi: 10.1016/j.ejca.2012.08.024. Epub 2012 Oct 4.

PMID:
23041051
17.

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.

Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JH, Campisi J, Vijg J, Suh Y.

BMC Genomics. 2012 Jul 31;13:353. doi: 10.1186/1471-2164-13-353.

18.

Spatiotemporal aspects of MicroRNA-mediated gene regulation.

Pothof J, van Gent DC.

Adv Exp Med Biol. 2011;722:75-85. doi: 10.1007/978-1-4614-0332-6_5. Review.

PMID:
21915783
19.

MicroRNAs, the DNA damage response and cancer.

Wouters MD, van Gent DC, Hoeijmakers JH, Pothof J.

Mutat Res. 2011 Dec 1;717(1-2):54-66. doi: 10.1016/j.mrfmmm.2011.03.012. Epub 2011 Apr 6. Review.

PMID:
21477600
20.

3rd US-EU workshop: systems level understanding of DNA damage responses.

Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L.

Mutat Res. 2010 Oct 13;692(1-2):53-60. doi: 10.1016/j.mrfmmm.2010.07.012. Epub 2010 Aug 19.

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