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Eur J Nutr. 2019 Aug 5. doi: 10.1007/s00394-019-02070-w. [Epub ahead of print]

Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study.

Collaborators (761)

Salas-Salvadó J, Martínez-González MA, Fitó M, Ros E, Tinahones FJ, Corella D, Estruch R, Vioque J, Romaguera D, Martínez JA, Wärnberg J, Lopez-Miranda J, Bueno-Cavanillas A, Alonso-Gómez ÁM, Tur JA, Serra-Majem L, Martin V, Lapetra J, Vázquez C, Pinto X, Vidal J, Daimiel L, Delgado-Rodríguez M, Rubio MA, Babio N, Sánchez-Tainta A, Schröder H, Marcos A, Warnberg J, Fernández-Aranda F, Botella C, Arós F, Aldamiz M, Alonso-Gómez A, Forga L, García-Layana A, Portu J, Timiraos J, González-Pinto A, Zorrilla I, Martínez-Kareaga M, Seoane P, Arós F, Alonso-Gómez A, Timiraos J, Aldamiz M, Portu J, Forga L, García-Layana A, Pinto AG, Zorrilla I, Martínez M, Seoane P, Stampfer MJ, Sabate J, Astrup A, Fernandez-Aviles F, Pi-Sunyer X, Fernandez-Aranda F, Lamuela R, Del Puy Portillo M, Sáez G, Gómez-Gracia E, Pedret Llaberia R, Gonzalez R, Álamo RS, Palleja FP, Balsells J, Roca JM, Gallisa TB, Vizcaino J, Alpizarte PL, Perpiñá CA, Vernet ML, Caballero C, Barco MG, Martínez MDM, Rosselló JG, Del Pozo A, Calaf CP, Zabal PA, Floresví X, Benet MC, Galindo AP, Vila JJC, Andrés FD, Soler M, Vidal MG, Vilalta J, Casajuana JB, Ricard M, Saiz F, Isach A, Martinez MSM, Font EG, Luque L, Sola CM, Bulló M, Becerra-Tomás N, Mestres G, Basora J, Mena-Sánchez G, Piñol LB, Segura MG, Papandreou C, Rosique-Esteban N, Chig S, Cano IA, García VR, Salas-Huetos A, Paz-Graniel I, Niembro LS, Hernandez-Alonso P, Canudas S, Camacho-Barcia L, García-Gavilán J, Díaz-López A, Ruiz-Canela M, Toledo E, Buil-Cosiales P, Razquin C, Bes-Rastrollo M, Tainta AS, Aranguren BS, Goñi E, Barrientos I, Canales M, Rico A, Gortari JB, Arellano AG, Diez-Espino J, Lecea-Juarez O, Cenoz-Osinaga JC, Bartolome-Resano J, Sola-Larraza A, Lozano-Oloriz E, Cano-Valles B, Eguaras S, Roquet-Jalmar EP, Galilea-Zabalza I, Lancova H, Ramallal R, Garcia-Perez ML, Estremera-Urabayen V, Ariz-Arnedo MJ, Hijos-Larraz C, Alfaro CF, Iñigo-Martinez B, Moreno RV, Martin-Almendros S, Barandiaran-Bengoetxea L, Fuertes-Goñi C, Lezaun-Indurain A, Guruchaga-Arcelus MJ, Olmedo-Cruz O, Iñigo-Martínez B, Escriche-Erviti L, Ansorena-Ros R, Sanmatin-Zabaleta R, Apalategi-Lasa J, Villanueva-Telleria J, Hernández-Espinosa MM, Arroyo-Bergera I, Herrera-Valdez L, Dorronsoro-Dorronsoro L, Vázquez Z, González JI, Sorlí JV, Portolés O, Fernández-Carrión R, Ortega-Azorín C, Barragán R, Asensio EM, Coltell O, Sáiz C, Osma R, Férriz E, González-Monje I, Giménez-Fernández F, Quiles L, Carrasco P, San Onofre N, Carratalá-Calvo A, Valero-Barceló C, Antón F, Mir C, Sánchez-Navarro S, Navas J, González-Gallego I, Bort-Llorca L, Pérez-Ollero L, Giner-Valero M, Monfort-Sáez R, Nadal-Sayol