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Mar Drugs. 2018 Apr 27;16(5). pii: E146. doi: 10.3390/md16050146.

Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis.

Author information

1
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France. eldemerdash555@gmail.com.
2
Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. eldemerdash555@gmail.com.
3
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France. Celine.Moriou@cnrs.fr.
4
LEMAR, IRD, UBO, CNRS, IFREMER, IUEM, 29280 Plouzané, France. Jordan.Toullec@univ-brest.fr.
5
CRIOBE, CNRS, EPHE, UPVD, PSL Research University, 98729 Moorea, French Polynesia. bessonmarcluc@gmail.com.
6
Observatoire Océanologique de Banyuls-sur-Mer, Université Pierre et Marie Curie Paris, 66650 Banyuls-sur-Mer, France. bessonmarcluc@gmail.com.
7
EIO, UPF, ILM, IFREMER, IRD, Faa'a, 98702 Tahiti, French Polynesia. stephanie.soulet@upf.pf.
8
EIO, UPF, ILM, IFREMER, IRD, Faa'a, 98702 Tahiti, French Polynesia. nelly.schmitt@upf.pf.
9
LEMAR, IRD, UBO, CNRS, IFREMER, IUEM, 29280 Plouzané, France. sylvain.petek@ird.fr.
10
CRIOBE, CNRS, EPHE, UPVD, PSL Research University, 98729 Moorea, French Polynesia. david.lecchini@ephe.sorbonne.fr.
11
LEMAR, IRD, UBO, CNRS, IFREMER, IUEM, 29280 Plouzané, France. cecile.debitus@ird.fr.
12
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France. Ali.ALMOURABIT@cnrs.fr.

Abstract

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 29 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.

KEYWORDS:

Suberea ianthelliformis; acetylcholinesterase inhibition; brominated tyrosine alkaloids; cytotoxicity

PMID:
29702602
PMCID:
PMC5983277
DOI:
10.3390/md16050146
[Indexed for MEDLINE]
Free PMC Article

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