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Items: 1 to 20 of 138


New Ophiobolin Derivatives from the Marine Fungus Aspergillus flocculosus and Their Cytotoxicities against Cancer Cells.

Choi BK, Trinh PTH, Lee HS, Choi BW, Kang JS, Ngoc NTD, Van TTT, Shin HJ.

Mar Drugs. 2019 Jun 11;17(6). pii: E346. doi: 10.3390/md17060346.


Dokdolipids A-C, Hydroxylated Rhamnolipids from the Marine-Derived Actinomycete Actinoalloteichus hymeniacidonis.

Choi BK, Lee HS, Kang JS, Shin HJ.

Mar Drugs. 2019 Apr 20;17(4). pii: E237. doi: 10.3390/md17040237.


(E)-N'-Arylidene-2-(4-oxoquinazolin-4(3H)-yl) acetohydrazides: Synthesis and evaluation of antitumor cytotoxicity and caspase activation activity.

Huan LC, Phuong CV, Truc LC, Thanh VN, Pham-The H, Huong LT, Thuan NT, Park EJ, Ji AY, Kang JS, Han SB, Tran PT, Nam NH.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):465-478. doi: 10.1080/14756366.2018.1555536.


Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis.

Yoon YJ, Han YM, Choi J, Lee YJ, Yun J, Lee SK, Lee CW, Kang JS, Chi SW, Moon JH, Lee S, Han DC, Kwon BM.

Biochem Pharmacol. 2019 May;163:46-59. doi: 10.1016/j.bcp.2019.01.017. Epub 2019 Jan 30.


Quinazolin-4(3H)-one-Based Hydroxamic Acids: Design, Synthesis and Evaluation of Histone Deacetylase Inhibitory Effects and Cytotoxicity.

Hieu DT, Anh DT, Hai PT, Thuan NT, Huong LT, Park EJ, Young Ji A, Soon Kang J, Phuong Dung PT, Han SB, Nam NH.

Chem Biodivers. 2019 Apr;16(4):e1800502. doi: 10.1002/cbdv.201800502. Epub 2019 Mar 21.


Design, Synthesis and Evaluation of Novel 3/4-((Substituted benzamidophenoxy)methyl)-N-hydroxybenzamides / propenamides as Histone Deacetylase Inhibitors and Antitumor Agents.

Anh DT, Thuan NT, Hai PT, Huong LT, Yen NTK, Han BW, Park EJ, Choi YJ, Kang JS, Hue VTM, Han SB, Nam NH.

Anticancer Agents Med Chem. 2018 Nov 13. doi: 10.2174/1871520618666181114113347. [Epub ahead of print]


Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/II╬▒ inhibitors.

Arepalli SK, Lee C, Sim S, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H.

Bioorg Med Chem. 2018 Oct 1;26(18):5181-5193. doi: 10.1016/j.bmc.2018.09.019. Epub 2018 Sep 18.


Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies.

Lee KR, Chae SH, Kim MJ, Chae YJ, Lee MY, Lee CW, Kang JS, Yoon WK, Won YS, Lee K, Moon OS, Kim YK, Kim HC.

Biomed Chromatogr. 2019 Feb;33(2):e4388. doi: 10.1002/bmc.4388. Epub 2018 Oct 30.


N'-[(E)-Arylidene]-2-(2,3-dihydro-3-oxo-4H-1,4-benzoxazin-4-yl)-acetohydrazides: Synthesis and Evaluation of Caspase Activation Activity and Cytotoxicity.

Huan LC, Truc LC, Phuong CV, Hai PT, Huong LT, Linh NTP, Thuan NT, Park EJ, Choi YJ, Kang JS, Han SB, Nam NH, Tran PT.

Chem Biodivers. 2018 Oct;15(10):e1800322. doi: 10.1002/cbdv.201800322. Epub 2018 Sep 24.


Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae.

Kwon J, Lee H, Seo YH, Yun J, Lee J, Kwon HC, Guo Y, Kang JS, Kim JJ, Lee D.

J Nat Prod. 2018 Jun 22;81(6):1444-1450. doi: 10.1021/acs.jnatprod.8b00175. Epub 2018 Jun 7.


Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.

Lee M, Kim JH, Yoon I, Lee C, Fallahi Sichani M, Kang JS, Kang J, Guo M, Lee KY, Han G, Kim S, Han JM.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5279-E5288. doi: 10.1073/pnas.1801287115. Epub 2018 May 21.


Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities.

Lee DH, Lee MY, Seo Y, Hong HJ, An HJ, Kang JS, Kim HM.

Biomaterials. 2018 Jul;171:34-45. doi: 10.1016/j.biomaterials.2018.04.029. Epub 2018 Apr 16.


Quinazoline-Based Hydroxamic Acids: Design, Synthesis, and Evaluation of Histone Deacetylase Inhibitory Effects and Cytotoxicity.

Hieu DT, Anh DT, Hai PT, Huong LT, Park EJ, Choi JE, Kang JS, Dung PTP, Han SB, Nam NH.

Chem Biodivers. 2018 Jun;15(6):e1800027. doi: 10.1002/cbdv.201800027. Epub 2018 Jun 1.


Testing Cell-Based Immunotherapy for Colorectal Cancer.

Kang JS, Yoon YD, Lee MY, Lee CW, Lee SJ, Han SB.

Methods Mol Biol. 2018;1765:299-305. doi: 10.1007/978-1-4939-7765-9_19.


Small activating RNA induced expression of VHL gene in renal cell carcinoma.

Kang MR, Park KH, Lee CW, Lee MY, Han SB, Li LC, Kang JS.

Int J Biochem Cell Biol. 2018 Apr;97:36-42. doi: 10.1016/j.biocel.2018.02.002. Epub 2018 Feb 6.


Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.

Shin HJ, Choi BK, Trinh PTH, Lee HS, Kang JS, Van TTT, Lee HS, Lee JS, Lee YJ, Lee J.

Mar Drugs. 2018 Jan 5;16(1). pii: E14. doi: 10.3390/md16010014.


Design, synthesis and evaluation of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents.

Hieu DT, Anh DT, Tuan NM, Hai PT, Huong LT, Kim J, Kang JS, Vu TK, Dung PTP, Han SB, Nam NH, Hoa ND.

Bioorg Chem. 2018 Feb;76:258-267. doi: 10.1016/j.bioorg.2017.12.007. Epub 2017 Dec 5.


Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.

Kim JH, Lee C, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang J, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM, Kim S.

Nat Commun. 2017 Sep 29;8(1):732. doi: 10.1038/s41467-017-00785-0.


Design, synthesis and biological evaluation of 1,3-diphenylbenzo[f][1,7]naphthyrdines.

Arepalli SK, Park B, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H.

Bioorg Med Chem. 2017 Oct 15;25(20):5586-5597. doi: 10.1016/j.bmc.2017.08.030. Epub 2017 Aug 22.


Blue light effect on retinal pigment epithelial cells by display devices.

Moon J, Yun J, Yoon YD, Park SI, Seo YJ, Park WS, Chu HY, Park KH, Lee MY, Lee CW, Oh SJ, Kwak YS, Jang YP, Kang JS.

Integr Biol (Camb). 2017 May 22;9(5):436-443. doi: 10.1039/c7ib00032d.


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