J, Pascual-Fuster V, Martínez-Pérez M, Riera C, Belda MV, Medina A, Miralles E, Ramírez-Esplugues MJ, Rojo-Furió M, Mattingley G, Delgado MA, Pages MA, Riofrío Y, Abuomar L, Blasco-Lafarga N, Tosca R, Lizán L, Valcarce AM, Medina MD, Monfort R, de Valcárcel S, Tormo N, Felipe-Román O, Lafuente S, Navío EI, Aldana G, Crespo JV, Llosa JL, González-García L, Raga-Marí R, Castañer O, Muñoz MA, Zomeño MD, Hernaéz A, Torres L, Quifer M, Llimona R, Freixer G, Pérez A, Farràs M, Elosua R, Marrugat J, Vila J, Subirana I, Pérez S, Goday A, Jordan JJC, Lerroux JAF, Boix DB, Llauradó G, Farré M, Menoyo E, Muñoz-Aguayo D, Gaixas S, Blanchart G, Sanllorente A, Soria M, Valussi J, Cuenca A, Forcano L, Pastor A, Boronat A, Tello S, Cabañero M, Franco L, De la Torre R, Medrano C, Bayó J, García MT, Robledo V, Babi P, Canals E, Soldevila N, Carrés L, Roca C, Comas MS, Gasulla G, Herraiz X, Martínez A, Vinyoles E, Verdú JM, Masague Aguade M, Baltasar Massip E, Lopez Grau M, Mengual M, Moldon V, Vila Vergaz M, Cabanes Gómez R, Ciurana, Gili Riu M, Palomeras Vidal A, Peñas F, Raya A, Sebastian MA, Valls M, de la Hera MG, González Palacios S, Torres Collado L, Valera Gran D, Compañ Gabucio L, Notario-Barandiaran L, Oncina Canovas A, Orozco Beltran D, Pertusa Martínez S, Asensio A, Zazo JM, Sellés CG, Maciá JR, Botella CS, Macián RL, V Hernándis Marsán M, Cloquell Rodrigo B, Altozano Rodado MC, Iranzo García N, Martínez Vergara MC, Candela García I, Valls Enguix R, Cases Pérez EP, López García CM, Tercero Maciá C, Morell AP, Bartolomé EA, J Ballester Baixauli J, T Cano Sánchez M, E Ayús Rojo B, Pérez EPC, Maciá CT, A Mira Castelló L, A García García I, Ballesta MJ, Polo CP, Agulló EP, Fiol M, Moñino M, Colom A, Konieczna J, Morey M, Zamanillo R, Galmés AM, Pereira V, Martín MA, Yáñez A, Llobera J, Ripoll J, Prieto R, Grases F, Costa A, Fernández-Palomeque C, Fortuny E, Noris M, Munuera S, Tomás F, Fiol F, Jover A, Janer JM, Vallespir C, Mattei I, Feuerbach N, Del Mar Sureda M, Vega S, Quintana L, Fiol A, Amador M, González S, Coll J, Moyá A, Abete I, Cantero I, Cristobo C, Ibero-Baraibar I, Zulet M, Ágreda Martínez J, Lezáun Burgui MD, Goñi Ruiz N, Bartolomé Resano R, Cano Cáceres E, Elcarte López T, Echarte Osacain E, Pérez Sanz B, Blanco Platero I, Andueza Azcárate SA, Gimeno Aznar A, Ursúa Sesma E, Ojeda Bilbao B, Martinez Jarauta J, Ugalde Sarasa L, Rípodas Echarte B, Güeto Rubio MV, Barón-López FJ, Fernández García JC, Pérez-Farinós N, Moreno-Morales N, Del C Rodríguez-Martínez M, Pérez-López J, Benavente-Marín JC, Crespo Oliva E, Contreras Fernández E, Carmona González FJ, Carabaño Moral R, Torres Moreno S, Martín Ruíz MV, Alcalá Cornide M, Fuentes Gómez V, Garcia-Rios A, Criado García J, Jiménez Morales AI, Delgado Casado N, Ortiz Morales A, Torres Peña JD, Gómez Delgado FJ, Rodríguez Cantalejo F, Caballero