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Items: 1 to 20 of 93


Cysteine Trisulfide Protects E. coli from Electrophile-Induced Death through the Generation of Cysteine Hydropersulfide.

Henderson CF, Bica I, Long FT, Irwin DD, Stull CH, Baker BW, Suarez Vega V, Taugher ZM, Fletes ED, Bartleson JM, Humphrey ML, Álvarez L, Akiyama M, Kumagai Y, Fukuto JM, Lin J.

Chem Res Toxicol. 2020 Feb 17;33(2):678-686. doi: 10.1021/acs.chemrestox.9b00494. Epub 2020 Jan 31.


The chemical biology of hydrogen sulfide and related hydropersulfides: interactions with biologically relevant metals and metalloproteins.

Fukuto JM, Vega VS, Works C, Lin J.

Curr Opin Chem Biol. 2020 Jan 12;55:52-58. doi: 10.1016/j.cbpa.2019.11.013. [Epub ahead of print] Review.


Manganese Porphyrin-Based SOD Mimetics Produce Polysulfides from Hydrogen Sulfide.

Olson KR, Gao Y, Arif F, Patel S, Yuan X, Mannam V, Howard S, Batinic-Haberle I, Fukuto J, Minnion M, Feelisch M, Straub KD.

Antioxidants (Basel). 2019 Dec 12;8(12). pii: E639. doi: 10.3390/antiox8120639.


Interaction of Quinone-Related Electron Acceptors with Hydropersulfide Na2S2: Evidence for One-Electron Reduction Reaction.

Abiko Y, Nakai Y, Luong NC, Bianco CL, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Apr 15;32(4):551-556. doi: 10.1021/acs.chemrestox.8b00158. Epub 2019 Feb 15.


The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.

Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Mar 18;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340. Epub 2019 Feb 7.


Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.

Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.

Redox Biol. 2019 Feb;21:101096. doi: 10.1016/j.redox.2019.101096. Epub 2019 Jan 2.


The reaction of alkyl hydropersulfides (RSSH, R = CH3 and tBu) with H2S in the gas phase and in aqueous solution.

Zhang L, Zhang X, Wu YD, Xie Y, Fukuto JM, Schaefer HF.

Phys Chem Chem Phys. 2019 Jan 2;21(2):537-545. doi: 10.1039/c8cp05503c.


Chronic exposure of the RAW246.7 macrophage cell line to H2O2 leads to increased catalase expression.

Goddu RN, Henderson CF, Young AK, Muradian BE, Calderon L, Bleeg LH, Fukuto JM, Lin J.

Free Radic Biol Med. 2018 Oct;126:67-72. doi: 10.1016/j.freeradbiomed.2018.07.021. Epub 2018 Jul 29.


Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P.

Br J Pharmacol. 2019 Feb;176(4):646-670. doi: 10.1111/bph.14394. Epub 2018 Aug 23.


A recent history of nitroxyl chemistry, pharmacology and therapeutic potential.

Fukuto JM.

Br J Pharmacol. 2019 Jan;176(2):135-146. doi: 10.1111/bph.14384. Epub 2018 Jul 1. Review.


The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems.

Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM.

Br J Pharmacol. 2019 Feb;176(4):671-683. doi: 10.1111/bph.14372. Epub 2018 Jun 28.


Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.

FEBS Lett. 2018 Jun;592(12):2140-2152. doi: 10.1002/1873-3468.13090. Epub 2018 May 24. Review.


Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species.

Garai D, Ríos-González BB, Furtmüller PG, Fukuto JM, Xian M, López-Garriga J, Obinger C, Nagy P.

Free Radic Biol Med. 2017 Dec;113:551-563. doi: 10.1016/j.freeradbiomed.2017.10.384. Epub 2017 Oct 31.


Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.

Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.


Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.

Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9.


Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling.

Álvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto JM.

Antioxid Redox Signal. 2017 Oct 1;27(10):622-633. doi: 10.1089/ars.2017.7081. Epub 2017 Jun 13. Review.


The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.

Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR, Feelisch M.

Antioxid Redox Signal. 2017 Oct 1;27(10):684-712. doi: 10.1089/ars.2017.7083. Epub 2017 Jun 6. Review.


The chemical biology of the persulfide (RSSH)/perthiyl (RSS·) redox couple and possible role in biological redox signaling.

Bianco CL, Chavez TA, Sosa V, Saund SS, Nguyen QNN, Tantillo DJ, Ichimura AS, Toscano JP, Fukuto JM.

Free Radic Biol Med. 2016 Dec;101:20-31. doi: 10.1016/j.freeradbiomed.2016.09.020. Epub 2016 Sep 25.


Selenols are resistant to irreversible modification by HNO.

Bianco CL, Moore CD, Fukuto JM, Toscano JP.

Free Radic Biol Med. 2016 Oct;99:71-78. doi: 10.1016/j.freeradbiomed.2016.07.008. Epub 2016 Jul 14.


Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

DeMartino AW, Zigler DF, Fukuto JM, Ford PC.

Chem Soc Rev. 2017 Jan 3;46(1):21-39. doi: 10.1039/c6cs00585c. Review.

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