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Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle.

Granata C, Oliveira RSF, Little JP, Bishop DJ.

Am J Physiol Endocrinol Metab. 2019 Dec 3. doi: 10.1152/ajpendo.00233.2019. [Epub ahead of print]


Physiological basis of brief vigorous exercise to improve health.

Gibala MJ, Little JP.

J Physiol. 2019 Nov 6. doi: 10.1113/JP276849. [Epub ahead of print]


A ketone monoester drink reduces the glycemic response to an oral glucose challenge in individuals with obesity: a randomized trial.

Myette-Côté É, Caldwell HG, Ainslie PN, Clarke K, Little JP.

Am J Clin Nutr. 2019 Dec 1;110(6):1491-1501. doi: 10.1093/ajcn/nqz232.


Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study.

Rees JL, Chang CR, François ME, Marcotte-Chénard A, Fontvieille A, Klaprat ND, Dyck RA, Funk DR, Snydmiller G, Bastell K, Godkin FE, Dubé MC, Riesco E, McGavock JM, Yardley JE, Sigal RJ, Gibala MJ, Weisnagel SJ, Prado CM, Jung M, Manders R, Lee T, Singer J, Boulé NG, Little JP.

Acta Diabetol. 2019 Jul;56(7):755-765. doi: 10.1007/s00592-019-01358-x. Epub 2019 May 15.


Challenges and opportunities in exosome research-Perspectives from biology, engineering, and cancer therapy.

Li X, Corbett AL, Taatizadeh E, Tasnim N, Little JP, Garnis C, Daugaard M, Guns E, Hoorfar M, Li ITS.

APL Bioeng. 2019 Mar 27;3(1):011503. doi: 10.1063/1.5087122. eCollection 2019 Mar. Review.


Restricting carbohydrates at breakfast is sufficient to reduce 24-hour exposure to postprandial hyperglycemia and improve glycemic variability.

Chang CR, Francois ME, Little JP.

Am J Clin Nutr. 2019 May 1;109(5):1302-1309. doi: 10.1093/ajcn/nqy261.


Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes.

Neudorf H, Durrer C, Myette-Cote E, Makins C, O'Malley T, Little JP.

Mol Nutr Food Res. 2019 Jun;63(11):e1801171. doi: 10.1002/mnfr.201801171. Epub 2019 Apr 5.


Sprint exercise snacks: a novel approach to increase aerobic fitness.

Little JP, Langley J, Lee M, Myette-Côté E, Jackson G, Durrer C, Gibala MJ, Jung ME.

Eur J Appl Physiol. 2019 May;119(5):1203-1212. doi: 10.1007/s00421-019-04110-z. Epub 2019 Mar 7.


Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis.

Durrer C, Lewis N, Wan Z, Ainslie PN, Jenkins NT, Little JP.

Nutrients. 2019 Feb 26;11(3). pii: E489. doi: 10.3390/nu11030489.


A Multi-Center Comparison of O2peak Trainability Between Interval Training and Moderate Intensity Continuous Training.

Williams CJ, Gurd BJ, Bonafiglia JT, Voisin S, Li Z, Harvey N, Croci I, Taylor JL, Gajanand T, Ramos JS, Fassett RG, Little JP, Francois ME, Hearon CM Jr, Sarma S, Janssen SLJE, Van Craenenbroeck EM, Beckers P, Cornelissen VA, Pattyn N, Howden EJ, Keating SE, Bye A, Stensvold D, Wisloff U, Papadimitriou I, Yan X, Bishop DJ, Eynon N, Coombes JS.

Front Physiol. 2019 Feb 5;10:19. doi: 10.3389/fphys.2019.00019. eCollection 2019.


Do stair climbing exercise "snacks" improve cardiorespiratory fitness?

Jenkins EM, Nairn LN, Skelly LE, Little JP, Gibala MJ.

Appl Physiol Nutr Metab. 2019 Jun;44(6):681-684. doi: 10.1139/apnm-2018-0675. Epub 2019 Jan 16.


High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance.

de Matos MA, Vieira DV, Pinhal KC, Lopes JF, Dias-Peixoto MF, Pauli JR, de Castro Magalhães F, Little JP, Rocha-Vieira E, Amorim FT.

Front Physiol. 2018 Oct 31;9:1451. doi: 10.3389/fphys.2018.01451. eCollection 2018.


Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle.

Eaton M, Granata C, Barry J, Safdar A, Bishop D, Little JP.

J Sport Health Sci. 2018 Apr;7(2):191-196. doi: 10.1016/j.jshs.2017.01.003. Epub 2017 Jan 9.


The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial.

Myette-Côté É, Durrer C, Neudorf H, Bammert TD, Botezelli JD, Johnson JD, DeSouza CA, Little JP.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1210-R1219. doi: 10.1152/ajpregu.00240.2018. Epub 2018 Oct 10.


Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity.

Barry JC, Simtchouk S, Durrer C, Jung ME, Mui AL, Little JP.

Cytokine. 2018 Nov;111:460-469. doi: 10.1016/j.cyto.2018.05.035. Epub 2018 Jun 6.


Editorial: Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes.

Karstoft K, Safdar A, Little JP.

Front Endocrinol (Lausanne). 2018 May 11;9:237. doi: 10.3389/fendo.2018.00237. eCollection 2018. No abstract available.


High-Intensity Interval or Continuous Moderate Exercise: A 24-Week Pilot Trial.

Locke SR, Bourne JE, Beauchamp MR, Little JP, Barry J, Singer J, Jung ME.

Med Sci Sports Exerc. 2018 Oct;50(10):2067-2075. doi: 10.1249/MSS.0000000000001668.


The effect of brief intermittent stair climbing on glycemic control in people with type 2 diabetes: a pilot study.

Godkin FE, Jenkins EM, Little JP, Nazarali Z, Percival ME, Gibala MJ.

Appl Physiol Nutr Metab. 2018 Sep;43(9):969-972. doi: 10.1139/apnm-2018-0135. Epub 2018 May 2.


Exercise increases mitochondrial PGC-1 α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

Safdar A, Little JP, Stokl AJ, Hettinga BP, Akhtar M, Tarnopolsky MA.

J Biol Chem. 2018 Mar 30;293(13):4953. doi: 10.1074/jbc.EC118.002682. No abstract available.

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