Villaraso J, Alcalá JF, Peña Orihuela PJ, Quintana Navarro G, Casas R, Domenech M, Viñas C, Castro-Barquero S, Ruiz-León AM, Sadurní M, Frontana G, Villanueva P, Gual M, Soriano R, Camafort M, Sierra C, Sacanella E, Sala-Vila A, Cots JM, Sarroca I, García M, Bermúdez N, Duaso I, de la Arada A, Hernández R, Simón C, de la Poza MA, Gil I, Vila M, Iglesias C, Assens N, Amatller M, Rams LL, Benet T, Fernández G, Teruel J, Azorin A, Cubells M, López D, Llovet JM, Gómez ML, Climente P, de Paula L, Soto J, Carbonell C, Llor C, Abat X, Cama A, Fortuny M, Domingo C, Liberal AI, Martínez T, Yañez E, Nieto MJ, Lloret E, Carrazoni C, Belles AM, Olmos C, Ramentol M, Capell MJ, Giner I, Muñoz A, Martín R, Moron E, Bonillo A, Sánchez G, Calbó C, Pous J, Massip M, García Y, Massagué MC, Ibañez R, Llaona J, Vidal T, Vizcay N, Segura E, Galindo C, Moreno M, Caubet M, Altirriba J, Fluxà G, Toribio P, Torrent E, Anton JJ, Viaplana A, Vieytes G, Duch N, Pereira A, Moreno MA, Sant E, Gené J, Calvillo H, Pont F, Puig M, Casasayas M, Garrich A, Senar E, Boix I, Sequeira E, Aragunde V, Riera S, Salgado M, Fuentes M, Martín E, Ubieto A, Pallarés F, Sala C, Abilla A, Moreno S, Mayor E, Colom T, Gaspar A, Gómez A, Palacios L, Garrigosa R, García Molina L, Riquelme Gallego B, Cano Ibañez N, Maldonado Calvo A, López Maldonado A, Garrido EM, Baena Dominguez A, García Jiménez F, Thomas Carazo E, Jesús Turnes González A, González Jiménez F, Padilla Ruiz F, Machado Santiago J, Martínez Bellón MD, Pueyos Sánchez A, Arribas Mir L, Rodríguez Tapioles R, Dorador Atienza F, Baena Camus L, Osorio Martos C, Rueda Lozano D, López Alcázar M, Ramos Díaz F, Cruz Rosales Sierra M, Alguacil Cubero P, López Rodriguez A, Guerrero García F, Tormo Molina J, Ruiz Rodríguez F, Rekondo J, Salaverria I, Belló MC, Loma-Osorio A, Tojal L, Bruyel P, Goicolea L, Sorto C, Casi Casanellas A, Arnal Otero ML, De Arbulo JOM, Vinagre Morgado J, Romeo Ollora J, Urraca J, Sarriegui Carrera MI, Toribio FJ, Magán E, Rodríguez A, Castro Madrid S, Gómez Merino MT, Rodríguez Jiménez M, Gutiérrez Jodra M, López Alonso B, Iturralde Iriso J, Pascual Romero C, De La Guerra AI, Abbate M, Angullo E, Argelich E, Bibiloni MM, Bouzas C, Capó X, Carreres S, Gallardo L, Gámez JM, García B, García C, Julibert A, Gómez C, Llompart I, Martorell A, Mascaró CM, Mateos D, Monserrat M, Montemayor S, Pons A, Pouso A, Ramos J, Ramos V, Ripoll T, Rodríguez T, Sanz L, Sureda A, Tejada S, Ugarriza L, Bernal López MR, Macías González M, Ruiz Nava J, Muñoz Garach A, Vilches Pérez A, González Banderas A, Alcaide Torres J, Vargas Candela A, León Fernández M, Hernández Robles R, Santamaría Fernández S, Marín JM, Valdés Hernández S, Villalobos JC, Ortiz A, Álvarez-Pérez J, Díaz Benítez EM, Díaz-Collado F, Sánchez-Villegas A, Pérez-Cabrera J, Casañas-Quintana LT, García-Guerra RB, Bautista-Castaño