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Items: 1 to 20 of 26

1.

Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva.

Ebner JK, König GM, Kostenis E, Siegert P, Aktories K, Orth JHC.

Bone. 2019 Oct;127:592-601. doi: 10.1016/j.bone.2019.07.031. Epub 2019 Jul 31.

PMID:
31376533
2.

Involvement of Osteocytes in the Action of Pasteurella multocida Toxin.

Heni H, Ebner JK, Schmidt G, Aktories K, Orth JHC.

Toxins (Basel). 2018 Aug 13;10(8). pii: E328. doi: 10.3390/toxins10080328.

3.

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.

Brink T, Leiss V, Siegert P, Jehle D, Ebner JK, Schwan C, Shymanets A, Wiese S, Nürnberg B, Hensel M, Aktories K, Orth JHC.

PLoS Pathog. 2018 Aug 13;14(8):e1007248. doi: 10.1371/journal.ppat.1007248. eCollection 2018 Aug.

4.

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N.

Sci Rep. 2017 Aug 30;7(1):10038. doi: 10.1038/s41598-017-10607-4.

5.

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication.

Carle S, Brink T, Orth JH, Aktories K, Barth H.

Toxins (Basel). 2017 Jan 13;9(1). pii: E32. doi: 10.3390/toxins9010032.

6.

A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice.

Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH.

Cell Microbiol. 2015 Sep;17(9):1320-31. doi: 10.1111/cmi.12436. Epub 2015 Mar 30.

PMID:
25759205
7.

Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway.

Hildebrand D, Bode KA, Rieß D, Cerny D, Waldhuber A, Römmler F, Strack J, Korten S, Orth JH, Miethke T, Heeg K, Kubatzky KF.

Cell Rep. 2014 Nov 6;9(3):910-7. doi: 10.1016/j.celrep.2014.10.003. Epub 2014 Oct 30.

8.

Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin.

Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JH.

MBio. 2014 Nov 11;5(6):e02190. doi: 10.1128/mBio.02190-14.

9.

A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

Jank T, Bogdanović X, Wirth C, Haaf E, Spoerner M, Böhmer KE, Steinemann M, Orth JH, Kalbitzer HR, Warscheid B, Hunte C, Aktories K.

Nat Struct Mol Biol. 2013 Nov;20(11):1273-80. doi: 10.1038/nsmb.2688. Epub 2013 Oct 20.

PMID:
24141704
10.

Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.

Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth JH.

PLoS Pathog. 2013;9(5):e1003385. doi: 10.1371/journal.ppat.1003385. Epub 2013 May 16.

11.

Pasteurella multocida toxin as a transporter of non-cell-permeating proteins.

Bergmann S, Jehle D, Schwan C, Orth JH, Aktories K.

Infect Immun. 2013 Jul;81(7):2459-67. doi: 10.1128/IAI.00429-13. Epub 2013 Apr 29.

12.

Pasteurella multocida.(Preface).

Aktories K, Orth JH, Adler B.

Curr Top Microbiol Immunol. 2012;361:v. No abstract available.

PMID:
23230602
13.

Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins.

Orth JH, Fester I, Siegert P, Weise M, Lanner U, Kamitani S, Tachibana T, Wilson BA, Schlosser A, Horiguchi Y, Aktories K.

FASEB J. 2013 Feb;27(2):832-42. doi: 10.1096/fj.12-213900. Epub 2012 Nov 12.

14.

Molecular biology of Pasteurella multocida toxin.

Orth JH, Aktories K.

Curr Top Microbiol Immunol. 2012;361:73-92. doi: 10.1007/82_2012_201. Review.

PMID:
22371145
15.

Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butterfly Pieris rapae.

Orth JH, Schorch B, Boundy S, Ffrench-Constant R, Kubick S, Aktories K.

Toxicon. 2011 Feb;57(2):199-207. doi: 10.1016/j.toxicon.2010.11.011. Epub 2010 Nov 26.

PMID:
21112350
16.

Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways.

Preuss I, Hildebrand D, Orth JH, Aktories K, Kubatzky KF.

Cell Microbiol. 2010 Aug;12(8):1174-85. doi: 10.1111/j.1462-5822.2010.01462.x. Epub 2010 Mar 12.

PMID:
20331638
17.

Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin.

Stratmann H, Schwan C, Orth JH, Schmidt G, Aktories K.

Cell Signal. 2010 Jul;22(7):1124-31. doi: 10.1016/j.cellsig.2010.03.007. Epub 2010 Mar 6.

PMID:
20211724
18.

Pasteurella multocida toxin activates various heterotrimeric G proteins by deamidation.

Orth JH, Aktories K.

Toxins (Basel). 2010 Feb;2(2):205-14. doi: 10.3390/toxins2020205. Epub 2010 Jan 28.

19.

Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation.

Orth JH, Preuss I, Fester I, Schlosser A, Wilson BA, Aktories K.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7179-84. doi: 10.1073/pnas.0900160106. Epub 2009 Apr 15.

20.

Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins.

Preuss I, Kurig B, Nürnberg B, Orth JH, Aktories K.

Cell Signal. 2009 Apr;21(4):551-8. doi: 10.1016/j.cellsig.2008.12.007. Epub 2008 Dec 24.

PMID:
19135527

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