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Items: 1 to 20 of 53


Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells.

Zhou Y, Chung PY, Ma JY, Lam AK, Law S, Chan KW, Chan AS, Li X, Lam KH, Chui CH, Tang JC.

Biology (Basel). 2019 Oct 1;8(4). pii: E75. doi: 10.3390/biology8040075.


GAEC1 drives colon cancer progression.

Lee KT, Vider J, Tang JC, Gopalan V, Lam AK.

Mol Carcinog. 2019 Jul;58(7):1145-1154. doi: 10.1002/mc.22998. Epub 2019 Mar 1.


FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features.

Islam F, Gopalan V, Law S, Tang JC, Lam AK.

Hum Pathol. 2019 May;87:1-10. doi: 10.1016/j.humpath.2018.11.033. Epub 2019 Feb 20.


Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma.

Chung PY, Lam PL, Zhou YY, Gasparello J, Finotti A, Chilin A, Marzaro G, Gambari R, Bian ZX, Kwok WM, Wong WY, Wang X, Lam AK, Chan AS, Li X, Ma JY, Chui CH, Lam KH, Tang JC.

Cells. 2018 Oct 22;7(10). pii: E177. doi: 10.3390/cells7100177.


Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma.

Chan D, Zhou Y, Chui CH, Lam KH, Law S, Chan AS, Li X, Lam AK, Tang JCO.

Cells. 2018 Sep 20;7(10). pii: E143. doi: 10.3390/cells7100143.


The design, synthesis and evaluation of selenium-containing 4-anilinoquinazoline hybrids as anticancer agents and a study of their mechanism.

An B, Zhang S, Hu J, Pan T, Huang L, Tang JC, Li X, Chan ASC.

Org Biomol Chem. 2018 Jul 7;16(25):4701-4714. doi: 10.1039/c8ob00875b. Epub 2018 Jun 14.


MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions.

Islam F, Gopalan V, Law S, Tang JC, Chan KW, Lam AK.

Hum Pathol. 2017 Apr;62:141-151. doi: 10.1016/j.humpath.2017.01.014. Epub 2017 Feb 8.


Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma.

Gopalan V, Islam F, Pillai S, Tang JC, Tong DK, Law S, Chan KW, Lam AK.

Exp Cell Res. 2016 Nov 1;348(2):146-154. doi: 10.1016/j.yexcr.2016.09.010. Epub 2016 Sep 19.


Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2.

Pun IH, Chan D, Chan SH, Chung PY, Zhou YY, Law S, Lam AK, Chui CH, Chan AS, Lam KH, Tang JC.

Cancer Res Treat. 2017 Jan;49(1):219-229. doi: 10.4143/crt.2016.190. Epub 2016 Jul 18.


Recent advances in research of natural and synthetic bioactive quinolines.

Chung PY, Bian ZX, Pun HY, Chan D, Chan AS, Chui CH, Tang JC, Lam KH.

Future Med Chem. 2015;7(7):947-67. doi: 10.4155/fmc.15.34. Review.


The puzzling issue of 'vehicle-treated control' when using ethanol as drug carrier for MCF-7 cells.

Chan RY, Lee KK, Wong WY, Tang JC, Lam KH, Cheng CH, Lau FY, Kok SH, Gambari R, Chui CH.

Phytother Res. 2014 Nov;28(11):1735-6. doi: 10.1002/ptr.5153. Epub 2014 Apr 9.


Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue.

Lam KH, Lee KK, Gambari R, Kok SH, Kok TW, Chan AS, Bian ZX, Wong WY, Wong RS, Lau FY, Tong SW, Chan KW, Cheng CH, Chui CH, Tang JC.

Phytomedicine. 2014 May 15;21(6):877-82. doi: 10.1016/j.phymed.2014.02.005. Epub 2014 Mar 26.


Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus.

Lam KH, Gambari R, Lee KK, Chen YX, Kok SH, Wong RS, Lau FY, Cheng CH, Wong WY, Bian ZX, Chan AS, Tang JC, Chui CH.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):367-70. doi: 10.1016/j.bmcl.2013.10.072. Epub 2013 Nov 8.


Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma.

Chan D, Tsoi MY, Liu CD, Chan SH, Law SY, Chan KW, Chan YP, Gopalan V, Lam AK, Tang JC.

World J Gastroenterol. 2013 May 14;19(18):2772-80. doi: 10.3748/wjg.v19.i18.2772.


In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B.

Zhao Z, Gambari R, Lee KK, Kok SH, Wong RS, Lau FY, Tang JC, Lam KH, Cheng CH, Hau DK, Chui CH, Wong WY, Wong WK.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2373-6. doi: 10.1016/j.bmcl.2013.02.049. Epub 2013 Feb 19.


Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents.

Chan SH, Chui CH, Chan SW, Kok SH, Chan D, Tsoi MY, Leung PH, Lam AK, Chan AS, Lam KH, Tang JC.

ACS Med Chem Lett. 2012 Dec 20;4(2):170-4. doi: 10.1021/ml300238z. eCollection 2013 Feb 14.


Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents.

Lam KH, Lee KK, Gambari R, Wong RS, Cheng GY, Tong SW, Chan KW, Lau FY, Lai PB, Wong WY, Chan AS, Kok SH, Tang JC, Chui CH.

Phytomedicine. 2013 Jan 15;20(2):166-71. doi: 10.1016/j.phymed.2012.09.026. Epub 2012 Nov 2.


Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureus.

Lam PL, Gambari R, Yip J, Yuen MC, Lam KH, Wong RS, Wang XW, Tang JC, Kok SH, Chui CH.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):468-71. doi: 10.1016/j.bmcl.2011.10.097. Epub 2011 Nov 12.


Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.

Wong VC, Chen H, Ko JM, Chan KW, Chan YP, Law S, Chua D, Kwong DL, Lung HL, Srivastava G, Tang JC, Tsao SW, Zabarovsky ER, Stanbridge EJ, Lung ML.

Int J Cancer. 2012 Jan 1;130(1):83-95. doi: 10.1002/ijc.25970. Epub 2011 Apr 20.


The preparation of bi-functional organophosphine oxides as potential antitumor agents.

Lam KH, Chui CH, Gambari R, Wong RS, Cheng GY, Lau FY, Lai PB, Tong SW, Chan KW, Wong WY, Chan AS, Tang JC.

Eur J Med Chem. 2010 Nov;45(11):5527-30. doi: 10.1016/j.ejmech.2010.08.038. Epub 2010 Aug 24.


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