Format

Send to

Choose Destination
Nanomaterials (Basel). 2017 Nov 13;7(11). pii: E387. doi: 10.3390/nano7110387.

Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability.

Author information

1
School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China. Lijunbo@haust.edu.cn.
2
School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China. Lianglijuan@haust.edu.cn.
3
School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China. Liangju@haust.edu.cn.
4
School of Medicine, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China. whenas@sian.com.
5
School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China. hyzhou@haust.edu.cn.
6
School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China. gjinwu@126.com.

Abstract

A strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b-PNIPAm-@-Au NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2-methacryloyloxy propylimidazolium bromine)] (PEG-b-PMMPImB) via polyion complex of PMMA and PMMPImB. After removing the Au NPs template, asymmetric PICsomes composed of a PNIPAm inner-shell, PIC wall, and PEG outer-corona were obtained. These PICsomes have low protein absorption and thermally tunable permeability, provided by the PEG outer-corona and the PNIPAm inner-shell, respectively. Moreover, PICsome size can be tailored by using templates of predetermined sizes. This novel strategy for constructing asymmetric PICsomes with well-defined properties and controllable size is valuable for applications such as drug delivery, catalysis and monitoring of chemical reactions, and biomimetics.

KEYWORDS:

asymmetric polymersome; block copolymer; gold template; permeability; polyion complex

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center