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Items: 1 to 20 of 53

1.

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking.

Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Chakravarty H, Zhang S, Tam KY, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS.

Int J Biol Sci. 2018 Jun 23;14(10):1175-1185. doi: 10.7150/ijbs.26011. eCollection 2018.

2.

PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A.

Liu Y, Yang EJ, Zhang B, Miao Z, Wu C, Lyu J, Tan K, Poon TCW, Shim JS.

Cancer Lett. 2018 Nov 1;436:28-37. doi: 10.1016/j.canlet.2018.08.011. Epub 2018 Aug 14.

PMID:
30118842
3.

Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells.

Wu C, Lyu J, Yang EJ, Liu Y, Zhang B, Shim JS.

Nat Commun. 2018 Aug 10;9(1):3212. doi: 10.1038/s41467-018-05694-4.

4.

BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.

Zhang B, Lyu J, Liu Y, Wu C, Yang EJ, Pardeshi L, Tan K, Wong KH, Chen Q, Xu X, Deng CX, Shim JS.

Oncogene. 2018 Jul 24. doi: 10.1038/s41388-018-0408-8. [Epub ahead of print]

PMID:
30042414
5.

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.

Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Yang C, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS.

Cancer Lett. 2017 Nov 28;409:91-103. doi: 10.1016/j.canlet.2017.09.009. Epub 2017 Sep 18.

PMID:
28923401
6.

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim JS, Liu JO.

ACS Chem Biol. 2017 Jan 20;12(1):174-182. doi: 10.1021/acschembio.6b00849. Epub 2016 Dec 2.

7.

Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway.

Cho YS, Yen CN, Shim JS, Kang DH, Kang SW, Liu JO, Kwon HJ.

Sci Rep. 2016 Oct 3;6:34655. doi: 10.1038/srep34655.

8.

Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer.

Du B, Shim JS.

Molecules. 2016 Jul 22;21(7). pii: E965. doi: 10.3390/molecules21070965. Review.

9.

Revisiting Non-Cancer Drugs for Cancer Therapy.

Yang EJ, Wu C, Liu Y, Lv J, Sup Shim J.

Curr Top Med Chem. 2016;16(19):2144-55. Review.

PMID:
26881712
10.

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

Shim JS, Li RJ, Bumpus NN, Head SA, Kumar Pasunooti K, Yang EJ, Lv J, Shi W, Liu JO.

Clin Cancer Res. 2016 Jun 1;22(11):2709-20. doi: 10.1158/1078-0432.CCR-15-1888. Epub 2016 Jan 22.

11.

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7276-85. doi: 10.1073/pnas.1512867112. Epub 2015 Dec 10.

12.

The Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis.

Kim NH, Pham NB, Quinn RJ, Shim JS, Cho H, Cho SM, Park SW, Kim JH, Seok SH, Oh JW, Kwon HJ.

Int J Biol Sci. 2015 Jul 16;11(9):1088-99. doi: 10.7150/ijbs.10603. eCollection 2015.

13.

Existing drugs and their application in drug discovery targeting cancer stem cells.

Lv J, Shim JS.

Arch Pharm Res. 2015 Sep;38(9):1617-26. doi: 10.1007/s12272-015-0628-1. Epub 2015 Jul 9. Review.

PMID:
26152874
14.

Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism.

Shim JS, Li RJ, Lv J, Head SA, Yang EJ, Liu JO.

Cancer Lett. 2015 Jun 28;362(1):106-15. doi: 10.1016/j.canlet.2015.03.022. Epub 2015 Mar 20.

15.

Recent advances in drug repositioning for the discovery of new anticancer drugs.

Shim JS, Liu JO.

Int J Biol Sci. 2014 Jun 10;10(7):654-63. doi: 10.7150/ijbs.9224. eCollection 2014. Review.

16.

Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model.

Park H, Shim JS, Kim BS, Jung HJ, Huh TL, Kwon HJ.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):561-7. doi: 10.1016/j.bbrc.2014.06.017. Epub 2014 Jun 10.

PMID:
24928393
17.

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Wang M, Shim JS, Li RJ, Dang Y, He Q, Das M, Liu JO.

Br J Pharmacol. 2014 Oct;171(19):4478-89. doi: 10.1111/bph.12800. Epub 2014 Sep 5.

18.

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO.

J Med Chem. 2013 May 23;56(10):3996-4016. doi: 10.1021/jm400227z. Epub 2013 May 1.

19.

Tricyclic thiazoles are a new class of angiogenesis inhibitors.

Bhat S, Shim JS, Liu JO.

Bioorg Med Chem Lett. 2013 May 1;23(9):2733-7. doi: 10.1016/j.bmcl.2013.02.067. Epub 2013 Feb 24.

20.

Personalized chemotherapy profiling using cancer cell lines from selectable mice.

Kamiyama H, Rauenzahn S, Shim JS, Karikari CA, Feldmann G, Hua L, Kamiyama M, Schuler FW, Lin MT, Beaty RM, Karanam B, Liang H, Mullendore ME, Mo G, Hidalgo M, Jaffee E, Hruban RH, Jinnah HA, Roden RB, Jimeno A, Liu JO, Maitra A, Eshleman JR.

Clin Cancer Res. 2013 Mar 1;19(5):1139-46. doi: 10.1158/1078-0432.CCR-12-2127. Epub 2013 Jan 22.

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