I, Ruano-Rodríguez C, de la Fe FS, García-Pastor JA, Macías-Gutiérrez B, Falcón-Sanabria I, Simón-García C, Santana-Santana AJ, Álvarez-Álvarez JB, Díaz-González BV, Castillo Anzalas JM, Sosa-Also RE, Medina-Ponce J, Abajo Olea S, Adlbi Sibai A, Aguado Arconada A, Álvarez L, Carriedo Ule E, Escobar Fernández M, Ferradal García JI, Fernández Vázquez JP, García González M, González Donquiles C, González Quintana C, González Rivero F, Lavinia Popescu M, López Gil JI, de la Iglesia JL, Marcos Delgado A, Merino Acevedo C, Reguero Celada S, Rodríguez Bul M, Vilorio-Marqués L, Santos-Lozano JM, Miró-Moriano L, Domínguez-Espinaco C, Vaquero-Díaz S, García-Corte FJ, Santos-Calonge A, Toro-Cortés C, Pelegrina-López N, Urbano-Fernández V, Ortega-Calvo M, Lozano-Rodríguez J, Rivera-Benítez I, Caballero-Valderrama M, Iglesias-Bonilla P, Román-Torres P, Corchado-Albalat Y, Mellado-Martín L, de Cos AI, Gutierrez S, Artola S, Galdon A, Gonzalo I, Galera A, Gimenez-Gracia M, Figueras R, Poch M, Freixedas R, Trias F, Sarasa I, Fanlo M, Lafuente H, Liceran M, Rodriguez-Sanchez A, Pallarols C, Monedero J, Corbella X, Corbella E, Altés A, Vinagre I, Mestre C, Viaplana J, Serra M, Vera J, Freitas T, Ortega E, Pla I, Ordovás JM, Micó V, Berninches L, Concejo MJ, Muñoz J, Adrián M, de la Fuente Y, Albertos C, Villahoz E, Cornejo ML, Cuesta C, Montero A, Valdés MC, Gaforio JJ, Moraleda S, Liétor N, Peis JI, Ureña T, Rueda M, Ballesta MI, Moreno Lopera C, Aragoneses Isabel C, Sirur Flores MA, de Diego MC, Bescos Cáceres T, Peña Cereceda Y, Martínez Abad M, Cabrera Vélez R, González Cerrajero M, Rubio Herrera MA, Torrego Ellacuría M, Barabash Bustelo A, Ortiz Ramos M, Garin Barrutia U, Baños R, García-Palacios A, Sáez Tormo G, Estañ-Capell N, Iradi Casal A, Monzó Beltrán L, Fandos Sánchez M, Alonso Iglesias E, Acevedo León D, Hernando Espinilla A, Mora Herranz A, Cerdá Micó C, Fernández-Crehuet Navajas J, Gutiérrez Bedmar M, García Rodriguez A, Mariscal Larrubia A, Carnero Varo M, Muñoz Bravo C, Jiménez-Murcia S, Mallorqui-Bagué N, Granero R, Agüera Z, Lozano-Madrid M.

Abstract

PURPOSE:

To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome.

METHODS:

A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively.

RESULTS:

Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82-0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82-0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84-0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82-0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence.

CONCLUSIONS:

In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.

TRIAL REGISTRATION:

ISRCTN89898870. Registration date: 24 July 2014.

KEYWORDS:

Hyperuricemia; Non-soy legumes; PREDIMED-Plus; Serum uric acid

PMID:
31385063
DOI:
10.1007/s00394-019-02070-w

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