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Materials (Basel). 2017 Jul 31;10(8). pii: E884. doi: 10.3390/ma10080884.

Metallic Biomaterials: Current Challenges and Opportunities.

Author information

1
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. karthika.prasad@hdr.qut.edu.au.
2
CSIRO-QUT Joint Sustainable Processes and Devices Laboratory, Commonwealth Scientific and Industrial Research Organization, P.O. Box 218, Lindfield, NSW 2070, Australia. karthika.prasad@hdr.qut.edu.au.
3
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. karthika.prasad@hdr.qut.edu.au.
4
College of Science and Engineering, Technology and Engineering, James Cook University, Townsville, QLD 4810, Australia. olga.bazaka@jcu.edu.au.
5
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. me.chua@connect.qut.edu.au.
6
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. madison.rochford@connect.qut.edu.au.
7
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. liam.fedrick@connect.qut.edu.au.
8
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. jordan.spoor@connect.qut.edu.au.
9
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. richard.symes@connect.qut.edu.au.
10
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. marcus.tieppo@connect.qut.edu.au.
11
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. ck.collins@connect.qut.edu.au.
12
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. alex.cao@connect.qut.edu.au.
13
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. david.markwell@connect.qut.edu.au.
14
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. Kostya.ostrikov@qut.edu.au.
15
CSIRO-QUT Joint Sustainable Processes and Devices Laboratory, Commonwealth Scientific and Industrial Research Organization, P.O. Box 218, Lindfield, NSW 2070, Australia. Kostya.ostrikov@qut.edu.au.
16
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. Kostya.ostrikov@qut.edu.au.
17
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. kateryna.bazaka@qut.edu.au.
18
CSIRO-QUT Joint Sustainable Processes and Devices Laboratory, Commonwealth Scientific and Industrial Research Organization, P.O. Box 218, Lindfield, NSW 2070, Australia. kateryna.bazaka@qut.edu.au.
19
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. kateryna.bazaka@qut.edu.au.
20
College of Science and Engineering, Technology and Engineering, James Cook University, Townsville, QLD 4810, Australia. kateryna.bazaka@qut.edu.au.

Abstract

Metallic biomaterials are engineered systems designed to provide internal support to biological tissues and they are being used largely in joint replacements, dental implants, orthopaedic fixations and stents. Higher biomaterial usage is associated with an increased incidence of implant-related complications due to poor implant integration, inflammation, mechanical instability, necrosis and infections, and associated prolonged patient care, pain and loss of function. In this review, we will briefly explore major representatives of metallic biomaterials along with the key existing and emerging strategies for surface and bulk modification used to improve biointegration, mechanical strength and flexibility of biometals, and discuss their compatibility with the concept of 3D printing.

KEYWORDS:

advanced materials; biomaterial; implant; inflammation; surface modification

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