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Items: 1 to 20 of 54

1.

Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion.

Pickering AC, Vitry P, Prystopiuk V, Garcia B, Höök M, Schoenebeck J, Geoghegan JA, Dufrêne YF, Fitzgerald JR.

PLoS Pathog. 2019 Jun 19;15(6):e1007816. doi: 10.1371/journal.ppat.1007816. eCollection 2019 Jun.

2.

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target.

Lacey KA, Mulcahy ME, Towell AM, Geoghegan JA, McLoughlin RM.

PLoS Pathog. 2019 Apr 22;15(4):e1007713. doi: 10.1371/journal.ppat.1007713. eCollection 2019 Apr.

3.

Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones.

Pietrocola G, Nobile G, Alfeo MJ, Foster TJ, Geoghegan JA, De Filippis V, Speziale P.

J Biol Chem. 2019 Mar 8;294(10):3588-3602. doi: 10.1074/jbc.RA118.005707. Epub 2019 Jan 8.

PMID:
30622139
4.

Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes.

Zapotoczna M, Riboldi GP, Moustafa AM, Dickson E, Narechania A, Morrissey JA, Planet PJ, Holden MTG, Waldron KJ, Geoghegan JA.

MBio. 2018 Oct 16;9(5). pii: e00550-18. doi: 10.1128/mBio.00550-18.

5.

Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels.

Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF.

MBio. 2018 Aug 14;9(4). pii: e01184-18. doi: 10.1128/mBio.01184-18.

6.

Mechanomicrobiology: How Mechanical Forces Activate Staphylococcus aureus Adhesion.

Geoghegan JA, Dufrêne YF.

Trends Microbiol. 2018 Aug;26(8):645-648. doi: 10.1016/j.tim.2018.05.004. Epub 2018 Jun 1.

PMID:
29866473
7.

Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion.

Herman-Bausier P, Labate C, Towell AM, Derclaye S, Geoghegan JA, Dufrêne YF.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5564-5569. doi: 10.1073/pnas.1718104115. Epub 2018 May 7.

8.

A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages.

Purves J, Thomas J, Riboldi GP, Zapotoczna M, Tarrant E, Andrew PW, Londoño A, Planet PJ, Geoghegan JA, Waldron KJ, Morrissey JA.

Environ Microbiol. 2018 Apr;20(4):1576-1589. doi: 10.1111/1462-2920.14088. Epub 2018 Mar 26.

9.

Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship.

Geoghegan JA, Irvine AD, Foster TJ.

Trends Microbiol. 2018 Jun;26(6):484-497. doi: 10.1016/j.tim.2017.11.008. Epub 2017 Dec 9. Review.

PMID:
29233606
10.

Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin.

Vitry P, Valotteau C, Feuillie C, Bernard S, Alsteens D, Geoghegan JA, Dufrêne YF.

MBio. 2017 Dec 5;8(6). pii: e01748-17. doi: 10.1128/mBio.01748-17.

11.

The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen.

Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM.

Infect Immun. 2017 Nov 17;85(12). pii: e00549-17. doi: 10.1128/IAI.00549-17. Print 2017 Dec.

12.

Live-Cell Nanoscopy in Antiadhesion Therapy.

Geoghegan JA, Foster TJ, Speziale P, Dufrêne YF.

Trends Microbiol. 2017 Jul;25(7):512-514. doi: 10.1016/j.tim.2017.04.002. Epub 2017 May 8.

PMID:
28495024
13.

Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF.

Nugent M, Wang J, Lawrence G, Zurawski T, Geoghegan JA, Dolly JO.

Bioconjug Chem. 2017 Jun 21;28(6):1684-1692. doi: 10.1021/acs.bioconjchem.7b00157. Epub 2017 May 22.

PMID:
28489355
14.

Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis.

Fleury OM, McAleer MA, Feuillie C, Formosa-Dague C, Sansevere E, Bennett DE, Towell AM, McLean WHI, Kezic S, Robinson DA, Fallon PG, Foster TJ, Dufrêne YF, Irvine AD, Geoghegan JA.

Infect Immun. 2017 May 23;85(6). pii: e00994-16. doi: 10.1128/IAI.00994-16. Print 2017 Jun.

15.

Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC.

Feuillie C, Formosa-Dague C, Hays LM, Vervaeck O, Derclaye S, Brennan MP, Foster TJ, Geoghegan JA, Dufrêne YF.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3738-3743. doi: 10.1073/pnas.1616805114. Epub 2017 Mar 20.

16.

Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody.

Ganesh VK, Liang X, Geoghegan JA, Cohen ALV, Venugopalan N, Foster TJ, Hook M.

EBioMedicine. 2016 Nov;13:328-338. doi: 10.1016/j.ebiom.2016.09.027. Epub 2016 Oct 1.

17.

Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.

Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P.

J Biol Chem. 2016 Aug 26;291(35):18148-62. doi: 10.1074/jbc.M116.731125. Epub 2016 Jul 7.

18.

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria.

Zeng Z, Surewaard BG, Wong CH, Geoghegan JA, Jenne CN, Kubes P.

Cell Host Microbe. 2016 Jul 13;20(1):99-106. doi: 10.1016/j.chom.2016.06.002. Epub 2016 Jun 23.

19.

The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens.

Lacey KA, Geoghegan JA, McLoughlin RM.

Pathogens. 2016 Feb 17;5(1). pii: E22. doi: 10.3390/pathogens5010022. Review.

20.

Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG.

Formosa-Dague C, Speziale P, Foster TJ, Geoghegan JA, Dufrêne YF.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):410-5. doi: 10.1073/pnas.1519265113. Epub 2015 Dec 29.

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